Polymorphism in interleukin-6 gene is associated with bone mineral density in patients with adolescent idiopathic scoliosis

Journal of Bone and Joint Surgery - Series B

Volumn 92, Issue 8, 2010, Pages 1118-1122

  Lee, J S ^a,b   Suh, K T ^a,b   Eun, I S ^a,c  

^a Pusan National University School of Medicine   (South Korea)

^b Pusan National University Yangsan Hospital   (South Korea)

^c Busan Medical Center   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6;

ADOLESCENT; ADOLESCENT DISEASE; ARTICLE; BONE DENSITY; CHILD; CONTROLLED STUDY; ETHNIC GROUP; FEMALE; FEMUR NECK; GENETIC ASSOCIATION; GENOTYPE; HUMAN; IDIOPATHIC SCOLIOSIS; LUMBAR SPINE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE;

ADULT; BONE DENSITY; FEMALE; FEMUR NECK; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTERLEUKIN-6; LUMBAR VERTEBRAE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; SCOLIOSIS;

EID: 77955391093     PISSN: 0301620X     EISSN: None     Source Type: Journal    
DOI: 10.1302/0301-620X.92B8.23676     Document Type: Article

References (38)

1. Ahn UM, Ahn NU, Nallamshetty L, et al. The etiology of adolescent idiopathis scoliosis. Am J Orthop 2002;31:387-95.
2. Ford DM, Bagnall KM, Clements CA, McFadden KD. Muscle spindles in the paraspinal musculature of patients with adolescent idiopathic scoliosis. Spine 1988;13:461-5.
3. Ford DM, Bagnall KM, McFadden KD, Greenhill BJ, Raso VJ. Paraspinal muscle imbalance in adolescent idiopathic scoliosis. Spine 1984;9:373-6.
4. Kindsfater K, Lowe T, Lawellin D, Weinstein D, Akmakjian J. Levels of platelet calmodulin for the prediction of progression and severity of adolescent idiopathic scoliosis. J Bone Joint Surg [Am] 1994;76-A:1186-92. (Pubitemid 24282193)
5. Machida M, Dubousset J, Imamura Y, et al. Pathogenesis of idiopathic scoliosis: SEPs in chicken with experimentally induced scoliosis and in patients with idiopathic scoliosis. J Pediatr Orthop 1994;14:329-35. (Pubitemid 24129828)
6. McCarrey JR, Abbott UK, Benson DR, Riggins RS. Genetics of scoliosis in chickens. J Hered 1981;72:6-10.
7. Stiwell DL Jr. Structural deformities of vertebrae: bone adaptation and modeling in experimental scoliosis and kyphosis. J Bone Joint Surg [Am] 1962;44-A:611-34.
8. Suh KT, Lee SS, Kim SJ, Kim YK, Lee JS. Pineal gland metabolism in patients with adolescent idiopathic scoliosis. J Bone Joint Surg [Br] 2007;89-B:66-71. (Pubitemid 46218415)
9. Wand ED, Drummond DS, Dormans JP, et al. Scoliosis in patients treated with growth hormone. J Pediatr Orthop 1997;17:708-11.
10. Burner WL 3rd, Badger VM, Sherman FC. Osteoporosis and acquired back deformities. J Pediatr Orthop 1982;2:383-5.
11. Singh M, Magrath AR, Maini PS. Changes in trabecular pattern of the upper end of the femur as an index of osteoporosis. J Bone Joint Surg [Am] 1970;52-A:457-67.
12. Cheng JC, Guo X, Sher AH. Persistent osteopenia in adolescent idiopathic scoliosis: a longitudinal study. Spine 1999;24:1218-22. (Pubitemid 29279465)
13. Cheng JC, Qin L, Cheung CS, et al. Generalized low areal and volumetric bone mineral density in adolescent idiopathic scoliosis. J Bone Miner Res 2000;15:1587-95. (Pubitemid 30484529)
14. Cook SD, Harding AF, Morgan EL, et al. Trabecular bone mineral density in idiopathic scoliosis. J Pediatr Orthop 1987;7:168-74.
15. Suh KT, Lee SS, Hwang SH, Kim SJ, Lee JS. Elevated soluble receptor activator of nuclear factor-kappaB ligand and reduced bone mineral density in patients with adolescent idiopathic scoliosis. Eur Spine J 2007;16:1563-9.
16. Thomas KA, Cook SD, Skalley TC, et al. Lumbar spine and femoral neck bone mineral density in idiopathic scoliosis: a follow-up study. J Pediatr Orthop 1992;12:235-40.
17. Cheng JC, Tang SP, Guo X, Chan CW, Qin L. Osteopenia in adolescent idiopathic scoliosis: a histomorphometric study. Spine 2001;26:E19-23.
