메뉴 건너뛰기




Volumn 50, Issue 3, 2014, Pages 971-978

Heme Oxygenase-2 Suppress TNF-α and IL6 Expression via TLR4/MyD88-Dependent Signaling Pathway in Mouse Cerebral Vascular Endothelial Cells

Author keywords

Cerebral vascular endothelial cells; CLI 095; Heme oxygenase 2; Interleukin 6; Tumor necrosis factor

Indexed keywords

ETHYL 6-(N-(2-CHLORO-4-FLUOROPHENYL)SULFAMOYL)CYCLOHEX-1-ENE-1-CARBOXYLATE; HEME OXYGENASE; HEME OXYGENASE-2; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; SMALL INTERFERING RNA; SULFONAMIDE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

EID: 84936745407     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-014-8693-x     Document Type: Article
Times cited : (21)

References (22)
  • 1
    • 0033992256 scopus 로고    scopus 로고
    • Developmentally regulated expression of two transcripts for heme oxygenase-2 with a first exon unique to rat testis: Control by corticosterone of the oxygenase protein expression
    • COI: 1:CAS:528:DyaK1MXotVGlt7Y%3D, PID: 10607912
    • Liu N, Wang X, McCoubrey WK, Maines MD (2000) Developmentally regulated expression of two transcripts for heme oxygenase-2 with a first exon unique to rat testis: Control by corticosterone of the oxygenase protein expression. Gene 241:175–183
    • (2000) Gene , vol.241 , pp. 175-183
    • Liu, N.1    Wang, X.2    McCoubrey, W.K.3    Maines, M.D.4
  • 3
    • 0041357192 scopus 로고    scopus 로고
    • Endogenous heme oxygenase prevents impairment of cerebral vascular functions caused by seizures
    • COI: 1:CAS:528:DC%2BD3sXnsVGnu7g%3D, PID: 12915392
    • Carratu P, Pourcyrous M, Fedinec A, Leffler CW, Parfenova H (2003) Endogenous heme oxygenase prevents impairment of cerebral vascular functions caused by seizures. Am J Physiol Heart Circ Physiol 285:H1148–H1157
    • (2003) Am J Physiol Heart Circ Physiol , vol.285 , pp. H1148-H1157
    • Carratu, P.1    Pourcyrous, M.2    Fedinec, A.3    Leffler, C.W.4    Parfenova, H.5
  • 4
    • 10344219952 scopus 로고    scopus 로고
    • Distinct protective mechanisms of HO-1 and HO-2 against hydroperoxideinduced cytotoxicity
    • COI: 1:CAS:528:DC%2BD2cXhtVKrtL7I, PID: 15589375
    • Kim YS, Zhuang H, Koehler RC, Dore S (2005) Distinct protective mechanisms of HO-1 and HO-2 against hydroperoxideinduced cytotoxicity. Free Radic Biol Med 38:85–92
    • (2005) Free Radic Biol Med , vol.38 , pp. 85-92
    • Kim, Y.S.1    Zhuang, H.2    Koehler, R.C.3    Dore, S.4
  • 5
    • 0038206550 scopus 로고    scopus 로고
    • Heme oxygenase-2 protects against lipid peroxidation-mediated cell loss and impaired motor recovery after traumatic brain injury
    • COI: 1:CAS:528:DC%2BD3sXjslGnurs%3D, PID: 12736340
    • Chang EF, Wong RJ, Vreman HJ, Igarashi T, Galo E, Sharp FR, Stevenson DK, Noble-Haeusslein LJ (2003) Heme oxygenase-2 protects against lipid peroxidation-mediated cell loss and impaired motor recovery after traumatic brain injury. J Neurosci 23:3689–3696
    • (2003) J Neurosci , vol.23 , pp. 3689-3696
    • Chang, E.F.1    Wong, R.J.2    Vreman, H.J.3    Igarashi, T.4    Galo, E.5    Sharp, F.R.6    Stevenson, D.K.7    Noble-Haeusslein, L.J.8
  • 6
    • 79955612795 scopus 로고    scopus 로고
    • Targeted suppression of HO-2 gene expression impairs the innate anti-inflammatory and repair responses of the cornea to injury
    • COI: 1:CAS:528:DC%2BC3MXmtVKrt70%3D, PID: 21552471
    • Bellner L, Patil KA, Castellano K, Halilovic A, Dunn MW, Schwartzman ML (2011) Targeted suppression of HO-2 gene expression impairs the innate anti-inflammatory and repair responses of the cornea to injury. Mol Vis 17:1144–1152
