Females have a blunted cardiovascular response to one year of intensive supervised endurance training

Journal of Applied Physiology

Volumn 119, Issue 1, 2015, Pages 37-46

  Howden, Erin J ^a,b   Perhonen, Merja ^a   Peshock, Ronald M ^b   Zhang, Rong ^a,b   Arbab Zadeh, Armin ^a   Adams Huet, Beverley ^b   Levine, Benjamin D ^a,b  

^a Institute for Exercise and Environmental Medicine Dallas   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Cardiac magnetic resonance imaging; Exercise training; Gender

Indexed keywords

ADULT; ANAEROBIC THRESHOLD; BLOOD VOLUME; BODY COMPOSITION; BODY SIZE; CARDIOVASCULAR FUNCTION; CROSS-SECTIONAL STUDY; CYCLING; ELECTROCARDIOGRAPHY; ENDURANCE; FEMALE; HEMATOCRIT; HUMAN; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PHYSICAL EDUCATION; PHYSIOLOGY; RUNNING; SEXUAL DEVELOPMENT; YOUNG ADULT;

ADULT; ANAEROBIC THRESHOLD; BICYCLING; BLOOD VOLUME; BODY COMPOSITION; BODY SIZE; CARDIOVASCULAR PHYSIOLOGICAL PHENOMENA; CROSS-SECTIONAL STUDIES; ELECTROCARDIOGRAPHY; FEMALE; HEMATOCRIT; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; PHYSICAL EDUCATION AND TRAINING; PHYSICAL ENDURANCE; RUNNING; SEX CHARACTERISTICS; YOUNG ADULT;

EID: 84937232476     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00092.2015     Document Type: Article

References (41)

