Structure guided chemical modifications of propylthiouracil reveal novel small molecule inhibitors of cytochrome b5 reductase 3 that increase nitric oxide bioavailability

Journal of Biological Chemistry

Volumn 290, Issue 27, 2015, Pages 16861-16872

  Rahaman, Md Mizanur ^a   Reinders, Fabio G ^a   Koes, David ^a   Nguyen, Anh T ^a   Mutchler, Stephanie M ^a   Sparacino Watkins, Courtney ^a   Alvarez, Roger A ^a   Miller, Megan P ^a   Cheng, Dongmei ^a   Chen, Bill B ^a   Jackson, Edwin K ^a   Camacho, Carlos J ^a   Straub, Adam C ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; MOLECULES; NITRIC OXIDE;

CYTOCHROME B5; DRUG DEVELOPMENT; SMALL MOLECULE INHIBITOR; VASCULAR FUNCTIONS;

CHEMICAL MODIFICATION;

CYTOCHROME B5 REDUCTASE; CYTOCHROME B5 REDUCTASE 3; NITRIC OXIDE; OXIDOREDUCTASE INHIBITOR; PROPYLTHIOURACIL; THIOURACIL DERIVATIVE; UNCLASSIFIED DRUG; ZINC 05626394; ZINC 39395747; ENZYME INHIBITOR;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOAVAILABILITY; CELL CULTURE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SCREENING; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; HEART RATE; HUMAN; HUMAN CELL; IC50; IN VIVO STUDY; KIDNEY BLOOD FLOW; KIDNEY CELL; KIDNEY VASCULAR RESISTANCE; MEAN ARTERIAL PRESSURE; MOLECULAR DOCKING; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; RENAL VASCULAR CELL; STRUCTURE ACTIVITY RELATION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; GENETICS; METABOLISM;

ANIMALS; CYTOCHROME-B(5) REDUCTASE; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; MOLECULAR STRUCTURE; NITRIC OXIDE; PROPYLTHIOURACIL; RATS;

EID: 84936816931     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.629964     Document Type: Article

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