LC-MS/MS method for the determination of two metabolites of tribendimidine, deacylated amidantel and its acetylated metabolite in plasma, blood and dried blood spots

Journal of Pharmaceutical and Biomedical Analysis

Volumn 105, Issue 1, 2015, Pages 163-173

  Duthaler, Urs ^a,b   Keiser, Jennifer ^a,b   Huwyler, Jörg ^b  

^a SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Anthelmintic drug; Deacylated amidantel; Opisthorchis viverrini; Pharmacokinetics; Tribendimidine

Indexed keywords

2 PROPANOL; ACETONITRILE; AMIDANTEL; AMMONIUM ACETATE; ANTITREMATODAL AGENT; FORMIC ACID; TRIBENDIMIDINE; UNCLASSIFIED DRUG; ANTINEMATODAL AGENT; PHENYLENEDIAMINE DERIVATIVE;

ACCURACY; ARTICLE; BLOOD; DRIED BLOOD SPOT TESTING; DRUG DETERMINATION; DRUG METABOLISM; ELECTROSPRAY MASS SPECTROMETRY; ELUTION; HEMATOCRIT; HEMOLYSIS; HUMAN; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MAXIMUM PLASMA CONCENTRATION; METABOLITE; PLASMA; PRIORITY JOURNAL; SIGNAL NOISE RATIO; SINGLE DRUG DOSE; SOLID PHASE EXTRACTION; SOLVENT EXTRACTION; TANDEM MASS SPECTROMETRY; ACETYLATION; BLOOD STAIN; CALIBRATION; CHEMICAL STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIMIT OF DETECTION; METABOLISM; PROCEDURES; REPRODUCIBILITY; STANDARD;

ACETYLATION; ANTINEMATODAL AGENTS; BLOOD STAINS; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; LIMIT OF DETECTION; MOLECULAR STRUCTURE; PHENYLENEDIAMINES; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 84937204001     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2014.12.006     Document Type: Article

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