1. Alway SE, Grumbt WH, Gonyea WJ, Stray-Gundersen J. Contrasts in muscle and myofibers of elite male and female bodybuilders. J Appl Physiol 67: 24-31, 1989.
2. American Dietetic Association, Dietitians of the American College of Sports Medicine, Rodriguez NR, Di Marco NM, Langley S. American College of Sports Medicine position stand Nutrition and athletic performance Med Sci Sports Exerc 41: 709-731, 2009.
3. Arbab-Zadeh A, Perhonen M, Howden E, Peshock RM, Zhang R, Adams-Huet B, Haykowsky MJ, Levine BD. Cardiac remodeling in response to 1 year of intensive endurance training. Circulation 130: 2152-2161, 2014.
4. Baggish AL, Wang F, Weiner RB, Elinoff JM, Tournoux F, Boland A, Picard MH, Hutter AM Jr, Wood MJ. Training-specific changes in cardiac structure and function: a prospective and longitudinal assessment of competitive athletes. J Appl Physiol 104: 1121-1128, 2008.
5. Banister EW, Morton RH, Fitz-Clarke J. Dose/response effects of exercise modeled from training: physical and biochemical measures. Ann Physiol Anthropol 11: 345-356, 1992.
6. Bannister EW, Hamilton CL. Monitoring training. In: Physiological Testing of the Elite Athlete, edited by MacDougall JD, Wenger HA. Ottawa, Canada: Canadian Association of Sport Sciences, 1982.
7. Batterham AM, George KP. Modeling the influence of body size and composition on M-mode echocardiographic dimensions. Am J Physiol Heart Circ Physiol 274: H701-H708, 1998.
8. Belenkie I, Kieser TM, Sas R, Smith ER, Tyberg JV. Evidence for left ventricular constraint during open heart surgery. Can J Cardiol 18: 951-959, 2002.
9. Brown M. Skeletal muscle and bone: effect of sex steroids and aging. Adv Physiol Ed 32: 120-126, 2008.
10. Camper-Kirby D, Welch S, Walker A, Shiraishi I, Setchell KD, Schaefer E, Kajstura J, Anversa P, Sussman MA. Myocardial Akt activation and gender: increased nuclear activity in females versus males. Circ Res 88: 1020-1027, 2001.
11. Carrick-Ranson G, Hastings JL, Bhella PS, Shibata S, Fujimoto N, Palmer D, Boyd K, Levine BD. The effect of age-related differences in body size and composition on cardiovascular determinants of VO2max. J Gerontol A Biol Sci Med Sci 68: 608-616, 2013.
12. D'Andrea A, Riegler L, Cocchia R, Scarafile R, Salerno G, Gravino R, Golia E, Vriz O, Citro R, Limongelli G, Calabro P, Di Salvo G, Caso P, Russo MG, Bossone E, Calabro R. Left atrial volume index in highly trained athletes. Am Heart J 159: 1155-1161, 2010.
13. Dorn GW, 2nd. The fuzzy logic of physiological cardiac hypertrophy. Hypertension 49: 962-970, 2007.
14. Foldager N, Blomqvist CG. Repeated plasma volume determination with the Evans Blue dye dilution technique: the method and a computer program. Comput Biol Med 21: 35-41, 1991.
15. Germain P, Roul G, Kastler B, Mossard JM, Bareiss P, Sacrez A. Inter-study variability in left ventricular mass measurement. Comparison between M-mode echography and MRI. Eur Heart J 13: 1011-1019, 1992.
16. Haines CD, Harvey PA, Leinwand LA. Estrogens mediate cardiac hypertrophy in a stimulus-dependent manner. Endocrinology 153: 4480-4490, 2012.
17. Hundley WG, Li HF, Willard JE, Landau C, Lange RA, Meshack BM, Hillis LD, Peshock RM. Magnetic resonance imaging assessment of the severity of mitral regurgitation. Comparison with invasive techniques. Circulation 92: 1151-1158, 1995.
18. Iwasaki K, Zhang R, Zuckerman JH, Levine BD. Dose-response relationship of the cardiovascular adaptation to endurance training in healthy adults: how much training for what benefit? J Appl Physiol 95: 1575-1583, 2003.
19. Jarvis SS, Levine BD, Prisk GK, Shykoff BE, Elliott AR, Rosow E, Blomqvist CG, Pawelczyk JA. Simultaneous determination of the accuracy and precision of closed-circuit cardiac output rebreathing techniques. J Appl Physiol 103: 867-874, 2007.
20. Jenkins C, Bricknell K, Chan J, Hanekom L, Marwick TH. Comparison of two- and three-dimensional echocardiography with sequential magnetic resonance imaging for evaluating left ventricular volume and ejection fraction over time in patients with healed myocardial infarction. Am J Cardiol 99: 300-306, 2007.
21. Katz J, Milliken MC, Stray-Gundersen J, Buja LM, Parkey RW, Mitchell JH, Peshock RM. Estimation of human myocardial mass with MR imaging. Radiology 169: 495-498, 1988.
