The effect of age-related differences in body size and composition on cardiovascular determinants of VO2max

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 68, Issue 5, 2013, Pages 608-616

  Carrick Ranson, Graeme ^a,b   Hastings, Jeffrey L ^a,b,c   Bhella, Paul S ^b   Shibata, Shigeki ^a,b   Fujimoto, Naoki ^a,b   Palmer, Dean ^b   Boyd, Kara ^b   Levine, Benjamin D ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b PRESBYTERIAN HOSPITAL OF DALLAS   (United States)

^c VA NORTH TEXAS HEALTH CARE SYSTEM   (United States)

Author keywords

Aging; Body composition.; Maximal exercise capacity; Stroke volume; Total blood volume

Indexed keywords

TULIP BREAKING VIRUS;

ADULT; AGE; AGED; ARTICLE; BODY COMPOSITION; BODY SIZE; CARDIOVASCULAR FUNCTION; FEMALE; HUMAN; MALE; MIDDLE AGED; OXYGEN CONSUMPTION; PHYSIOLOGY; RETROSPECTIVE STUDY; VERY ELDERLY;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; BODY COMPOSITION; BODY SIZE; CARDIOVASCULAR PHYSIOLOGICAL PHENOMENA; FEMALE; HUMANS; MALE; MIDDLE AGED; OXYGEN CONSUMPTION; RETROSPECTIVE STUDIES; YOUNG ADULT;

MLCS; MLOWN;

EID: 84876254797     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/gls220     Document Type: Article

References (48)

