Oral administration of escin inhibits acute inflammation and reduces intestinal mucosal injury in animal models

Evidence-based Complementary and Alternative Medicine

Volumn 2015, Issue , 2015, Pages

  Li, Minmin ^a   Lu, Chengwen ^a   Zhang, Leiming ^a   Zhang, Jianqiao ^a   Du, Yuan ^a   Duan, Sijin ^a   Wang, Tian ^a   Fu, Fenghua ^a  

^a YANTAI UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; AMINE OXIDASE (COPPER CONTAINING); ANTIINFLAMMATORY AGENT; CLAUDIN 5; CYCLOOXYGENASE 2; DEXAMETHASONE; DEXAMETHASONE SODIUM PHOSPHATE; ENDOTOXIN; ESCIN; PROSTAGLANDIN E2;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARRAGEENAN-INDUCED PAW EDEMA; CONTROLLED STUDY; ENTERITIS; GRANULOCYTE; INTESTINE MUCOSA; LIVER INJURY; LOW DRUG DOSE; MALE; MOUSE; NEUTROPHIL COUNT; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; RAT; SEPSIS; UPREGULATION;

EID: 84936805354     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2015/503617     Document Type: Article

References (30)

1. T. Rhen and J. A. Cidlowski, Antiinflammatory action of glucocorticoids-new mechanisms for old drugs. The New England Journal ofMedicine. 353, no. 16, pp. 1711-1723, 2005
2. G. Ruoff, Rheumatoid arthritis: early treatment with corticosteroids and nonsteroidal anti-inflammatory drugs. Journal of Family Practice. 63, no. 2, pp. S27-S30, 2014
3. A. E. Coutinho and K. E. Chapman, The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments andmechanistic insights, Molecular and Cellular Endocrinology. 335, no. 1, pp. 2-13, 2011
4. G. Mazziotti, E. Canalis, and A. Giustina, Drug-induced osteoporosis: mechanisms and clinical implications. American Journal of Medicine. 123, no. 10, pp. 877-884, 2010
5. S. Harirforoosh, W. Asghar, and F. Jamali, Adverse effects of nonsteroidal antiinflammatory drugs: an update of gastrointestinal, cardiovascular and renal complications. Journal of Pharmacy and Pharmaceutical Sciences. 16, no. 5, pp. 821-847, 2013
6. F. Fu, Y. Hou, W. Jiang, R.Wang, and K. Liu, Escin: inhibiting inflammation and promoting gastrointestinal transit to attenuate formation of postoperative adhesions. World Journal of Surgery. 29, no. 12, pp. 1614-1620, 2005
7. N. Jiang, W. Xin, T.Wang, et al., Protective effect of aescin from the seeds of Aesculus hippocastanum on liver injury induced by endotoxin in mice. Phytomedicine. 18, no. 14, pp. 1276-1284, 2011
8. W. Xin, L. Zhang, H. Fan, N. Jiang, T. Wang, and F. Fu, Escin attenuates acute lung injury induced by endotoxin in mice. European Journal of Pharmaceutical Sciences. 42, no. 1-2, pp. 73-80, 2011
9. L. Zhang, F. Fu, X. Zhang, M. Zhu, T. Wang, and H. Fan, Escin attenuates cognitive deficits and hippocampal injury after transient global cerebral ischemia in mice via regulating certain inflammatory genes. Neurochemistry International. 57, no. 2, pp. 119-127, 2010
10. Z. P. Liu, P.Hu, C. H. Li, X. L.Wang, and X.Xiao, Therapeutic value of aescine in traumatic acute lung injury. Journal of Traumatic Surgery. 15, no. 6, pp. 497-499, 2013
11. Y. Wang, W. G. Zhang, L. Jiang, and Q. B. Wang, Clinical efficacy analysis of sodium ascinate adjuvant in treatment of tibial plateau fracture. Chinese Journal of Biochemical Pharmaceutics. 34, no. 2, pp. 102-104, 2014
12. X.Y.Xie, Q.F.Li, H. X. Zhang, and L.Wang, Literature analysis of 505 cases of adverse drug reactions induced by sodium aescinate injection. Chinese Journal of Pharmacovigilance. 11, no. 4, pp. 229-234, 2014
13. N. Chen, The related factor analysis of 20 phlebitis cases induced by sedium aescinate for injection. Chinese Journal of Pharmacovigilance. 6, no. 10, pp. 595-597, 2009