22. Koenig H, Goldstone A, Lu CY. Testosterone-mediated sexual dimorphism of the rodent heart. Ventricular lysosomes, mitochondria, and cell growth are modulated by androgens. Circ Res 50: 782-787, 1982.
23. Konhilas JP, Chen H, Luczak ED, McKee LA, Regan J, Watson PA, Stauffer BL, Khalpey ZI, McKinsey TA, Horn TR, LaFleur B, Leinwand LA. Diet and sex modify exercise and cardiac adaptation in the mouse. Am J Physiol Heart Circ Physiol 308: H135-H145, 2015.
24. Konhilas JP, Maass AH, Luckey SW, Stauffer BL, Olson EN, Leinwand LA. Sex modifies exercise and cardiac adaptation in mice. Am J Physiol Heart Circ Physiol 287: H2768-H2776, 2004.
25. La Gerche A, Heidbuchel H, Burns AT, Mooney DJ, Taylor AJ, Pfluger HB, Inder WJ, Macisaac AI, Prior DL. Disproportionate exercise load and remodeling of the athlete's right ventricle. Med Sci Sports Exerc 43: 974-981, 2011.
26. Levine BD, Lane LD, Buckey JC, Friedman DB, Blomqvist CG. Left ventricular pressure-volume and Frank-Starling relations in endurance athletes. Implications for orthostatic tolerance and exercise performance. Circulation 84: 1016-1023, 1991.
27. Nagueh SF, Appleton CP, Gillebert TC, Marino PN, Oh JK, Smiseth OA, Waggoner AD, Flachskampf FA, Pellikka PA, Evangelista A. Recommendations for the evaluation of left ventricular diastolic function by echocardiography. J Am Soc Echocardiogr 22: 107-133, 2009.
28. Nikolic S, Yellin EL, Tamura K, Vetter H, Tamura T, Meisner JS, Frater RW. Passive properties of canine left ventricle: diastolic stiffness and restoring forces. Circ Res 62: 1210-1222, 1988.
29. Pelliccia A, Maron BJ, Culasso F, Spataro A, Caselli G. Athlete's heart in women. Echocardiographic characterization of highly trained elite female athletes. J Am Med Assoc 276: 211-215, 1996.
30. Perhonen MA, Franco F, Lane LD, Buckey JC, Blomqvist CG, Zerwekh JE, Peshock RM, Weatherall PT, Levine BD. Cardiac atrophy after bed rest and spaceflight. J Appl Physiol 91: 645-653, 2001.
31. Peshock RM, Willett DL, Sayad DE, Hundley WG, Chwialkowski MC, Clarke GD, Parkey RW. Quantitative MR imaging of the heart. Magn Reson Imaging Clin N Am 4: 287-305, 1996.
32. Petersen SE, Hudsmith LE, Robson MD, Doll HA, Francis JM, Wiesmann F, Jung BA, Hennig J, Watkins H, Neubauer S. Sexspecific characteristics of cardiac function, geometry, and mass in young adult elite athletes. J Magn Res Imaging 24: 297-303, 2006.
33. Scharhag J, Schneider G, Urhausen A, Rochette V, Kramann B, Kindermann W. Athlete's heart: right and left ventricular mass and function in male endurance athletes and untrained individuals determined by magnetic resonance imaging. J Am Coll Cardiol 40: 1856-1863, 2002.
34. Sun B, Ma JZ, Yong YH, Lv YY. The upper limit of physiological cardiac hypertrophy in elite male and female athletes in China. Eur J Appl Physiol 101: 457-463, 2007.
35. Tipton KD, Witard OC. Protein requirements and recommendations for athletes: relevance of ivory tower arguments for practical recommendations. Clin Sports Med 26: 17-36, 2007.
36. Utomi V, Oxborough D, Whyte GP, Somauroo J, Sharma S, Shave R, Atkinson G, George K. Systematic review and meta-analysis of training mode, imaging modality and body size influences on the morphology and function of the male athlete's heart. Heart 99: 1727-1733, 2013.
37. Vigil J. Road To The Top. Albuquerque, NM: Creative Designs, 1995.
38. Vingren JL, Kraemer WJ, Ratamess NA, Anderson JM, Volek JS, Maresh CM. Testosterone physiology in resistance exercise and training: the up-stream regulatory elements. Sports Med 40: 1037-1053, 2010.
39. Vuille C, Weyman A. General considerations, assessment of chamber size and function. In: Principles and Practices of Echocardiography, edited by Weyman AE. Philadelphia, PA: Lea and Febiger, 1994, p. 575-624.
40. Whyte GP, George K, Sharma S, Firoozi S, Stephens N, Senior R, McKenna WJ. The upper limit of physiological cardiac hypertrophy in elite male and female athletes: the British experience. Eur J Appl Physiol 92: 592-597, 2004.
41. Wilmore JH, Behnke AR. An anthropometric estimation of body density and lean body weight in young men. J Appl Physiol 27: 25-31, 1969.