    • (2011) Mol Vis , vol.17 , pp. 1144-1152
    • Bellner, L.1    Patil, K.A.2    Castellano, K.3    Halilovic, A.4    Dunn, M.W.5    Schwartzman, M.L.6
  • 7
    • 77950343791 scopus 로고    scopus 로고
    • Pattern recognition receptors and inflammation
    • COI: 1:CAS:528:DC%2BC3cXlsVSgu74%3D, PID: 20303872
    • Takeuchi O, Akira S (2010) Pattern recognition receptors and inflammation. Cell 140:805–820
    • (2010) Cell , vol.140 , pp. 805-820
    • Takeuchi, O.1    Akira, S.2
  • 8
    • 45849105153 scopus 로고    scopus 로고
    • Toll-like receptor 4-dependent upregulation of cytokines in a trans-genic mouse model of Alzheimer’s disease
    • PID: 18510752
    • Jin JJ, Kim HD, Maxwell JA, Li L, Fukuchi K (2008) Toll-like receptor 4-dependent upregulation of cytokines in a trans-genic mouse model of Alzheimer’s disease. J Neuroinflammation 5:23
    • (2008) J Neuroinflammation , vol.5 , pp. 23
    • Jin, J.J.1    Kim, H.D.2    Maxwell, J.A.3    Li, L.4    Fukuchi, K.5
  • 9
    • 67849102209 scopus 로고    scopus 로고
    • Toll-like receptors in the CNS: Implications for neurodegeneration and repair
    • PID: 19660653
    • van Noort JM, Bsibsi M (2009) Toll-like receptors in the CNS: Implications for neurodegeneration and repair. Prog Brain Res 175:139–148
    • (2009) Prog Brain Res , vol.175 , pp. 139-148
    • van Noort, J.M.1    Bsibsi, M.2
  • 11
    • 84885607449 scopus 로고    scopus 로고
    • Melatonin alleviates secondary brain damage and neurobehavioral dysfunction after experimental subarachnoid hemorrhage: Possible involvement of TLR4-mediated inflammatory pathway
    • COI: 1:CAS:528:DC%2BC3sXhs1SlsrvF, PID: 24007200
    • Wang Z, Wu L, You W, Ji C, Chen G (2013) Melatonin alleviates secondary brain damage and neurobehavioral dysfunction after experimental subarachnoid hemorrhage: Possible involvement of TLR4-mediated inflammatory pathway. J Pineal Res 55:399–408
    • (2013) J Pineal Res , vol.55 , pp. 399-408
    • Wang, Z.1    Wu, L.2    You, W.3    Ji, C.4    Chen, G.5
  • 12
    • 33645882947 scopus 로고    scopus 로고
    • Lovastatin reduces apoptosis and downregulates the CD40 expression induced by TNF-alpha in cerebral vascular endothelial cells
    • COI: 1:CAS:528:DC%2BD28Xms12lsbY%3D, PID: 16472124
    • Lin R, Liu J, Peng N, Gan W, Wang W, Han C, Ding C (2006) Lovastatin reduces apoptosis and downregulates the CD40 expression induced by TNF-alpha in cerebral vascular endothelial cells. Curr Neurovasc Res 3:41–47
    • (2006) Curr Neurovasc Res , vol.3 , pp. 41-47
    • Lin, R.1    Liu, J.2    Peng, N.3    Gan, W.4    Wang, W.5    Han, C.6    Ding, C.7
  • 13
    • 0034703359 scopus 로고    scopus 로고
    • Chemical hypoxia-ischemia induces apoptosis in cerebromicrovascular endothelial cells
    • COI: 1:CAS:528:DC%2BD3cXmtlGku7c%3D, PID: 10986325
    • Zhang J, Tan Z, Tran ND (2000) Chemical hypoxia-ischemia induces apoptosis in cerebromicrovascular endothelial cells. Brain Res 877:134–140
    • (2000) Brain Res , vol.877 , pp. 134-140
    • Zhang, J.1    Tan, Z.2    Tran, N.D.3
  • 14
    • 33751094332 scopus 로고    scopus 로고
    • HO-2 provides endogenous protection against oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cells
    • COI: 1:CAS:528:DC%2BD28Xht1Gns7rL, PID: 16822952
    • Basuroy S, Bhattacharya S, Tcheranova D, Qu Y, Regan RF, Leffler CW, Parfenova H (2006) HO-2 provides endogenous protection against oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cells. Am J Physiol Cell Physiol 291(5):C897–C908
