Sugar-decorated mesoporous silica nanoparticles as delivery vehicles for the poorly soluble drug celastrol enables targeted induction of apoptosis in cancer cells

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 96, Issue , 2015, Pages 11-21

  Niemelä, Erik ^a   Desai, Diti ^a   Nkizinkiko, Yves ^a   Eriksson, John E ^a   Rosenholm, Jessica M ^a  

^a ÅBO AKADEMI UNIVERSITY   (Finland)

Author keywords

Cancer therapy; Celastrol; Glucose consumption; Mesoporous silica nanoparticles; Surface functionalization; Targeted drug delivery

Indexed keywords

CELASTROL; GLUCOSE; POLYETHYLENEIMINE; SILICA NANOPARTICLE; SUGAR; ANTINEOPLASTIC AGENT; DRUG CARRIER; IMINE; NANOPARTICLE; POLY(ETHYLENE IMINE); POLYETHYLENE DERIVATIVE; SILICON DIOXIDE; TRIPTERINE; TRITERPENE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; DRUG SPECIFICITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; SPECTROPHOTOMETRY; SURFACE CHARGE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; DRUG FORMULATION; DRUG RELEASE; ENDOCYTOSIS; HELA CELL LINE; PARTICLE SIZE; POROSITY; SOLUBILITY; SURFACE PROPERTY; TRANSMISSION ELECTRON MICROSCOPY;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL SURVIVAL; DRUG CARRIERS; DRUG COMPOUNDING; DRUG LIBERATION; ENDOCYTOSIS; FLOW CYTOMETRY; GLUCOSE; HELA CELLS; HUMANS; IMINES; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; PARTICLE SIZE; POLYETHYLENES; POROSITY; SILICON DIOXIDE; SOLUBILITY; SURFACE PROPERTIES; TRITERPENES;

EID: 84937231871     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2015.07.009     Document Type: Article

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