In vivo evaluation of anionic thiolated polymers as oral delivery systems for efflux pump inhibition

International Journal of Pharmaceutics

Volumn 491, Issue 1-2, 2015, Pages 318-322

  Palmberger, Thomas F ^a   Laffleur, Flavia ^a   Greindl, Melanie ^a   Bernkop Schnürch, Andreas ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Alginate; CMC; In vivo; MRP2; Pectin; Thiolated polymer

Indexed keywords

ALGINIC ACID; BIOPOLYMER; BUFFER; CARBOXYMETHYLCELLULOSE; CYSTEINE CONJUGATE; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2; PECTIN; PENETRATION ENHANCING AGENT; RHODAMINE; SULFORHODAMINE 101; UNCLASSIFIED DRUG; ABC TRANSPORTER; ABCC2 PROTEIN, RAT; CYSTEINE; POLYMER; THIOL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APPARENT PERMEABILITY; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG UPTAKE; IN VITRO STUDY; IN VIVO STUDY; INTESTINE MUCOSA; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; SMALL INTESTINE; TIME TO MAXIMUM PLASMA CONCENTRATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOAVAILABILITY; CHEMISTRY; DIFFUSION CHAMBER; INTESTINE ABSORPTION; METABOLISM; ORAL DRUG ADMINISTRATION; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; ALGINATES; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL AVAILABILITY; CARBOXYMETHYLCELLULOSE SODIUM; CYSTEINE; DIFFUSION CHAMBERS, CULTURE; DRUG DELIVERY SYSTEMS; IN VITRO TECHNIQUES; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; MALE; PECTINS; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; RHODAMINES; SULFHYDRYL COMPOUNDS;

EID: 84936857062     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.06.023     Document Type: Article

References (26)

1. A. Bernkop-Schnürch, and G. Walker Multifunctional matrices for oral peptide delivery Crit. Rev. Ther. Drug Carrier Syst. 18 2001 459 501
2. A. Bernkop-Schnürch, V. Schwarz, and S. Steininger Polymers with thiol groups: a new generation of mucoadhesive polymers? Pharm. Res. 16 1999 876 881
3. M. Buchler, J. Konig, M. Brom, J. Kartenbeck, H. Spring, T. Horie, and D. Keppler cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats J. Biol. Chem. 271 1996 15091 15098
4. B. Carreno-Gomez, and R. Duncan Everted rat intestinal sacs: a new model for the quantitation of P-glycoprotein mediated-efflux of anticancer agents Anticancer Res. 20 2000 3157 3161
5. A.E. Clausen, and A. Bernkop-Schnürch Thiolated carboxymethylcellulose: in vitro evaluation of its permeation enhancing effect on peptide drugs Eur. J. Pharm. Biopharm. 51 2001 25 32
6. T. Demina, I. Grozdova, O. Krylova, A. Zhirnov, V. Istratov, H. Frey, H. Kautz, and N. Melik-Nubarov Relationship between the structure of amphiphilic copolymers and their ability to disturb lipid bilayers Biochemistry 44 2005 4042 4405
7. G.L. Ellman A colorimetric method for determining low concentrations of mercaptans Arch. Biochem. Biophys. 74 1958 443 450
8. F. Föger, T. Schmitz, and A. Bernkop-Schnürch In vivo evaluation of an oral delivery system for P-gp substrates based on thiolated chitosan Biomaterials 27 2006 4250 4255
9. F. Föger, H. Hoyer, K. Kafedjiiski, M. Thaurer, and A. Bernkop-Schürch In vivo comparison of various polymeric and low molecular mass inhibitors of intestinal P-glycoprotein Biomaterials 27 2006 5855 5860
10. V. Grabovac, and A. Bernkop-Schnürch Thiomers: influence of molecular mass and thiol group content of poly(acrylic acid) on efflux pump inhibition Pharm. Res. 2007 under review
11. A.F. Habeeb A sensitive method for localization of disulfide containing peptides in column effluents Anal. Biochem. 56 1973 60 65
12. E.D. Hugger, K.L. Audus, and R.T. Borchardt Effects of poly(ethylene glycol) on efflux transporter activity in Caco-2 cell monolayers J. Pharm. Sci. 91 2002 1980 1990
13. K. Ito, H. Suzuki, T. Horie, and Y. Sugiyama Apical/basolateral surface expression of drug transporters and its role in vectorial drug transport Pharm. Res. 22 2005 1559 1577
14. D. Keppler, and J. Konig Hepatic canalicular membrane 5: expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAT) gene in liver FASEB J. 11 1997 509 516
15. R.B. Kim Drugs as P-glycoprotein substrates, inhibitors, and inducers Drug Metab. Rev. 34 2002 47 54
16. V.M. Leitner, M.K. Marschütz, and A. Bernkop-Schnürch Mucoadhesive and cohesive properties of poly(acrylic acid)-cysteine conjugates with regard to their molecular mass Eur. J. Pharm. Sci. 18 2003 89 96
17. Y.L. Lo, and J.D. Huang Effects of sodium deoxycholate and sodium caprate on the transport of epirubicin in human intestinal epithelial Caco-2 cell layers and everted gut sacs of rats Biochem. Pharmacol. 59 2000 665 672
18. W. Loscher, and H. Potschka Blood-brain barrier active efflux transporters: ATP-binding cassette gene family Neurorx 2 2005 86 98
19. D.S. Miller, R. Masereeuw, J. Henson, and K.J. Karnaky Jr. Excretory transport of xenobiotics by dogfish shark rectal gland tubules Am. J. Physiol. 275 1998 R697 R705
20. D.S. Miller, R. Masereeuw, and K.J. Karnaky Jr. Regulation of MRP2-mediated transport in shark rectal salt gland tubules Am. J. Physiol. Regul. Integr. Comp. Physiol. 282 2002 R774 R781
21. A.D. Mottino, T. Hoffman, L. Jennes, and M. Vore Expression and localization of multidrug resistant protein mrp2 in rat small intestine J. Pharmacol. Exp. Ther. 293 2000 717 723
22. A.H. Schinkel, and J.W. Jonker Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview Adv. Drug Deliv. Rev. 55 2003 3 29
23. M. Takano, R. Yumoto, and T. Murakami Expression and function of efflux drug transporters in the intestine Pharmacol. Ther. 109 2006 137 161
24. X. Tian, X. Yang, K. Wang, and X. Yang The efflux of flavonoids morin, isorhamnetin-3-O-rutinoside and diosmetin-7-O-beta-d-xylopyranosyl-(1-6)-beta-d-glucopyranoside in the human intestinal cell line Caco-2 Pharm. Res. 23 2006 1721 1728
25. M.D. Troutman, and D.R. Thakker Rhodamine 123 requires carrier-mediated influx for its activity as a P-glycoprotein substrate in Caco-2 cells Pharm. Res. 20 2003 1192 1199
26. M. Werle, and M. Hoffer Glutathione and thiolated chitosan inhibit multidrug resistance P-glycoprotein activity in excised small intestine J. Control. Release 111 2006 41 46