Regulation of UHRF1 by microRNA-9 modulates colorectal cancer cell proliferation and apoptosis

Cancer Science

Volumn 106, Issue 7, 2015, Pages 833-839

  Zhu, Mingchen ^a,b   Xu, Yijun ^b   Ge, Mengyuan ^a   Gui, Zhen ^a   Yan, Feng ^a  

^a JIANGSU CANCER HOSPITAL   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Colorectal cancer; MiR 9; Prognosis; Tumorigenesis; UHRF1

Indexed keywords

GENOMIC DNA; MICRORNA; MICRORNA 9; UBIQUITIN; UBIQUITIN LIKE WITH PLANT HOMEODOMAIN AND RING FINGER DOMAIN 1; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; CCAAT ENHANCER BINDING PROTEIN; MIRN92 MICRORNA, HUMAN; UHRF1 PROTEIN, HUMAN;

ADULT; AGED; APOPTOSIS; ARTICLE; CANCER SURVIVAL; CELL PROLIFERATION; CELL VIABILITY; COLON CARCINOGENESIS; COLONY FORMATION; COLORECTAL CANCER; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; VERY ELDERLY; 3' UNTRANSLATED REGION; BINDING SITE; COLORECTAL TUMOR; GENE EXPRESSION REGULATION; GENETICS; HCT116 CELL LINE; HT 29 CELL LINE; KAPLAN MEIER METHOD; METABOLISM; MIDDLE AGED; MORTALITY; NUCLEOTIDE SEQUENCE; PATHOLOGY; PHYSIOLOGY; PROGNOSIS; RNA INTERFERENCE;

3' UNTRANSLATED REGIONS; AGED; AGED, 80 AND OVER; APOPTOSIS; BASE SEQUENCE; BINDING SITES; CCAAT-ENHANCER-BINDING PROTEINS; CELL PROLIFERATION; COLORECTAL NEOPLASMS; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HT29 CELLS; HUMANS; KAPLAN-MEIER ESTIMATE; MICRORNAS; MIDDLE AGED; PROGNOSIS; RNA INTERFERENCE;

EID: 84936986124     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/cas.12689     Document Type: Article

References (36)

