Bacteriophage-loaded nanostructured lipid carrier: Improved pharmacokinetics mediates effective resolution of klebsiella pneumoniae-induced lobar pneumonia

Journal of Infectious Diseases

Volumn 212, Issue 2, 2015, Pages 325-334

  Singla, Saloni ^a   Harjai, Kusum ^a   Katare, Om Prakash ^b   Chhibber, Sanjay ^a  

^a PANJAB UNIVERSITY   (India)

^b PANJAB UNIVERSITY   (India)

Author keywords

K. pneumoniae; liposome entrapped phages; phage therapy; prophylaxis; therapy

Indexed keywords

INTERLEUKIN 10; LIPOSOME; TUMOR NECROSIS FACTOR ALPHA; AUTACOID; NANOMATERIAL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL LOAD; BACTERIAL PNEUMONIA; BACTERIOPHAGE; BIOLOGICAL THERAPY; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HISTOPATHOLOGY; INFECTION PREVENTION; KLEBSIELLA PNEUMONIAE INFECTION; LIPOSOME ENTRAPPED PHAGE THERAPY; LOBAR PNEUMONIA; MOUSE; MOUSE MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; TIME TO TREATMENT; ANIMAL; BAGG ALBINO MOUSE; IMMUNOLOGY; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; LUNG; METABOLISM; MICROBIOLOGY; PHYSIOLOGY; PNEUMONIA, BACTERIAL; VIROLOGY;

ANIMALS; BACTERIOPHAGES; FEMALE; INFLAMMATION MEDIATORS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; LIPOSOMES; LUNG; MICE, INBRED BALB C; NANOSTRUCTURES; PNEUMONIA, BACTERIAL;

EID: 84936884330     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiv029     Document Type: Article

References (29)

1. Doern GV. Trends in antimicrobial susceptibility of bacterial pathogens of respiratory tract. Am J Med 1995; 99: 3S-7.
2. Nishi T, Tsuchiya K. Therapeutic effects of cefotiam and cefazolin on experimental pneumonia caused by Klebsiella pneumoniae DT-S in mice. Antimicrob Agents Chemother 1980; 18: 549-56.
3. Podschun R, Ullmann U. Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin Microbiol Rev 1998; 11: 589-603.
4. Sahm DF, Marsilio MK, Piazza G. Antimicrobial resistance in key bloodstream bacterial isolates: electronic surveillance with the Surveillance Network Database-USA. Clin Infect Dis 1999; 29: 259-63.
5. Jay SJ. Nosocomial pneumonia. Nosocomial Infect 1983; 74: 221-3.
6. Carpenter JL. Klebsiella pulmonary infections: occurrence at one medical center and review. Rev Infect Dis 1990; 12: 672-82.
7. Ko WC, Paterson DL, Sagnimeni AJ, et al. Community-Acquired Klebsiella pneumoniae bacteremia: global differences in clinical patterns. Emerg Infect Dis 2002; 8: 160-6.
8. Lin JC, Siu LK, Fung CP, Yeh KM, Chang FY. Nosocomial liver abscess caused by extended-spectrum beta-lactamase producing Klebsiella pneumoniae. J Clin Microbiol 2007; 45: 266-9.
9. Bull JJ, Levin BR, DeRouin T, Walker N, Bloch CA. Dynamics of success and failure in phage and antibiotic therapy in experimental infections. BMC Microbiol 2002; 2: 35-44.
10. Verma V, Harjai K, Chhibber S. Characterization of a T7-like lytic bacteriophage of Klebsiella pneumoniae B5055: a potential therapeutic agent. Curr Microbiol 2009; 59: 274-81.
11. Held TK, Mielke ME, Chedid M, et al. Granulocyte colony-stimulating factor worsens the outcome of experimental Klebsiella pneumoniae pneumonia through direct interaction with the bacteria. Blood 1998; 91: 2525-35.
12. Yadav V, Sharma S, Harjai K, Mohan H, Chhibber S. Induction & resolution of lobar pneumonia following intranasal instillation with Klebsiella pneumoniae in mice. Indian J Med Res 2003; 118: 47-52.
13. Capparelli R, Parlato M, Borriello G, Salvatore P, Iannelli D. Experimental Phage Therapy against Staphylococcus aureus in Mice. Antimicrob Agents Chemother 2007; 51: 2765-73.
14. Chhibber S, Kaur S, Kumari S. Therapeutic potential of bacteriophage in treating Klebsiella pneumoniae B5055-mediated lobar pneumonia in mice. J Med Microbiol 2008; 57: 1508-13.
15. McVay CS, Velasquez M, Fralick JA. Phage therapy of Pseudomonas aeruginosa infection in a mouse burn wound model. Antimicrob Agents Chemother 2007; 51: 1934-8.
16. Watanabe R, Matsumoto T, Sano G, et al. Efficacy of bacteriophage therapy against gut-derived sepsis caused by Pseudomonas aeruginosa in mice. Antimicrob Agents Chemother 2007; 51: 446-52.
17. Dabrowska K, Switala-Jelen K, Opolski A, Weber-Dabrowska B, Gorski A. Bacteriophage penetration in vertebrates. J Appl Microbiol 2005; 98: 7-13.
18. Carmody LA, Gill JJ, Summer EJ, et al. Efficacy of bacteriophage therapy in a model of Burkholderia cenocepacia pulmonary infection. J Infect Dis 2010; 201: 264-71.
19. Smith HW, Huggins MB. Successful treatment of experimental Escherichia coli infections in mice using phage: its general superiority over antibiotics. J Gen Microbiol 1982; 128: 307-18.
20. Bull JJ, Levin BR, DeRouin T, Walker N, Bloch CA. Dynamics of success and failure in phage and antibiotic therapy in experimental infections. BMC Microbiol 2002; 2: 35.
21. Cerveny KE, DePaola A, Duckworth DH, Gulig PA. Phage therapy of local and systemic disease caused by Vibrio vulnificus in iron-dextran treated mice. Infect Immun 2002; 70: 6251-62.
22. Wong JP, Yang H, Blasetti KL, Schnell G, Conley J, Schofield LN. Liposome delivery of ciprofloxacin against intracellular Francisella tularensis infection. J Control Release 2003; 92: 265-73.
23. Zimecki M, Artym J, Kocieba M, Weber-Dabrowska B, Borysowski J, Górski A. Effects of prophylactic administration of bacteriophages to immunosuppressed mice infected with Staphylococcus aureus. BMC Microbiol 2009; 9: 169.
24. Nonas SA, Finigan JH, Gao L, Garcia JG. Functional genomic insights into acute lung injury: role of ventilators and mechanical stress. Proc Am Thorac Soc 2005; 2: 188-94.
25. Mukhopadhyay S, Hoidal JR, Mukherjee TK. Role of TNFa in pulmonary pathophysiology. Respir Res 2006; 7: 125.
26. Adib-Conquy M, Cavaillon JM. Stress molecules in sepsis and systemic inflammatory response syndrome. FEBS Lett 2007; 581: 3723-33.
27. Debarbieux L, Leduc D, Maura D, et al. Bacteriophages can treat and prevent Pseudomonas aeruginosa lung infections. J Infect Dis 2010; 201: 1096-104.
28. Litzinger DC, Brown JM, Wala I, et al. Fate of cationic liposomes and their complex with oligonucleotide in vivo. Biochim Biophys Acta 1996; 1281: 139-49.
29. Basnet P, Hussain H, Tho I, Skalko-Basnet N. Liposomal delivery system enhances anti-inflammatory properties of curcumin. J Pharm Sci 2012; 101: 598-609.