Childhood sexual abuse and impulsive personality traits: Mixed evidence for moderation by DRD4 genotype

Journal of Research in Personality

Volumn 55, Issue , 2015, Pages 30-40

  Harden, K Paige ^a   Carlson, Marie D ^a   Kretsch, Natalie ^a   Corbin, William R ^b   Fromme, Kim ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b ARIZONA STATE UNIVERSITY   (United States)

Author keywords

Childhood sexual abuse; Diathesis stress; Differential susceptibility; DRD4; Gene environment interaction; Impulsivity; Sensation seeking

Indexed keywords

EID: 84936933210     PISSN: 00926566     EISSN: 10957251     Source Type: Journal    
DOI: 10.1016/j.jrp.2014.12.005     Document Type: Article

References (66)

1. American Psychiatric Association Diagnostic and statistical manual of mental disorders 2013, American Psychiatric Publishing, Arlington, VA. 5th ed.
2. Anestis M.D., Smith A.R., Fink E.L., Joiner T.E. Dysregulated eating and distress: Examining the specific role of negative urgency in a clinical sample. Cognitive Therapy and Research 2009, 33:390-397.
3. Asghari V., Sanyal S., Buchwaldt S., Paterson A., Jovanovic V., Van Tol H.H. Modulation of intercellular cyclic AMP levels by different human dopamine D4 receptor variants. Journal of Neurochemistry 1995, 65(1):157-1165.
4. Bakermans-Kranenburg M.J., van Ijzendoorn M.H. Differential susceptibility to rearing environment depending on dopamine-related genes: New evidence and a meta-analysis. Development and Psychopathology 2011, 23:39-52. 10.1017/S0954579410000635.
5. Becker K., Laucht M., El-Faddagh M., Schmidt M.H. The dopamine D4 receptor gene exon III polymorphism is associated with novelty seeking in 15-year-old males from a high-risk community sample. Journal of Neural Transmission 2005, 112:847-858. 10.1007/s00702-004-0223-y.
6. Belsky J., Bakermans-Kranenburg M.J., Van Ijzendoorn M.H. For better and for worse: Differential susceptibility to environmental influences. Current Directions in Psychological Science 2007, 16:300-304. 10.1111/j.1467-8721.2007.00525.x.
7. Bergevin T.A., Bukowski W.M., Karavasilis L. Childhood sexual abuse and pubertal timing: Implications for long-term psychosocial adjustment. Gender differences at puberty 2003, 187-216. Cambridge University Press, Cambridge, UK. C. Hayward (Ed.).
8. Bornovalova M.A., Gwadz M.A., Kahler C., Aklin W.M., Lejuez C.W. Sensation seeking and risk-taking propensity as mediators in the relationship between childhood abuse and HIV-related risk behavior. Child Abuse and Neglect 2008, 32:99-109. 10.1016/j.chiabu.2007.04.009.
9. Bromberg-Martin E.S., Matsumoto M., Hikosaka O. Dopamine in motivational control: Rewarding, aversive, and alerting. Neuron 2010, 68:815-834. 10.1016/j.neuron.2010.11.022.
10. Charnigo R., Noar S.M., Garnett C., Crosby R., Palmgreen P., Zimmerman R.S. Sensation seeking and impulsivity: Combined associations with risky sexual behavior in a large sample of young adults. Journal of Sex Research 2013, 50:480-488. 10.1080/00224499.
11. Cloninger C.R. A systematic method for clinical description and classification of personality variants. Archives of General Psychiatry 1987, 44:573-588.
12. Corbin W.R., Vaughan E.L., Fromme K. Ethnic differences and the closing of the sex gap in alcohol use among college-bound students. Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors 2008, 22:240-248. 10.1037/a0013335.
13. Cyders M.A., Smith G.T. Emotion-based dispositions to rash action: Positive and negative urgency. Psychological Bulletin 2008, 134:807-828.
