Formation, accumulation, and hydrolysis of endogenous and exogenous formaldehyde-induced DNA damage

Toxicological Sciences

Volumn 146, Issue 1, 2015, Pages 170-182

  Yu, Rui ^a   Lai, Yongquan ^a   Hartwell, Hadley J ^a   Moeller, Benjamin C ^b   Doyle Eisele, Melanie ^b   Kracko, Dean ^b   Bodnar, Wanda M ^a   Starr, Thomas B ^a,c   Swenberg, James A ^a  

^a University of North Carolina at Chapel Hill   (United States)

^b LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

^c TBS Associates   (United States)

Author keywords

Accumulation; Artifacts; Distribution; DNA monoadducts; DNA protein crosslinks; Endogenous; Exogenous; Formaldehyde; Half life; Nano liquid chromatography tandem mass spectrometry; Steady state

Indexed keywords

BIOLOGICAL MARKER; FORMALDEHYDE; N2 HYDROXYMETHYL DEOXYGUANOSINE; UNCLASSIFIED DRUG; DNA;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEGRADATION; DNA ADDUCT; DNA DAMAGE; DNA PROTEIN CROSSLINK; EXPOSURE; HALF LIFE TIME; HYDROLYSIS; MACACA FASCICULARIS; MALE; MONKEY MODEL; NONHUMAN; NOSE MUCOSA; PROTEIN DNA BINDING; RAT; STATISTICAL ANALYSIS; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANIMAL; DRUG EFFECTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN;

PRIMATES; RATTUS; RODENTIA;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA; DNA DAMAGE; FORMALDEHYDE; HUMANS; HYDROLYSIS; RATS; TANDEM MASS SPECTROMETRY;

EID: 84936770976     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfv079     Document Type: Article

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