메뉴 건너뛰기




Volumn 8, Issue , 2015, Pages 189-196

Saroglitazar for the treatment of hypertriglyceridemia in patients with type 2 diabetes: Current evidence

Author keywords

Atherosclerosis; Cardiovascular disease; Diabetes mellitus; Dyslipidemia; PPAR agonists

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN A2; APOLIPOPROTEIN B; APOLIPOPROTEIN C3; CHOLESTEROL ESTER TRANSFER PROTEIN; FATTY ACID; FIBRIC ACID DERIVATIVE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIPOPROTEIN LIPASE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NICOTINIC ACID; OMEGA 3 FATTY ACID; PIOGLITAZONE; SAROGLITAZAR; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

EID: 84936940284     PISSN: None     EISSN: 11787007     Source Type: Journal    
DOI: 10.2147/DMSO.S49592     Document Type: Review
Times cited : (52)

References (27)
  • 1
    • 0037126526 scopus 로고    scopus 로고
    • Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report
    • National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
    • National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 2002;106(25):3143-3421.
    • (2002) Circulation. , vol.106 , Issue.25 , pp. 3143-3421
  • 2
    • 0025118667 scopus 로고
    • Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk
    • Austin MA, King MC, Vranizan KM, Krauss RM. Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk. Circulation. 1990;82(2):495-506.
    • (1990) Circulation. , vol.82 , Issue.2 , pp. 495-506
    • Austin, M.A.1    King, M.C.2    Vranizan, K.M.3    Krauss, R.M.4
  • 3
    • 77951875017 scopus 로고    scopus 로고
    • Triglyceride-mediated pathways and coronary disease: Collaborative analysis of 101 studies
    • Triglyceride Coronary Disease Genetics Consortium and Emerging Risk Factors Collaboration. Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies. Lancet. 2010;375(9726): 1634-1639.
    • (2010) Lancet. , vol.375 , Issue.9726 , pp. 1634-1639
  • 4
    • 79956218817 scopus 로고    scopus 로고
    • Serum non-high-density lipoprotein cholesterol concentration and risk of death from cardiovascular diseases among US adults with diagnosed diabetes: The Third National Health and Nutrition Examination Survey linked mortality study
    • Li C, Ford ES, Tsai J, Zhao G, Balluz LS, Gidding SS. Serum non-high-density lipoprotein cholesterol concentration and risk of death from cardiovascular diseases among US adults with diagnosed diabetes: the Third National Health and Nutrition Examination Survey linked mortality study. Cardiovasc Diabetol. 2011;10:46.
    • (2011) Cardiovasc Diabetol. , vol.10 , pp. 46
    • Li, C.1    Ford, E.S.2    Tsai, J.3    Zhao, G.4    Balluz, L.S.5    Gidding, S.S.6
  • 5
    • 33644861577 scopus 로고    scopus 로고
    • Increased small low-density lipoprotein particle number: A prominent feature of the metabolic syndrome in the Framingham Heart Study
    • Kathiresan S, Otvos JD, Sullivan LM, et al. Increased small low-density lipoprotein particle number: a prominent feature of the metabolic syndrome in the Framingham Heart Study. Circulation. 2006;113(1): 20-29.
    • (2006) Circulation. , vol.113 , Issue.1 , pp. 20-29
    • Kathiresan, S.1    Otvos, J.D.2    Sullivan, L.M.3
  • 6
    • 84891846448 scopus 로고    scopus 로고
    • The nuances of atherogenic dyslipidemia in diabetes: Focus on triglycerides and current management strategies
    • Manoria PC, Chopra HK, Parashar SK, et al. The nuances of atherogenic dyslipidemia in diabetes: focus on triglycerides and current management strategies. Indian Heart J. 2013;65(6):683-690.
    • (2013) Indian Heart J. , vol.65 , Issue.6 , pp. 683-690
    • Manoria, P.C.1    Chopra, H.K.2    Parashar, S.K.3
  • 7
    • 78951495282 scopus 로고    scopus 로고
    • Small dense LDL particles - A predictor of coronary artery disease evaluated by invasive and CT-based techniques: A case-control study
    • Toft-Petersen AP1, Tilsted HH, Aarøe J, et al. Small dense LDL particles - a predictor of coronary artery disease evaluated by invasive and CT-based techniques: a case-control study. Lipids Health Dis. 2011;10:21.