14. Davis C., Loxton N.J. Addictive behaviors and addiction-prone personality traits: Associations with a dopamine multilocus genetic profile. Addictive Behaviors 2013, 38:2306-2312. 10.1016/j.addbeh.2013.02.012.
15. Deckman T., DeWall C.N. Negative urgency and risky sexual behaviors: A clarification of the relationship between impulsivity and risky sexual behavior. Personality and Individual Differences 2011, 51:674-678.
16. Depue R.A., Collins P.F. Neurobiology of the structure of personality: Dopamine, facilitation of incentive motivation, and extraversion. The Behavioral and Brain Sciences 1999, 22(3):491-517. 10.107/S0140525x99002046.
17. Derringer J., Krueger R.F., Dick D.M., Saccone S., Grucza R.A., Agrawal A., et al. Predicting sensation seeking from dopamine genes: A candidate-system approach. Psychological Science 2010, 21:1282-1290.
18. DeYoung C.G. The neuromodulator of exploration: A unifying theory of the role of dopamine in personality. Frontiers in Human Neuroscience 2013, 7. Article 762. 10.3389/fnhum.2013.00762.
19. Donohew L., Zimmerman R., Cupp P.S., Novak S., Colon S., Abell R. Sensation seeking, impulsive decision-making, and risky sex: Implications for risk-taking and design of interventions. Personality and Individual Differences 2000, 28:1079-1091.
20. Dreber A., Apicella C.L., Eisenberg D.T., Garcia J.R., Zamore R.S., Lum J.K., et al. The 7R polymorphism in the dopamine receptor D4 gene (DRD4) is associated with financial risk taking in men. Evolution and Human Behavior 2009, 30:85-92.
21. Dulawa S.C., Grandy D.K., Low M.J., Paulus M.P., Geyer M.A. Dopamine D4 receptor-knock-out mice exhibit reduced exploration of novel stimuli. The Journal of Neuroscience: The Official Journal of The Society for Neuroscience 1999, 19:9550-9556.
22. Duncan L.E., Keller M.C. A critical review of the first 10 years of candidate gene-by-environment interaction research in psychiatry. American Journal of Psychiatry 2011, 168:1041-1049. 10.1176/appi.ajp.2011.11020191.
23. Eaton D.K., Davis K.S., Barrios L., Brener N.D., Noonan R.K. Associations of dating violence victimization with lifetime participation, co-occurrence, and early initiation of risk behaviors among US high school students. Journal of Interpersonal Violence 2007, 22:585-602.
24. Ellingson J.M., Verges A., Littlefield A.K., Martin N.G., Slutske W.S. Are bottom-up and top-down traits in dual-systems models of risky behavior genetically distinct?. Behavior Genetics 2013, 43:480-490.
25. Fulker D.W., Eysenck S.B., Zuckerman M. A genetic and environmental analysis of sensation seeking. Journal of Research in Personality 1980, 14:261-281. 10.1016/0092-6566(80)90033-1.
26. Hall N.J., Wynne C.D.L. The canid genome: Behavioral geneticists' best friend?. Genes, Brain and Behavior 2012, 11:889-890. 10.1111/j.1601-183X.2012.00851.x.
27. Harden K., Tucker-Drob E.M. Individual differences in the development of sensation seeking and impulsivity during adolescence: Further evidence for dual systems model. Developmental Psychology 2011, 47:739-746. 10.1037/a0023279.
28. Harris, K. M., Halpern, C. T., Whitsel, E., Hussey, J., Tabor, J., Entzel, P., & Udry, J. R. (2009). The national longitudinal study of adolescent health: Research design [WWW document]. http://www.cpc.unc.edu/projects/addhealth/design.
29. Hewitt J.K. Editorial policy on candidate gene association and candidate gene-by-environment interaction studies of complex traits. Behavior Genetics 2012, 42(1):1-2.
30. Hur Y.M., Bouchard T.J. The genetic correlation between impulsivity and sensation seeking traits. Behavior Genetics 1997, 27:455-463.
