Development of a toxicogenomics signature for genotoxicity using a dose-optimization and informatics strategy in human cells

Environmental and Molecular Mutagenesis

Volumn 56, Issue 6, 2015, Pages 505-519

  Li, Heng Hong ^a   Hyduke, Daniel R ^a,b   Chen, Renxiang ^a   Heard, Pamela ^c   Yauk, Carole L ^d   Aubrecht, Jiri ^c   Fornace, Albert J ^a,e  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b Utah State University   (United States)

^c PFIZER INC   (United States)

^d HEALTH CANADA   (Canada)

^e KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

Bioinformatics; DNA damage inducible; Stress genes; Super paramagnetic clustering

Indexed keywords

ARTICLE; CYTOTOXICITY; GENE EXPRESSION; GENETIC MARKER; GENETIC RISK; GENOTOXICITY; HUMAN; HUMAN CELL; INFORMATION SCIENCE; MICROARRAY ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RISK ASSESSMENT; STRESS; UNITED STATES; CELL LINE; CLUSTER ANALYSIS; DNA MICROARRAY; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENETIC DATABASE; GENETICS; MUTAGEN TESTING; PROCEDURES; REPRODUCIBILITY; TOXICOGENETICS;

ANIMALIA;

3-NITROPROPIONIC ACID; ACTIVATING TRANSCRIPTION FACTOR 3; ATF3 PROTEIN, HUMAN; CAFFEINE; CDKN1A PROTEIN, HUMAN; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; GADD45A PROTEIN, HUMAN; GENETIC MARKER; ISOPROPYLMETHANESULFONATE; MESYLIC ACID DERIVATIVE; NITRO DERIVATIVE; NUCLEAR PROTEIN; PROPIONIC ACID DERIVATIVE;

ACTIVATING TRANSCRIPTION FACTOR 3; CAFFEINE; CELL CYCLE PROTEINS; CELL LINE; CLUSTER ANALYSIS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DATABASES, GENETIC; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION PROFILING; GENETIC MARKERS; HUMANS; MESYLATES; MUTAGENICITY TESTS; NITRO COMPOUNDS; NUCLEAR PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROPIONATES; REAL-TIME POLYMERASE CHAIN REACTION; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; TOXICOGENETICS;

EID: 84937023634     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.21941     Document Type: Article

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