The association between NFKB1-94ins/del ATTG polymorphism and non-small cell lung cancer risk in a Chinese Han population

International Journal of Clinical and Experimental Medicine

Volumn 8, Issue 5, 2015, Pages 8153-8157

  Wang, Yue ^a   Chen, Libo ^a   Pan, Liming ^b   Xue, Jinru ^a   Yu, Haixiang ^a  

^a CHINA JAPAN UNION HOSPITAL OF JILIN UNIVERSITY   (China)

^b THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

Author keywords

Genetics; Non small cell lung cancer; Nuclear factor B; Polymorphism

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

ADULT; ALLELE; ARTICLE; CANCER RISK; CANCER STAGING; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE DELETION; GENE FREQUENCY; GENE INSERTION; GENETIC ASSOCIATION; GENOTYPING TECHNIQUE; HUMAN; MAJOR CLINICAL STUDY; MALE; NON SMALL CELL LUNG CANCER; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

EID: 84936992814     PISSN: None     EISSN: 19405901     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. [1] Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin 2013; 63: 11-30.
2. [2] Pastorino U. Lung cancer screening. Br J Cancer 2010; 102: 1681-6.
3. [3] Sen R, Baltimore D. Inducibility of K immunoglobulin enhancer-binding protein NF-kB by a posttranslational mechanism. Cell 1986; 47: 921-8.
4. [4] Chen F, Castranova V, Shi X, Demers LM. New insights into the role of nuclear factor-kappaB, a ubiquitous transcription factor in the initiation of diseases. Clin Chem 1999; 45: 7-17.
5. [5] Sun XF, Zhang H. NFKB and NFKBI polymorphisms in relation to susceptibility of tumour and other diseases. Histol Histopathol 2007; 22: 1387-98.
6. [6] Karban AS, Okazaki T, Panhuysen CI, Gallegos T, Potter JJ, Bailey-Wilson JE, Silverberg MS, Duerr RH, Cho JH, Gregersen PK, Wu Y, Achkar JP, Dassopoulos T, Mezey E, Bayless TM, Nouvet FJ, Brant SR. Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis. Hum Mol Genet 2004; 13: 35-45.
7. [7] Song S, Chen D, Lu J, Liao J, Luo Y, Yang Z, Fu X, Fan X, Wei Y, Yang L, Wang L, Wang J. NFκB1 and NFκBIA polymorphisms are associated with increased risk for sporadic colorectal cancer in a southern Chinese population. PLoS One 2011; 6: e21726.
8. [8] López-Mejías R, García-Bermúdez M, González-Juanatey C, Castañeda S, Miranda-Filloy JA, Gómez-Vaquero C, Fernández-Gutiérrez B, Ba-lsa A, Pascual-Salcedo D, Blanco R, González-Álvaro I, Llorca J, Martín J, González-Gay MA. NFKB1-94ATTG ins/del polymorphism (rs28-362491) is associated with cardiovascular disease in patients with rheumatoid arthritis. Atherosclerosis 2012; 224: 426-9.
9. [9] Mukhopadhyay T, Roth JA, Maxwell SA. Altered expression of the p50 subunit of the NF-kappa B transcription factor complex in non-small cell lung carcinoma. Oncogene 1995; 11: 999-1003.
10. [10] Bours V, Dejardin E, Goujon-Letawe F, Merville MP, Castronovo V. The NF-kappa B transcription factor and cancer: high expression of NF-kappa B- and I kappa B-related proteins in tumor cell lines. Biochem Pharmacol 1994; 47: 145-9.
11. [11] Yu Y, Wan Y, Huang C. The biological functions of NF-kappaB1 (p50) and its potential as an anti-cancer target. Curr Cancer Drug Targets 2009; 9: 566-71.
12. [12] Maria TG, Vasileios KE, Panagiotis PS, Kostas SN. Changes of acute-phase protein levels in the serum of lung cancer patients following radiotherapy. Int J Clin Exp Med 2013; 6: 50-6.
13. [13] Nikolaos T, Maria T, Ioannis KD, Georgios L, Nikolaos P, Stamatina D, Christos P, Georgios K, Vasileios B, Anna E. Dermatomyositis as an early manifestation and a significant clinical precursor of lung cancer: report of a rare case and review of the current literature. Int J Clin Exp Med 2013; 6: 105-9.