31. Kendler K.S., Bulik C.M., Silberg J., Hettema J.M., Myers J., Prescott C.A. Childhood sexual abuse and adult psychiatric and substance use disorders in women: An epidemiological and cotwin control analysis. Archives of General Psychiatry 2000, 57:953-959. 10.1001/archpsyc.57.10.953.
32. Kluger A.N., Siegfried Z., Ebstein R.P. A meta-analysis of the association between DRD4 polymorphism and novelty seeking. Molecular Psychiatry 2002, 7:712-717.
33. Knorr A.C., Jenkins A.L., Conner B.T. The role of sensation seeking in non-suicidal self-injury. Cognitive Therapy and Research 2013, 37:1276-1284.
34. Krueger R.F., Markon K.E., Patrick C.J., Benning S.D., Kramer M. Linking antisocial behavior, substance use, and personality: An integrative quantitative model of the adult externalizing spectrum. Journal of Abnormal Psychology 2007, 116:645-666.
35. Krueger R.F., Tackett J.L. Personality and psychopathology: Working toward the bigger picture. Journal of Personality Disorders 2003, 17(2):109-128.
36. Maniglio R. The impact of child sexual abuse on health: A systematic review of reviews. Clinical Psychology Review 2009, 29:647-657. 10.1016/j.cpr.2009.08.003.
37. Manolio T.A., Collins F.S., Cox N.J., Goldstein D.B., Hindorff L.A., Hunter D.J., et al. Finding the missing heritability of complex diseases. Nature 2009, 461:747-753.
38. Mendle J., Leve L.D., Van Ryzin M., Natsuaki M.N., Ge X. Associations between early life stress, child maltreatment, and pubertal development among girls in foster care. Journal of Research on Adolescence 2011, 21:871-880.
39. Munafo M.R., Yalcin B., Willis-Owen S.A., Flint J. Association of the dopamine d4 receptor (DRD4) gene and approach-related personality traits: Meta-analysis and new data. Biological Psychiatry 2008, 63:197-206. 10.1016/j.biopsych.2007.04.006.
40. Muthén L.K, Muthén B.O Mplus: Statistical analysis with latent variables. User's guide (Version 7.11) 2013, Muthén & Muthén, Los Angeles, CA.
41. Nelson E.C., Heath A.C., Madden P.F., Cooper L., Dinwiddie S.H., Bucholz K.K., et al. Association between self-reported childhood sexual abuse and adverse psychosocial outcomes: Results from a twin study. Archives of General Psychiatry 2002, 59:139-145. 10.1001/archpsyc.59.2.139.
42. Norbury A., Manohar S., Rogers R.D., Husain M. Dopamine modulates risk-taking as a function of baseline sensation-seeking trait. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 2013, 33:12982-12986. 10.1523/JNEUROSCI.5587-12.2013.
43. Ortin A., Lake A.M., Kleinman M., Gould M.S. Sensation seeking as risk factor for suicidal ideation and suicide attempts in adolescence. Journal of Affective Disorders 2012, 143:214-222. 10.1016/j.jad.2012.05.058.
44. Pluess M., Belsky J. Vantage sensitivity: Individual differences in response to positive experiences. Psychological Bulletin 2013, 139:901-916.
45. Powell J.E., Zietsch B. Predicting sensation seeking from dopamine genes: Use and misuse of genetic prediction. Psychological Science 2011, 22:413-415.
46. Quinn P.D., Harden K.P. Differential changes in impulsivity and sensation seeking and the escalation of substance use from adolescence to early adulthood. Development and Psychopathology 2013, 25:223-239.
47. Robbins T.W., Everitt B.J. Interaction of the dopaminergic system with mechanisms of associative learning and cognition: Implications for drug abuse. Psychological Science 1999, 10:199-202. 10.1111/1467-9280.00134.
48. Romans S.E., Martin J.M., Gendall K., Herbison G.P. Age of menarche: The role of some psychosocial factors. Psychological Medicine 2003, 33:933-939.
49. Schafer J.L., Graham J.W. Missing data: Our view of the state of the art. Psychological Methods 2002, 7:147-177.