    • (2011) Lipids Health Dis. , vol.10 , pp. 21
    • Toft-Petersen, A.P.1    Tilsted, H.H.2    Aarøe, J.3
  • 8
    • 4344683381 scopus 로고    scopus 로고
    • Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): Multicentre randomised placebo-controlled trial
    • Colhoun HM, Betteridge DJ, Durrington PN, et al. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial. Lancet. 2004;364(9435):685-696.
    • (2004) Lancet. , vol.364 , Issue.9435 , pp. 685-696
    • Colhoun, H.M.1    Betteridge, D.J.2    Durrington, P.N.3
  • 9
    • 0037840242 scopus 로고    scopus 로고
    • MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 5963 people with diabetes: A randomised placebo controlled trial
    • Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 5963 people with diabetes: a randomised placebo controlled trial Lancet. 2003;361: 2005-2016.
    • (2003) Lancet. , vol.361 , pp. 2005-2016
  • 10
    • 84868533549 scopus 로고    scopus 로고
    • Effects of fibrates in kidney disease: A systematic review and meta-analysis
    • Jun M, Zhu B, Tonelli M, et al, Effects of fibrates in kidney disease: a systematic review and meta-analysis. J Am Coll Cardiol. 2012;60(20): 2061-2071.
    • (2012) J Am Coll Cardiol. , vol.60 , Issue.20 , pp. 2061-2071
    • Jun, M.1    Zhu, B.2    Tonelli, M.3
  • 11
    • 33845638272 scopus 로고    scopus 로고
    • Excerpts from the United States Renal Data System 2006 Annual Data Report
    • Collins AJ, Kasiske B, Herzog C, et al. Excerpts from the United States Renal Data System 2006 Annual Data Report. Am J Kidney Dis. 2007;49(1 Suppl 1):A6-A7, S1-S296.
    • (2007) Am J Kidney Dis. , vol.49 , Issue.1
    • Collins, A.J.1    Kasiske, B.2    Herzog, C.3
  • 12
    • 9644252909 scopus 로고    scopus 로고
    • Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs
    • Graham DJ, Staffa JA, Shatin D, et al. Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs. JAMA. 2004;292(21):2585-2590.
    • (2004) JAMA. , vol.292 , Issue.21 , pp. 2585-2590
    • Graham, D.J.1    Staffa, J.A.2    Shatin, D.3
  • 13
    • 84865338549 scopus 로고    scopus 로고
    • Lipid-modifying therapies and risk of pancreatitis: A meta-analysis
    • Preiss D, Tikkanen MJ, Welsh P, et al. Lipid-modifying therapies and risk of pancreatitis: a meta-analysis. JAMA. 2012;308(8):804-811.
    • (2012) JAMA. , vol.308 , Issue.8 , pp. 804-811
    • Preiss, D.1    Tikkanen, M.J.2    Welsh, P.3
  • 15
    • 84855171302 scopus 로고    scopus 로고
    • Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy
    • AIM-HIGH Investigators. Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy. N Engl J Med. 2011;365(24): 2255-2267.
    • (2011) N Engl J Med. , vol.365 , Issue.24 , pp. 2255-2267
    • AIM-HIGH Investigators1
  • 16
    • 84877299845 scopus 로고    scopus 로고
    • HPS2-THRIVE randomized placebo-controlled trial in 25 673 high-risk patients of ER niacin/laropiprant: Trial design, pre-specified muscle and liver outcomes, and reasons for stopping study treatment
    • HPS2-THRIVE Collaborative Group. HPS2-THRIVE randomized placebo-controlled trial in 25 673 high-risk patients of ER niacin/laropiprant: trial design, pre-specified muscle and liver outcomes, and reasons for stopping study treatment. Eur Heart J. 2013;34(17): 1279-1291.
    • (2013) Eur Heart J. , vol.34 , Issue.17 , pp. 1279-1291
  • 17
    • 33947583493 scopus 로고    scopus 로고
    • Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): A randomised open-label, blinded endpoint analysis
    • Yokoyama M, Origasa H, Matsuzaki M, et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet. 2007;369(9567):1090-1098.
    • (2007) Lancet. , vol.369 , Issue.9567 , pp. 1090-1098
    • Yokoyama, M.1    Origasa, H.2    Matsuzaki, M.3
  • 18
    • 64749095070 scopus 로고    scopus 로고
    • Effects of fenofibrate treatment on cardiovascular disease risk in 9,795 individuals with type 2 diabetes and various components of the metabolic syndrome: The Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study
