Biphenotypic human papillomavirus-associated head and neck squamous cell carcinoma: A report of two cases

Diagnostic Pathology

Volumn 10, Issue 1, 2015, Pages

  Pitiyage, Gayani ^a   Lei, Mary ^b   Guererro Urbano, Teresa ^b   Odell, Edward ^a,c   Thavaraj, Selvam ^a,c  

^a GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^b ST THOMAS HOSPITAL   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Biphasic; Biphenotypic; Differentiated; Human papillomavirus; Oropharyngeal; Squamous cell carcinoma; Undifferentiated; Variant

Indexed keywords

TUMOR MARKER; VIRUS DNA;

BIOPSY; CARCINOMA, SQUAMOUS CELL; CASE REPORT; CELL DIFFERENTIATION; CHEMISTRY; CHEMORADIOTHERAPY; GENETICS; HEAD AND NECK NEOPLASMS; HUMAN; HUMAN PAPILLOMAVIRUS DNA TEST; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; OROPHARYNGEAL NEOPLASMS; PAPILLOMAVIRIDAE; PATHOLOGY; PHENOTYPE; PREDICTIVE VALUE; TREATMENT OUTCOME; VIROLOGY;

BIOMARKERS, TUMOR; BIOPSY; CARCINOMA, SQUAMOUS CELL; CELL DIFFERENTIATION; CHEMORADIOTHERAPY; DNA, VIRAL; HEAD AND NECK NEOPLASMS; HUMAN PAPILLOMAVIRUS DNA TESTS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; OROPHARYNGEAL NEOPLASMS; PAPILLOMAVIRIDAE; PHENOTYPE; PREDICTIVE VALUE OF TESTS; TREATMENT OUTCOME;

EID: 84937036272     PISSN: None     EISSN: 17461596     Source Type: Journal    
DOI: 10.1186/s13000-015-0334-9     Document Type: Article

References (25)

1. Gillison ML, D'Souza G, Westra W, Sugar E, Xiao W, Begum S, et al. Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers. J Natl Cancer Inst. 2008;100:407-20.
2. Chernock RD, El-Mofty SK, Thorstad WL, Parvin CA, Lewis Jr JS. HPV-related nonkeratinizing squamous cell carcinoma of the oropharynx: utility of microscopic features in predicting patient outcome. Head Neck Pathol. 2009;3:186-94.
3. Agrawal N, Frederick MJ, Pickering CR, Bettegowda C, Chang K, Li RJ, et al. Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science. 2011;333:1154-7.
4. Westra WH. The morphologic profile of HPV-related head and neck squamous carcinoma: implications for diagnosis, prognosis, and clinical management. Head Neck Pathol. 2012;6 Suppl 1:S48-54.
5. Chernock RD. Morphologic features of conventional squamous cell carcinoma of the oropharynx: 'keratinizing' and 'nonkeratinizing' histologic types as the basis for a consistent classification system. Head Neck Pathol. 2012;6 Suppl 1:S41-7.
6. Lewis Jr JS, Chernock RD. Human papillomavirus and Epstein Barr virus in head and neck carcinomas: suggestions for the new WHO classification. Head Neck Pathol. 2014;8:50-8.
7. Chernock RD, Lewis Jr JS, Zhang Q, El-Mofty SK. Human papillomavirus-positive basaloid squamous cell carcinomas of the upper aerodigestive tract: a distinct clinicopathologic and molecular subtype of basaloid squamous cell carcinoma. Hum Pathol. 2010;41:1016-23.
8. Jo VY, Mills SE, Stoler MH, Stelow EB. Papillary squamous cell carcinoma of the head and neck: frequent association with human papillomavirus infection and invasive carcinoma. Am J Surg Pathol. 2009;33:1720-4.
9. Masand RP, El-Mofty SK, Ma XJ, Luo Y, Flanagan JJ, Lewis Jr JS. Adenosquamous carcinoma of the head and neck: relationship to human papillomavirus and review of the literature. Head Neck Pathol. 2011;5:108-16.
10. Hanna J, Reimann JD, Haddad RI, Krane JF. Human papillomavirus-associated adenocarcinoma of the base of the tongue. Hum Pathol. 2013;44:1516-23.
11. Singhi AD, Stelow EB, Mills SE, Westra WH. Lymphoepithelial-like carcinoma of the oropharynx: a morphologic variant of HPV-related head and neck carcinoma. Am J Surg Pathol. 2010;34:800-5.
12. Bates T, McQueen A, Iqbal MS, Kelly C, Robinson M. Small cell neuroendocrine carcinoma of the oropharynx harbouring oncogenic HPV-infection. Head Neck Pathol. 2014;8:127-31.
13. Detre S, Saclani Jotti G, Dowsett M. A "quickscore" method for immunohistochemical semiquantitation: validation for oestrogen receptor in breast carcinomas. J Clin Pathol. 1995;48:876-8.
14. Rainsbury JW, Ahmed W, Williams HK, Roberts S, Paleri V, Mehanna H. Prognostic biomarkers of survival in oropharyngeal squamous cell carcinoma: systematic review and meta-analysis. Head Neck. 2013;35:1048-55.
15. Robinson M, Schache A, Sloan P, Thavaraj S. HPV specific testing: a requirement for oropharyngeal squamous cell carcinoma patients. Head Neck Pathol. 2012;6 Suppl 1:S83-90.
16. Lewis Jr JS, Khan RA, Masand RP, Chernock RD, Zhang Q, Al-Naief NS, et al. Recognition of nonkeratinizing morphology in oropharyngeal squamous cell carcinoma - a prospective cohort and interobserver variability study. Histopathology. 2012;60:427-36.
17. El-Mofty SK. HPV-related squamous cell carcinoma variants in the head and neck. Head and neck pathology. 2012;6 Suppl 1:S55-62.
18. Bishop JA, Westra WH. Human papillomavirus-related small cell carcinoma of the oropharynx. Am J Surg Pathol. 2011;35:1679-84.
19. Begum S, Westra WH. Basaloid squamous cell carcinoma of the head and neck is a mixed variant that can be further resolved by HPV status. Am J Surg Pathol. 2008;32:1044-50.
20. Kraft S, Faquin WC, Krane JF. HPV-associated neuroendocrine carcinoma of the oropharynx: a rare new entity with potentially aggressive clinical behavior. Am J Surg Pathol. 2012;36:321-30.
21. Barnes L. Pathology and genetics of head and neck tumours. Lyon: IARC Press; 2005.
22. Bishop JA, Ma XJ, Wang H, Luo Y, Illei PB, Begum S, et al. Detection of transcriptionally active high-risk HPV in patients with head and neck squamous cell carcinoma as visualized by a novel E6/E7 mRNA in situ hybridization method. Am J Surg Pathol. 2012;36:1874-82.
23. Ritta M, Landolfo V, Mazibrada J, De Andrea M, Dell'Oste V, Caneparo V, et al. Human papillomavirus tumor-infiltrating T-regulatory lymphocytes and P53 codon 72 polymorphisms correlate with clinical staging and prognosis of oropharyngeal cancer. New Microbiol. 2013;36:133-44.
24. Nordfors C, Grun N, Tertipis N, Ahrlund-Richter A, Haeggblom L, Sivars L, et al. CD8+ and CD4+ tumour infiltrating lymphocytes in relation to human papillomavirus status and clinical outcome in tonsillar and base of tongue squamous cell carcinoma. Eur J Cancer. 2013;49:2522-30.
25. King EV, Ottensmeier CH, Thomas GJ. The immune response in HPV oropharyngeal cancer. Oncoimmunology. 2014;3, e27254.