The Home-based Older People's Exercise (HOPE) trial: A pilot randomised controlled trial of a home-based exercise intervention for older people with frailty

Age and Ageing

Volumn 43, Issue 5, 2014, Pages 687-695

  Clegg, Andrew ^a   Barber, Sally ^b   Young, John ^b   Iliffe, Steve ^c,d   Forster, Anne ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b BRADFORD INSTITUTE FOR HEALTH RESEARCH   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d UK Dementias and Neurodegenerative Diseases Research Network   (United Kingdom)

Author keywords

Exercise; Frailty; Home; Older people; Physical activity; Randomised controlled trial

Indexed keywords

AGE; AGED; AGING; CONTROLLED STUDY; DAILY LIFE ACTIVITY; DEPRESSION; ENGLAND; FEASIBILITY STUDY; FEMALE; FRAIL ELDERLY; GERIATRIC ASSESSMENT; HOME CARE; HUMAN; KINESIOTHERAPY; MALE; PILOT STUDY; PSYCHOLOGY; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; TIME FACTOR; TREATMENT OUTCOME; VERY ELDERLY; WALKING DIFFICULTY;

ACTIVITIES OF DAILY LIVING; AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; DEPRESSION; ENGLAND; EXERCISE THERAPY; FEASIBILITY STUDIES; FEMALE; FRAIL ELDERLY; GERIATRIC ASSESSMENT; HOME CARE SERVICES; HUMANS; MALE; MOBILITY LIMITATION; PILOT PROJECTS; QUALITY OF LIFE; TIME FACTORS; TREATMENT OUTCOME;

EID: 84906877875     PISSN: 00020729     EISSN: 14682834     Source Type: Journal    
DOI: 10.1093/ageing/afu033     Document Type: Article

References (31)

1. Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet 2013; 381: 752-62.
2. Fried LP, Tangen CM, Walston J et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001; 56: M146-56.
3. Song X, Mitnitski A, Rockwood K. Prevalence and 10-year outcomes of frailty in older adults in relation to deficit accumulation. J Am Geriatr Soc 2010; 58: 681-7.
4. van Praag H. Exercise and the brain: something to chew on. Trends Neurosci 2009; 32: 283-90.
5. Barber SE, Clegg AP, Young JB. Is there a role for physical activity in preventing cognitive decline in people with mild cognitive impairment? Age Ageing 2012; 41: 5-8.
6. Gleeson M, McFarlin B, Flynn M. Exercise and Toll-like receptors. Exerc Immunol Rev 2006; 12: 34-53.
7. Handschin C, Spiegelman BM. The role of exercise and PGC1alpha in inflammation and chronic disease. Nature 2008; 454: 463-9.
8. Singh MA, Ding W, Manfredi TJ et al. Insulin-like growth factor I in skeletal muscle after weight-lifting exercise in frail elders. Am J Physiol 1999; 277(1 Pt 1): E135-43.
9. Gillespie LD, Robertson MC, Gillespie WJ, Lamb SE, Gates S, Cumming RG, Rowe BH. Interventions for preventing falls in older people living in the community. Cochrane Database Syst Rev 2009: CD007146.
10. Thomas S, Mackintosh S, Halbert J. Does the 'Otago exercise programme' reduce mortality and falls in older adults?: a systematic review and meta-analysis. Age Ageing 2010; 39: 681-7.
11. Clegg A, Barber S, Young J, Forster A, Iliffe S. Do home-based exercise interventions improve outcomes for frail older people? Findings from a systematic review. Rev Clin Gerontol 2012; 22: 68-78.
12. Medical Research Council. Developing and Evaluating Complex Interventions: new Guidance. London: MRC, 2008.
13. Thabane L, Ma J, Chu R, Cheng J, Ismaila A, Rios LP, Robson R, Thabane M, Giangregorio L, Goldsmith CH. A tutorial on pilot studies: the what, why and how. BMC Med Res Methodol 2010; 10: 1.
14. Clegg A, Barber S, Young J, Forster A, Iliffe S. The Home- Based Older People's Exercise (HOPE) trial: study protocol for a randomised controlled trial. Trials 2011; 12: 143.
15. Ferrucci L, Guralnik JM, Studenski S, Fried LP, Cutler GB Jr, Walston JD. Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus report. J Am Geriatr Soc 2004; 52: 625-34.
16. Isaacs B. Clinical and laboratory studies of falls in old people. Prospects for prevention. Clin Geriatr Med 1985; 1: 513-24.
17. Podsiadlo D, Richardson S. The timed 'Up & Go': a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc 1991; 39: 142-8.
18. Savva GM, Donoghue OA, Horgan F, O'Regan C, Cronin H, Kenny RA. Using timed up-and-go to identify frail members of the older population. J Gerontol A Biol Sci Med Sci 2012; 68: 441-6.
19. Charlson M, Szatrowski TP, Peterson J, Gold J. Validation of a combined comorbidity index. J Clin Epidemiol 1994; 47: 1245-51.
20. Rolfson DB, Majumdar SR, Tsuyuki RT, Tahir A, Rockwood K. Validity and reliability of the Edmonton Frail Scale. Age Ageing 2006; 35: 526-9.
21. van Iersel MB, Munneke M, Esselink RA, Benraad CE, Olde Rikkert MG. Gait velocity and the Timed-Up-and-Go test were sensitive to changes in mobility in frail elderly patients. J Clin Epidemiol 2008; 61: 186-91.
22. Lin JH, Hsu MJ, Sheu CF et al. Psychometric comparisons of 4 measures for assessing upper-extremity function in people with stroke. Phys Ther 2009; 89: 840-50.
23. Wright AA, Hegedus EJ, David Baxter G, Abbott JH. Measurement of function in hip osteoarthritis: developing a standardized approach for physical performance measures. Physiother Theory Pract 2011; 27: 253-62.
24. Collin C, Wade DT, Davies S, Horne V. The Barthel ADL Index: a reliability study. Int Disabil Stud 1988; 10: 61-3.
25. The EuroQol Group. EuroQol-a new facility for the measurement of health-related quality of life. Health Policy 1990; 16: 199-208.
26. Sheikh JI, Yesavage JA, Brooks JO III et al. Proposed factor structure of the Geriatric Depression Scale. Int Psychogeriatr 1991; 3: 23-8.
27. Vickers AJ, Altman DG. Statistics notes: analysing controlled trials with baseline and follow up measurements. Br Med J 2001; 323: 1123-4.
28. Allison P. Missing Data. London: Sage Publications Ltd, 2002.
29. White IR, Horton NJ, Carpenter J, Pocock SJ. Strategy for intention to treat analysis in randomised trials with missing outcome data. Br Med J 2011; 342: d40.
30. Eurich DT, Johnson JA, Reid KJ, Spertus JA. Assessing responsiveness of generic and specific health related quality of life measures in heart failure. Health Qual Life Outcomes 2006; 4: 89.
31. Hocking C, Williams M, Broad J, Baskett J. Sensitivity of Shah, Vanclay and Cooper's modified Barthel Index. Clin Rehabil 1999; 13: 141-7.