    • Scott R, O'Brien R, Fulcher G, et al. Effects of fenofibrate treatment on cardiovascular disease risk in 9,795 individuals with type 2 diabetes and various components of the metabolic syndrome: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study. Diabetes Care. 2009;32(3):493-498.
    • (2009) Diabetes Care. , vol.32 , Issue.3 , pp. 493-498
    • Scott, R.1    O'Brien, R.2    Fulcher, G.3
  • 19
    • 77951704587 scopus 로고    scopus 로고
    • Effects of combination lipid therapy in type 2 diabetes mellitus
    • ACCORD Study Group, Ginsberg HN, Elam MB, Lovato LC, et al, Effects of combination lipid therapy in type 2 diabetes mellitus. N Engl J Med. 2010;362(17):1563-1564.
    • (2010) N Engl J Med. , vol.362 , Issue.17 , pp. 1563-1564
    • Ginsberg, H.N.1    Elam, M.B.2    Lovato, L.C.3
  • 20
    • 84867235189 scopus 로고    scopus 로고
    • Fibrates are an essential part of modern anti-dyslipidemic arsenal: Spotlight on atherogenic dyslipidemia and residual risk reduction
    • Tenenbaum A, Fisman EZ. Fibrates are an essential part of modern anti-dyslipidemic arsenal: spotlight on atherogenic dyslipidemia and residual risk reduction. Cardiovasc Diabetol. 2012;11:125.
    • (2012) Cardiovasc Diabetol. , vol.11 , pp. 125
    • Tenenbaum, A.1    Fisman, E.Z.2
  • 21
    • 79960539641 scopus 로고    scopus 로고
    • ESC/EAS Guidelines for the management of dyslipidaemias: The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS)
    • Catapano AL, Reiner Z, De Backer G, et al. ESC/EAS Guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Eur Heart J. 2011;32(14): 1769-1818.
    • (2011) Eur Heart J. , vol.32 , Issue.14 , pp. 1769-1818
    • Catapano, A.L.1    Reiner, Z.2    De Backer, G.3
  • 22
    • 23644456172 scopus 로고    scopus 로고
    • Therapeutic roles of peroxisome proliferator-activated receptor agonists
    • Staels B, Fruchart JC. Therapeutic roles of peroxisome proliferator-activated receptor agonists. Diabetes. 2005;54(8):2460-2470.
    • (2005) Diabetes. , vol.54 , Issue.8 , pp. 2460-2470
    • Staels, B.1    Fruchart, J.C.2
  • 25
    • 84886402812 scopus 로고    scopus 로고
    • Pharmacokinetics, safety, and tolerability of saroglitazar (ZYH1), a predominantly PPARα agonist with moderate PPARγ agonist activity in healthy human subjects
    • Jani RH, Kansagra K, Jain MR, Patel H. Pharmacokinetics, safety, and tolerability of saroglitazar (ZYH1), a predominantly PPARα agonist with moderate PPARγ agonist activity in healthy human subjects. Clin Drug Investig. 2013;33(11):809-816.
    • (2013) Clin Drug Investig. , vol.33 , Issue.11 , pp. 809-816
    • Jani, R.H.1    Kansagra, K.2    Jain, M.R.3    Patel, H.4
  • 26
    • 84900559988 scopus 로고    scopus 로고
    • A multicenter, prospective, randomized, double-blind study to evaluate the safety and efficacy of saroglitazar 2 and 4 mg compared to pioglitazone 45 mg in diabetic dyslipidemia (PRESS V)
    • Pai V, Paneerselvam A, Mukhopadhyay S, et al. A multicenter, prospective, randomized, double-blind study to evaluate the safety and efficacy of saroglitazar 2 and 4 mg compared to pioglitazone 45 mg in diabetic dyslipidemia (PRESS V). J Diabetes Sci Technol. 2014;8(1): 132-141.
    • (2014) J Diabetes Sci Technol. , vol.8 , Issue.1 , pp. 132-141
    • Pai, V.1    Paneerselvam, A.2    Mukhopadhyay, S.3
  • 27
    • 84892637705 scopus 로고    scopus 로고
    • A multicenter, prospective, randomized, double-blind study to evaluate the safety and efficacy of saroglitazar 2 and 4 mg compared with placebo in type 2 diabetes mellitus patients having hypertriglyceridemia not controlled with atorvastatin therapy (PRESS VI)
    • Jani RH, Pai V, Jha P, et al. A multicenter, prospective, randomized, double-blind study to evaluate the safety and efficacy of saroglitazar 2 and 4 mg compared with placebo in type 2 diabetes mellitus patients having hypertriglyceridemia not controlled with atorvastatin therapy (PRESS VI). Diabetes Technol Ther. 2014;16(2):63-71.
    • (2014) Diabetes Technol Ther. , vol.16 , Issue.2 , pp. 63-71
    • Jani, R.H.1    Pai, V.2    Jha, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.