From Dish to Bedside: Lessons Learned while Translating Findings from a Stem Cell Model of Disease to a Clinical Trial

Cell Stem Cell

Volumn 17, Issue 1, 2015, Pages 8-10

  McNeish, John ^a   Gardner, Jason P ^a   Wainger, Brian J ^b,c   Woolf, Clifford J ^c,d   Eggan, Kevin ^c,e,f  

^a GLAXOSMITHKLINE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HARVARD STEM CELL INSTITUTE   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e Harvard University   (United States)

^f MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; COPPER ZINC SUPEROXIDE DISMUTASE; DELAYED RECTIFIER POTASSIUM CHANNEL; GLUTAMIC ACID; RETIGABINE; RILUZOLE; CARBAMIC ACID DERIVATIVE; PHENYLENEDIAMINE DERIVATIVE; SUPEROXIDE DISMUTASE;

ACTION POTENTIAL; AMYOTROPHIC LATERAL SCLEROSIS; CELL SURVIVAL; CLINICAL TRIAL (TOPIC); DECISION MAKING; DISEASE COURSE; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG MECHANISM; DRUG RESPONSE; EMBRYONIC STEM CELL; EPILEPSY; GENE MUTATION; GENETIC HETEROGENEITY; HUMAN; IN VITRO STUDY; MOTONEURON; NERVE CONDUCTION; NONHUMAN; PATIENT ADVOCACY; PHENOTYPE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROGNOSIS; REVIEW; THERAPY EFFECT; TRANSCRANIAL MAGNETIC STIMULATION; ANIMAL; BIOLOGICAL MODEL; DRUG DEVELOPMENT; DRUG EFFECTS; GENETICS; INDUCED PLURIPOTENT STEM CELL; MOUSE; MUTATION; PATHOPHYSIOLOGY; PHYSIOLOGY; TRANSLATIONAL RESEARCH;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CARBAMATES; CLINICAL TRIALS AS TOPIC; DRUG DISCOVERY; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MICE; MODELS, NEUROLOGICAL; MOTOR NEURONS; MUTATION; PHENYLENEDIAMINES; SUPEROXIDE DISMUTASE; TRANSLATIONAL MEDICAL RESEARCH;

EID: 84936990375     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2015.06.013     Document Type: Note

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