1. Jemal A, Bray F, Center MM et al. Global cancer statistics. CA Cancer J Clin 2011; 61: 69-90.
2. Peltomaki P. Role of DNA mismatch repair defects in the pathogenesis of human cancer. J Clin Oncol 2003; 21: 1174-9.
3. Yun J, Rago C, Cheong I et al. Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells. Science 2009; 325: 1555-9.
4. Kim TM, Laird PW, Park PJ. The landscape of microsatellite instability in colorectal and endometrial cancer genomes. Cell 2013; 155: 858-68.
5. Bostick M, Kim JK, Esteve PO et al. UHRF1 plays a role in maintaining DNA methylation in mammalian cells. Science 2007; 317: 1760-4.
6. Wang F, Yang Y-Z, Shi C-Z et al. UHRF1 promotes cell growth and metastasis through repression of p16ink4a in colorectal cancer. Ann Surg Oncol 2012; 19: 2753-62.
7. Hashimoto H, Horton JR, Zhang X et al. UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications. Epigenetics 2009; 4: 8-14.
8. Achour M, Jacq X, Ronde P et al. The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression. Oncogene 2008; 27: 2187-97.
9. Unoki M, Nishidate T, Nakamura Y. ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain. Oncogene 2004; 23: 7601-10.
10. Karagianni P, Amazit L, Qin J et al. ICBP90, a novel methyl K9 H3 binding protein linking protein ubiquitination with heterochromatin formation. Mol Cell Biol 2008; 28: 705-17.
11. Mudbhary R, Hoshida Y, Chernyavskaya Y et al. UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma. Cancer Cell 2014; 25: 196-209.
12. Babbio F, Pistore C, Curti L et al. The SRA protein UHRF1 promotes epigenetic crosstalks and is involved in prostate cancer progression. Oncogene 2012; 31: 4878-87.
13. Kumamoto K. UHRF1 expression is upregulated and associated with cellular proliferation in colorectal cancer. Oncol Rep 2012; 28: 1997-2002.
14. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116: 281-97.
15. Krol J, Loedige I, Filipowicz W. The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet 2010; 11: 597-610.
16. Michael MZ, O'Connor SM, van Holst Pellekaan NG et al. Reduced accumulation of specific microRNAs in colorectal neoplasia. Mol Cancer Res 2003; 1: 882-91.
17. Volinia S, Calin GA, Liu CG et al. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A 2006; 103: 2257-61.
18. Cekaite L, Rantala JK, Bruun J et al. MiR-9, -31, and -182 deregulation promote proliferation and tumor cell survival in colon cancer. Neoplasia 2012; 14: 868-79.
19. Valeri N, Braconi C, Gasparini P et al. MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer. Cancer Cell 2014; 25: 469-83.
20. Rokavec M, Oner MG, Li H et al. IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. J Clin Investig 2014; 124: 1853-67.
21. Slaby O, Svoboda M, Michalek J et al. MicroRNAs in colorectal cancer: translation of molecular biology into clinical application. Mol Cancer 2009; 8: 102.
22. Padi SK, Zhang Q, Rustum YM et al. MicroRNA-627 mediates the epigenetic mechanisms of vitamin D to suppress proliferation of human colorectal cancer cells and growth of xenograft tumors in mice. Gastroenterology 2013; 145: 437-46.
23. Chen DL, Wang ZQ, Zeng ZL et al. Identification of microRNA-214 as a negative regulator of colorectal cancer liver metastasis by way of regulation of fibroblast growth factor receptor 1 expression. Hepatology 2014; 60: 598-609.
24. Lim L, Balakrishnan A, Huskey N et al. MicroRNA-494 within an oncogenic microRNA megacluster regulates G1/S transition in liver tumorigenesis through suppression of mutated in colorectal cancer. Hepatology 2014; 59: 202-15.
25. Bandres E, Agirre X, Bitarte N et al. Epigenetic regulation of microRNA expression in colorectal cancer. Int J Cancer 2009; 125: 2737-43.
26. Oberg AL, French AJ, Sarver AL et al. miRNA expression in colon polyps provides evidence for a multihit model of colon cancer. PLoS One 2011; 6: e20465.
27. Zhu L, Chen H, Zhou D et al. MicroRNA-9 up-regulation is involved in colorectal cancer metastasis via promoting cell motility. Med Oncol 2012; 29: 1037-43.
28. Tagawa T, Haraguchi T, Hiramatsu H et al. Multiple microRNAs induced by Cdx1 suppress Cdx2 in human colorectal tumour cells. Biochem J 2012; 447: 449-55.
29. Lu MH, Huang CC, Pan MR et al. Prospero homeobox 1 promotes epithelial-mesenchymal transition in colon cancer cells by inhibiting E-cadherin via miR-9. Clin Cancer Res 2012; 18: 6416-25.
30. Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet 2002; 3: 415-28.
31. Kim JK, Esteve PO, Jacobsen SE et al. UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells. Nucleic Acids Res 2009; 37: 493-505.
32. Mousli M, Hopfner R, Abbady AQ et al. ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells. Br J Cancer 2003; 89: 120-7.
33. Unoki M, Kelly JD, Neal DE et al. UHRF1 is a novel molecular marker for diagnosis and the prognosis of bladder cancer. Br J Cancer 2009; 101: 98-105.
34. Unoki M, Daigo Y, Koinuma J et al. UHRF1 is a novel diagnostic marker of lung cancer. Br J Cancer 2010; 103: 217-22.
35. Yu T, Liu K, Wu Y et al. MicroRNA-9 inhibits the proliferation of oral squamous cell carcinoma cells by suppressing expression of CXCR4 via the Wnt/beta-catenin signaling pathway. Oncogene 2014; 33: 5017-27.
36. Emmrich S, Katsman-Kuipers JE, Henke K et al. miR-9 is a tumor suppressor in pediatric AML with t(8;21). Leukemia 2014; 28: 1022-32.