18. Fang Y, van Meurs JB, Bergink AP, et al. Cdx-2 polymorphism in the promoter region of the human vitamin D receptor gene determines susceptibility to fracture in the elderly. J Bone Miner Res 2003;18:1632-41. (Pubitemid 37022921)
19. Ioannidis JP, Ralston SH, Bennett ST, et al; GENOMOS Study. Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes. JAMA 2004;292:2105-14.
20. Murray RE, McGuigan F, Grant SF, Reid DM, Ralston SH. Polymorphisms of the interleukin-6 gene are associated with bone mineral density. Bone 1997;21:89-92. (Pubitemid 27341744)
21. Uitterlinden AG, Burger H, Huang Q, et al. Relation of alleles of the collagen type lalpha1 gene to bone density and the risk of osteoporotic fractures in postmenopausal women. N Engl J Med 1998;338:1016-21. (Pubitemid 28180402)
22. Uitterlinden AG, Pols HA, Burger H, et al. A large-scale population-based study of the association of vitamin D receptor gene polymorphisms with bone mineral density. J Bone Miner Res 1996;11:1241-8. (Pubitemid 26282524)
23. van Meurs JB, Schuit SC, Weel AE, et al. Association of 5' estrogen receptor alpha gene polymorphisms with bone mineral density, vertebral bone area and fracture risk. Hum Mol Genet 2003;12:1745-54.
24. Roodman GD. Interleukin-6: an osteotropic factor? J Bone Miner Res 1992;7:475-8.
25. Ralston SH. Analysis of gene expression in human bone biopsies by polymerase chain reaction:evidence for enhanced cytokine expression in postmenopausal osteoporosis. J Bone Miner Res 1994;9:883-90.
26. Ota N, Nakajima T, Nakazawa I, et al. A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density. J Hum Genet 2001;46:267-72. (Pubitemid 32410678)
27. Chung HW, Seo JS, Hur SE, et al. Association of interleukin-6 promoter variant with bone mineral density in pre-menopausal women. J Hum Genet 2003;48:243-8.
28. Huang QY, Shen H, Deng HY, et al. Linkage and association of the CA repeat polymorphism of the IL6 gene, obeisty-related phenotypes, and bone mineral density (BMD) in two independent Caucasian populations. J Hum Genet 2003;48:430-7. (Pubitemid 37221559)
29. Bustamante M, Nogués X, Mellibovsky L, et al. Polymorphisms in the interleukin-6 receptor gene are associated with bone mineral density and body mass index in Spanish postmenopausal women. Eur J Endocrinol 2007;157:677-84. (Pubitemid 350187386)
30. Moffett SP, Zmuda JM, Cauley JA, et al; SOF Research Group. Association of the G-174C variant in the interleukin-6 promoter region with bone loss and fracture risk in older women. J Bone Miner Res 2004;19:1612-18.
31. Ferrari SL, Garnero P, Emond S, et al. A functional polymorphic variant in the interleukin- 6 gene promoter associated with low bone resorption in postmenopausal women. Arthritis Rheum 2001;44:196-201. (Pubitemid 32113135)
32. Cheng JC, Guo X. Osteopenia in adolescent idiopathic scoliosis: a primary problem or secondary to the spinal deformity? Spine 1997;22:1716-21. (Pubitemid 28076403)
33. Eun IS, Park WW, Sch KT, Kim JL, Lee JS. Association between osteoprotegerin gene polymorphisim and bone mineral density in patients with adolescent idiopathic scoliosis. Eur Spine J 2009;18:1936-40.
34. Fedetz M, Matesanz F, Pascual M, et al. The -174/-597 promoter polymorphisms in the interleukin-6 gene are not associated with susceptibility to multiple sclerosis. J Neurol Sci 2001;190:69-72. (Pubitemid 33713024)
35. Helmy N, Maly FE, Bestmann L. Detection of the single-base substitution -174 G --> C in the interleukin-6 gene by real-time polymerase chain reaction: comment on the article by Moos et al. Arthritis Rheum 2001;44:2213-14.
36. Zhai R, Liu G, Yang C, et al. The G to C polymorphism at -174 of the interleukin-6 gene is rare in a Southern Chinese population. Pharmacogenetics 2001;11:699-701. (Pubitemid 33078239)
37. Fishman D, Faulds G, Jeffrey R, et al. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 1998;102:1369-76. (Pubitemid 28467565)
38. Manolagas SC. The role of IL-6 type cytokines and their receptors in bone. Ann N Y Acad Sci 1998;840:194-204. (Pubitemid 28302050)