Role of the IL-6 gene in the etiopathogenesis of idiopathic scoliosis

Analytical Cellular Pathology

Volumn 2015, Issue , 2015, Pages

  Nikolova, Svetla ^a   Dikova, Milka ^b   Dikov, Dobrin ^b   Djerov, Assen ^b   Dzhebir, Gyulnas ^a   Atanasov, Ventseslav ^a   Savov, Alexey ^a   Kremensky, Ivo ^a  

^a MEDICAL UNIVERSITY OF SOFIA   (Bulgaria)

^b University Specialized Hospital for Active Treatment of Orthopaedics Prof B Boychev   (Bulgaria)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6; IL6 PROTEIN, HUMAN;

ADOLESCENT; ARTICLE; BULGARIAN (PEOPLE); CASE CONTROL STUDY; CHILD; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; GENE AMPLIFICATION; GENETIC POLYMORPHISM; GENETIC SCREENING; GENOTYPE; HUMAN; IDIOPATHIC SCOLIOSIS; MAJOR CLINICAL STUDY; MALE; MOLECULAR PATHOLOGY; PRIORITY JOURNAL; ALLELE; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS; ODDS RATIO; SCOLIOSIS;

ALLELES; CASE-CONTROL STUDIES; CHILD; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTERLEUKIN-6; MALE; ODDS RATIO; SCOLIOSIS;

EID: 84936818523     PISSN: 22107177     EISSN: 22107185     Source Type: Journal    
DOI: 10.1155/2015/621893     Document Type: Article

References (11)

1. J. Scheller, A. Chalaris, D. Schmidt-Arras, and S. Rose-John, "The pro-and anti-inflammatory properties of the cytokine interleukin-6, " Biochimica et Biophysica Acta, vol. 1813, no. 5, pp. 878-888, 2011.
2. M. S. Austin and G. R. Klein, Recent Advances in Orthopedics, Jaypee Brothers Medical Publishers, New Delhi, India, 2014.
3. M. V. Risbud and I. M. Shapiro, "Role of cytokines in intervertebral disc degeneration: pain and disc content, " Nature Reviews Rheumatology, vol. 10, no. 1, pp. 44-56, 2014.
4. J. G. Burke, R.W. G. Watson, D. Conhyea et al., "Humannucleus pulposis can respond to a pro-inflammatory stimulus, " Spine, vol. 28, no. 24, pp. 2685-2693, 2003.
5. M. Mórocz, A. Czibula, Z. B. Grózer et al., "Association study of BMP4, IL6, Leptin, MMP3, and MTNR1B gene promoter polymorphisms and adolescent idiopathic scoliosis, " Spine, vol. 36, no. 2, pp. E123-E130, 2011.
6. M. Hristova, L. Dourmishev, Z. Kamenarska et al., "Role of the promoter polymorphism IL-6-174G/C in dermatomyositis and systemic lupus erythematosus, " BioMed Research International, vol. 2013, Article ID 315365, 5 pages, 2013.
7. L. Aulisa, P. Papaleo, E. Pola et al., "Association between IL-6 and MMP-3 gene polymorphisms and adolescent idiopathic scoliosis: a case-control study, " Spine, vol. 32, no. 24, pp. 2700-2702, 2007.
8. Z. Liu, N. L. S. Tang, X.-B. Cao et al., "Lack of association between the promoter polymorphisms of MMP-3 and IL-6 genes and adolescent idiopathic scoliosis: a case-control study in a Chinese Han population, " Spine, vol. 35, no. 18, pp. 1701-1705, 2010.
9. J. S. Lee, K. T. Suh, and I. S. Eun, "Polymorphismin interleukin-6 gene is associated with bone mineral density in patients with adolescent idiopathic scoliosis, " The Journal of Bone & Joint Surgery Series B, vol. 92, no. 8, pp. 1118-1122, 2010.
10. J. C. Y. Cheng, N. L. S. Tang, H.-Y. Yeung, and N. Miller, "Genetic association of complex traits: using idiopathic scoliosis as an example, " Clinical Orthopaedics and Related Research, no. 462, pp. 38-44, 2007.
11. M. Ivanova, P. Spassova, A. Michailova, and E. Naumova, "Distributions of HLA class I alleles and haplotypes in Bulgarians-contribution to understanding the origin of the population, " Cell & Molecular Biology, vol. 57, pp. 208-215, 2001.