14. Z. W. Li, H. Huang, Y. Qin, et al., Preparation of sodium aescinate micro-emulsion for injection. Journal of Sichuan University (Medical Science Edition). 45, no. 1, pp. 147-151, 2014
15. H. B. Nguyen and D. Smith, Sepsis in the 21st century: recent definitions and therapeutic advances. American Journal of Emergency Medicine. 25, no. 5, pp. 564-571, 2007
16. S.N. Stehr and K. Reinhart, Sepsis as a global health problem-whywe need a global sepsis alliance. Shock. 39, supplement 1, pp. 3-4, 2013
17. H. Matsuda, Y. Li, and M. Yoshikawa, Effects of escins Ia, Ib, IIa, and IIb fromhorse chestnuts on gastrointestinal transit and ileus in mice. Bioorganic andMedicinal Chemistry. 7, no. 8, pp. 1737-1741, 1999
18. W. Y. Xin, L. M. Zhang, T. Wang, and F. H. Fu, The protective effect of semen aesculi extracts on gastric ulcer induced by aspirin. Chinese Journal of Pharmacovigilance. 7, no. 6, pp. 321-323, 2010
19. F.G. Soriano, C. B. Lorigados, P. Pacher, and C. Szabó, Effects of a potent peroxynitrite decomposition catalyst inmurinemodels of endotoxemia and sepsis. Shock. 35, no. 6, pp. 560-566, 2011
20. C. Debprasad, M. Hemanta, B. Paromita, et al., Inhibition of NO2, PGE2, TNF-β, and iNOS EXpression by Shorea robusta L.: an ethnomedicine used for anti-inflammatory and analgesic activity. Evidence-Based Complementary and Alternative Medicine. 2012, Article ID 254849, 14 pages, 2012
21. A. C. Piccinelli, D. Figueiredo de Santana Aquino, P. N.Morato, et al., Anti-inflammatory and antihyperalgesic activities of ethanolic extract and fruticulin a from salvia lachnostachys leaves in mice. Evidence-Based Complementary and Alternative Medicine. 2014, Article ID 835914, 8 pages, 2014
22. X. Niu, W. Xing, W. Li, T. Fan, H. Hu, and Y. Li, Isofraxidin exhibited anti-inflammatory effects in vivo and inhibited TNF-β production in LPS-inducedmouse peritoneal macrophages in vitro via the MAPK pathway. International Immunopharmacology. 14, no. 2, pp. 164-171, 2012
23. N. Yang, W. Zhang, and X.-M. Shi, Glucocorticoid-induced leucine zipper (GILZ) mediates glucocorticoid action and inhibits inflammatory cytokine-induced COX-2 expression. Journal of Cellular Biochemistry. 103, no. 6, pp. 1760-1771, 2008
24. W. Xin, L. Zhang, F. Sun, et al., Escin exerts synergistic antiinflammatory effects with low doses of glucocorticoids in vivo and in vitro. Phytomedicine. 18, no. 4, pp. 272-277, 2011
25. N. Nesseler, Y. Launey, C.Aninat, F. Morel, Y. Mallédant, and P. Seguin, Clinical review: the liver in sepsis. Critical Care. 16, no. 5, article 235, 2012
26. Z. Hossain and T. Hirata, Molecular mechanism of intestinal permeability: interaction at tight junctions. Molecular BioSystems. 4, no. 12, pp. 1181-1185, 2008
27. J. Gavard and S. J.Gutkind, VE-cadherin and claudin-5: it takes two to tango. Nature Cell Biology. 10, no. 8, pp. 883-885, 2008
28. C. Greenhill, IBD: glucocorticoids revealed to augment intestinal epithelial barrier function, Nature ReviewsGastroenterology and Hepatology. 11, no. 2, p. 75, 2014
29. A. Fischer, M. Gluth, F. Weege, et al., Glucocorticoids regulate barrier function and claudin expression in intestinal epithelial cells via MKP-1. The American Journal of Physiology-Gastrointestinal and Liver Physiology. 306, no. 3, pp. G218-G228, 2014
30. E. Seweryn, M. Gleńsk, K. ͆roda-Pomianek, I. Ceremuga, M. Wlodarczyk, and A. Gamian, Cytotoxic effects of four aescin types on human colon adenocarcinoma cell lines. Natural Product Communications. 9, no. 3, pp. 387-390, 2014