50. Settles R.E., Fischer S., Cyders M.A., Combs J.L., Gunn R.L., Smith G.T. Negative urgency: A personality predictor of externalizing behavior characterized by neuroticism, low conscientiousness, and disagreeableness. Journal of Abnormal Psychology 2012, 121:160-172.
51. Simmons J.P., Nelson L.D., Simonsohn U. False-positive psychology: Undisclosed flexibility in data collection and analysis allows presenting anything as significant. Psychological Science 2011, 22:1359-1366. 10.1177/0956797611417632.
52. Smith A.R., Chein J., Steinberg L. Impact of socio-emotional context, brain development, and pubertal maturation on adolescent risk-taking. Hormones and Behavior 2013, 64(2):323-332.
53. Smolen A., Whitsel E.A., Tabor J., Killeya-Jones L.A., Cuthbertson C.C., Hussey J.M., et al. Add Health Wave IV documentation: Candidate genes 2013, Carolina Population Center, University of North Carolina, Chapel Hill, NC, http://www.cpc.unc.edu/projects/addhealth/data/guides/DNA_documentation.pdf.
54. Stautz K., Cooper A. Impulsivity-related personality traits and adolescent alcohol use: A meta-analytic review. Clinical Psychology Review 2013, 33:574-592. 10.1016/j.cpr.2013.03.003.
55. Steinberg L., Albert D., Cauffman E., Banich M., Graham S., Woolard J. Age differences in sensation seeking and impulsivity as indexed by behavior and self-report: Evidence for a dual systems model. Developmental Psychology 2008, 44:1764-1778. 10.1037/a0012955.
56. Stoel R.D., De Geus E.J., Boomsma D.I. Genetic analysis of sensation seeking with an extended twin design. Behavior Genetics 2006, 36:229-237. 10.1007/s10519-005-9028-5.
57. Trickett P.K., Putnam F.W. Impact of child sexual abuse on females: Toward a developmental, psychobiological integration. Psychological Science 1993, 4:81-87.
58. Turner P.K., Runtz M.G., Galambos N.L. Sexual abuse, pubertal timing, and subjective age in adolescent girls: A research note. Journal of Reproductive and Infant Psychology 1999, 17:111-118.
59. Udry J.R. The National Longitudinal Study of Adolescent Health (Add Health), Waves I & II, 1994-1996; Wave III, 2001-2002 [machine-readable data file and documentation] 2003, Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.
60. Van Tol H.M., Wu C.M. Multiple dopamine D4 receptor variants in the human population. Nature 1992, 358:149-152.
61. Whiteside S.P., Lynam D.R. The five factor model and impulsivity: Using structural model of personality to understand impulsivity. Personality and Individual Differences 2001, 30:669-689.
62. Whiteside S.P., Lynam D.R. Understanding the role of impulsivity and externalizing psychopathology in alcohol abuse: Application of the UPPS impulsive behavior scale. Experimental and Clinical Psychopharmacology 2003, 11:210-217.
63. Wise L.A., Palmer J.R., Rothman E.F., Rosenberg L. Childhood abuse and early menarche: Findings from the Black Women's Health Study. American Journal of Public Health 2009, 99:S460-S466.
64. Wonderlich S.A., Crosby R.D., Mitchell J.E., Thompson K.M., Redlin J., Demuth G., et al. Eating disturbance and sexual trauma in childhood and adulthood. International Journal of Eating Disorders 2001, 30:401-412.
65. Zald D.H., Cowan R.L., Riccardi P., Baldwin R.M., Ansari M., Rui L., et al. Midbrain dopamine receptor availability is inversely associated with novelty-seeking traits in humans. Journal of Neuroscience 2008, 28:14372-14378. 10.1523/JNEUROSCI.2423-08.2008.
66. Zuckerman M., Kuhlman D., Joireman J., Teta P., Kraft M. A comparison of three structural models for personality: The big three, the big five, and the alternative five. Journal of Personality and Social Psychology 1993, 65:757-768. 10.1037/0022-3514.65.4.757.