1. Fleg JL, Lakatta EG. Role of muscle loss in the age-associated reduc-tion in VO2 max. J Appl Physiol. 1988;65:1147-1151.
2. Fleg JL, Morrell CH, Bos AG, et al. Accelerated longitudinal decline of aerobic capacity in healthy older adults. Circulation. 2005;112: 674-682.
3. rd, et al. Effects of aging, sex, and physical training on cardiovascular responses to exercise. Circulation. 1992;86:494-503.
4. Rogers MA, Hagberg JM, Martin WH 3rd, Ehsani AA, Holloszy JO. Decline in VO2max with aging in master athletes and sedentary men. J Appl Physiol. 1990;68:2195-2199.
5. Tanaka H, Desouza CA, Jones PP, Stevenson ET, Davy KP, Seals DR. Greater rate of decline in maximal aerobic capacity with age in physically active vs. sedentary healthy women. J Appl Physiol. 1997;83:1947-1953.
6. Toth MJ, Gardner AW, Ades PA, Poehlman ET. Contribution of body composition and physical activity to age-related decline in peak VO2 in men and women. J Appl Physiol. 1994;77:647-652.
7. Fleg JL, O'Connor F, Gerstenblith G, et al. Impact of age on the car-diovascular response to dynamic upright exercise in healthy men and women. J Appl Physiol. 1995;78:890-900.
8. Tanaka H, Monahan KD, Seals DR. Age-predicted maximal heart rate revisited. J Am Coll Cardiol. 2001;37:153-156.
9. Hossack KF, Bruce RA. Maximal cardiac function in sedentary nor-mal men and women: comparison of age-related changes. J Appl Physiol. 1982;53:799-804.
10. Becklake MR, Frank H, Dagenais GR, Ostiguy GL, Guzman CA. Infuence of age and sex on exercise cardiac output. J Appl Physiol. 1965;20:938-947.
11. Rodeheffer RJ, Gerstenblith G, Becker LC, Fleg JL, Weisfeldt ML, Lakatta EG. Exercise cardiac output is maintained with advancing age in healthy human subjects: cardiac dilatation and increased stroke volume compensate for a diminished heart rate. Circulation. 1984;69:203-213.
12. Julius S, Amery A, Whitlock LS, Conway J. Infuence of age on the hemodynamic response to exercise. Circulation. 1967;36:222-230.
13. Hagberg JM, Goldberg AP, Lakatta L, et al. Expanded blood volumes contribute to the increased cardiovascular performance of endurance-trained older men. J Appl Physiol. 1998;85:484-489.
14. Hopper MK, Coggan AR, Coyle EF. Exercise stroke volume relative to plasma-volume expansion. J Appl Physiol. 1988;64:404-408.
15. Davy KP, Seals DR. Total blood volume in healthy young and older men. J Appl Physiol. 1994;76:2059-2062.
16. Jones PP, Davy KP, DeSouza CA, van Pelt RE, Seals DR. Absence of age-related decline in total blood volume in physically active females. Am J Physiol. 1997;272(6 Pt 2):H2534-H2540.
17. Ito T, Takamata A, Yaegashi K, et al. Role of blood volume in the age-associated decline in peak oxygen uptake in humans. Jpn J Physiol. 2001;51:607-612.
18. Hunt BE, Davy KP, Jones PP, et al. Role of central circulatory factors in the fat-free mass-maximal aerobic capacity relation across age. Am J Physiol. 1998;275(4 Pt 2):H1178-H1182.
19. de Simone G, Devereux RB, Daniels SR, et al. Stroke volume and cardiac output in normotensive children and adults. Assessment of relations with body size and impact of overweight. Circulation. 1997;95:1837-1843.
20. Feldschuh J, Enson Y. Prediction of the normal blood volume. Relation of blood volume to body habitus. Circulation. 1977;56(4 Pt 1):605-612.
21. Convertino VA, Ludwig DA. Validity of VO(2 max) in predicting blood volume: implications for the effect of ftness on aging. Am J Physiol Regul Integr Comp Physiol. 2000;279:R1068-R1075.
22. Rowell LB. Human Cardiovascular Control. New York: Oxford University Press; 1993.
23. Arbab-Zadeh A, Dijk E, Prasad A, et al. Effect of aging and physical activ-ity on left ventricular compliance. Circulation. 2004;110:1799-1805.
24. Jarvis SS, Levine BD, Prisk GK, et al. Simultaneous determination of the accuracy and precision of closed-circuit cardiac output rebreathing techniques. J Appl Physiol. 2007;103:867-874.
25. Gore CJ, Hopkins WG, Burge CM. Errors of measurement for blood volume parameters: a meta-analysis. J Appl Physiol. 2005;99:1745-1758.
26. Burge CM, Skinner SL. Determination of hemoglobin mass and blood volume with CO: evaluation and application of a method. J Appl Physiol. 1995;79:623-631.
27. Gore CJ, Rodríguez FA, Truijens MJ, Townsend NE, Stray-Gundersen J, Levine BD. Increased serum erythropoietin but not red cell produc-tion after 4 wk of intermittent hypobaric hypoxia (4,000-5,500 m). J Appl Physiol. 2006;101:1386-1393.
28. Hermansen L, Ekblom B, Saltin B. Cardiac output during submaxi-mal and maximal treadmill and bicycle exercise. J Appl Physiol. 1970;29:82-86.
29. Beavers KM, Miller ME, Rejeski WJ, Nicklas BJ, Krichevsky SB. Fat mass loss predicts gain in physical function with intentional weight loss in older adults. J Gerontol A Biol Sci Med Sci. 2012.
30. Ferrara CM, Goldberg AP, Ortmeyer HK, Ryan AS. Effects of aero-bic and resistive exercise training on glucose disposal and skeletal muscle metabolism in older men. J Gerontol A Biol Sci Med Sci. 2006;61:480-487.
31. Hawkins S, Wiswell R. Rate and mechanism of maximal oxygen con-sumption decline with aging: implications for exercise training. Sports Med. 2003;33:877-888.
32. McGuire DK, Levine BD, Williamson JW, et al. A 30-year fol-low-up of the Dallas Bedrest and Training Study: II. Effect of age on cardiovascular adaptation to exercise training. Circulation. 2001;104:1358-1366.
33. Higginbotham MB, Morris KG, Williams RS, Coleman RE, Cobb FR. Physiologic basis for the age-related decline in aerobic work capacity Am J Cardiol. 1986;57:1374-1379.
34. Higginbotham MB, Morris KG, Williams RS, McHale PA, Coleman RE, Cobb FR. Regulation of stroke volume during sub-maximal and maximal upright exercise in normal man. Circ Res. 1986;58:281-291.
35. Chantler PD, Clements RE, Sharp L, George KP, Tan LB, Goldspink DF. The infuence of body size on measurements of overall cardiac function. Am J Physiol heart Circ Physiol. 2005;289:H2059-H2065.
36. Chien S, Usami S, Simmons RL, McAllister FF, Gregersen MI. Blood volume and age: repeated measurements on normal men after 17 years. J Appl Physiol. 1966;21:583-588.
37. Yiengst MJ, Shock NW. Blood and plasma volume in adult males. J Appl Physiol. 1962;17:195-198.
38. Hagen JL, Krause DJ, Baker DJ, Fu MH, Tarnopolsky MA, Hepple RT. Skeletal muscle aging in F344BN F1-hybrid rats: I. Mitochondrial dysfunction contributes to the age-associated reduction in VO2max. J Gerontol A Biol Sci Med Sci. 2004;59:1099-1110.
39. Beere PA, Russell SD, Morey MC, Kitzman DW, Higginbotham MB. Aerobic exercise training can reverse age-related peripheral circula-tory changes in healthy older men. Circulation. 1999;100:1085-1094.
40. Poole JG, Lawrenson L, Kim J, Brown C, Richardson RS. Vascular and metabolic response to cycle exercise in sedentary humans: effect of age. Am J Physiol heart Circ Physiol. 2003;284:H1251-H1259.
41. Proctor DN, Shen PH, Dietz NM, et al. Reduced leg blood fow dur-ing dynamic exercise in older endurance-trained men. J Appl Physiol. 1998;85:68-75.
42. Coggan AR, Spina RJ, King DS, et al . Histochemical and enzymatic comparison of the gastrocnemius muscle of young and elderly men and women. J Gerontol. 1992;47:B71-B76.
43. Coggan AR, Spina RJ, King DS, et al . Skeletal muscle adaptations to endurance training in 60- to 70-yr-old men and women. J Appl Physiol. 1992;72:1780-1786.
44. Batterham AM, George KP, Whyte G, Sharma S, McKenna W. Scaling cardiac structural data by body dimensions: a review of theory, prac-tice, and problems. Int J Sports Med. 1999;20:495-502.
45. Chantler PD, Lakatta EG. Role of body size on cardiovascular function: can we see the meat through the fat? hypertension. 2009;54:459-461.
46. Chirinos JA, Rietzschel ER, De Buyzere ML, et al.; Asklepios investigators. Arterial load and ventricular-arterial coupling: physi-ologic relations with body size and effect of obesity. hypertension. 2009;54:558-566.
47. Heinonen I, Bucci M, Kemppainen J, Knuuti J, Nuutila P, Boushel RC, Kalliokoski KK. The regulation of subcutaneous adipose tissue blood fow during exercise in humans. J Appl Physiol. 2012;112:1059-1063.
48. Saltin B. Hemodynamic adaptations to exercise. Am J Cardiol. 1985;55:42D-47D.