    • (2006) Am J Physiol Cell Physiol , vol.291 , Issue.5 , pp. C897-C908
    • Basuroy, S.1    Bhattacharya, S.2    Tcheranova, D.3    Qu, Y.4    Regan, R.F.5    Leffler, C.W.6    Parfenova, H.7
  • 15
    • 33645097021 scopus 로고    scopus 로고
    • A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling
    • COI: 1:CAS:528:DC%2BD28XjtlKntLs%3D, PID: 16373689
    • Ii M, Matsunaga N, Hazeki K, Nakamura K, Takashima K, Seya T, Hazeki O, Kitazaki T, Iizawa Y (2006) A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling. Mol Pharmacol 69:1288–1295
    • (2006) Mol Pharmacol , vol.69 , pp. 1288-1295
    • Ii, M.1    Matsunaga, N.2    Hazeki, K.3    Nakamura, K.4    Takashima, K.5    Seya, T.6    Hazeki, O.7    Kitazaki, T.8    Iizawa, Y.9
  • 16
    • 33646436473 scopus 로고    scopus 로고
    • Glutamate induces oxidative stress and apoptosis in cerebral vascular endothelial cells: Contributions of HO-1 and HO-2 to cytoprotection
    • COI: 1:CAS:528:DC%2BD28XkvFKmtbs%3D, PID: 16371440
    • Parfenova H, Basuroy S, Bhattacharya S, Tcheranova D, Qu Y, Regan RF, Leffler CW (2006) Glutamate induces oxidative stress and apoptosis in cerebral vascular endothelial cells: Contributions of HO-1 and HO-2 to cytoprotection. Am J Physiol Cell Physiol 290:C1399–C1410
    • (2006) Am J Physiol Cell Physiol , vol.290 , pp. C1399-C1410
    • Parfenova, H.1    Basuroy, S.2    Bhattacharya, S.3    Tcheranova, D.4    Qu, Y.5    Regan, R.F.6    Leffler, C.W.7
  • 17
    • 33645817522 scopus 로고    scopus 로고
    • Carbon monoxide and hydrogen sulfide: Gaseous messengers in cerebrovascular circulation
    • COI: 1:CAS:528:DC%2BD28Xis1Sns70%3D, PID: 16467393
    • Leffler CW, Parfenova H, Jaggar JH, Wang R (2006) Carbon monoxide and hydrogen sulfide: Gaseous messengers in cerebrovascular circulation. J Appl Physiol 100:1065–1076
    • (2006) J Appl Physiol , vol.100 , pp. 1065-1076
    • Leffler, C.W.1    Parfenova, H.2    Jaggar, J.H.3    Wang, R.4
  • 18
    • 0032522255 scopus 로고    scopus 로고
    • Blirubin is an effective antioxidant of peroxynitrite-mediated protein oxidation in human blood plasma
    • COI: 1:CAS:528:DyaK1cXislahs78%3D, PID: 9587403
    • Minetti M, Mallozzi C, Di Stasi AM, Pietraforte D (1998) Blirubin is an effective antioxidant of peroxynitrite-mediated protein oxidation in human blood plasma. Arch Biochem Biophys 352:165–174
    • (1998) Arch Biochem Biophys , vol.352 , pp. 165-174
    • Minetti, M.1    Mallozzi, C.2    Di Stasi, A.M.3    Pietraforte, D.4
  • 19
    • 84869490391 scopus 로고    scopus 로고
    • The toll-like receptor 4-mediated signaling pathway is activated following optic nerve injury in mice
    • COI: 1:CAS:528:DC%2BC38Xhs1Cjs7fP
    • Zheng Z, Yuan R, Song M, Huo Y, Liu W, Cai X, Zou H, Chen C, Ye J (2012) The toll-like receptor 4-mediated signaling pathway is activated following optic nerve injury in mice. Brain Res Dec 1489:90–97
    • (2012) Brain Res Dec , vol.1489 , pp. 90-97
    • Zheng, Z.1    Yuan, R.2    Song, M.3    Huo, Y.4    Liu, W.5    Cai, X.6    Zou, H.7    Chen, C.8    Ye, J.9
  • 20
    • 33646039529 scopus 로고    scopus 로고
    • Cutting edge: Diminished T cell TLR expression and function modulates the immune response in human filarial infection
    • COI: 1:CAS:528:DC%2BD28Xis1ertL8%3D, PID: 16547219
    • Babu S, Blauvelt CP, Kumaraswami V, Nutman TB (2006) Cutting edge: Diminished T cell TLR expression and function modulates the immune response in human filarial infection. J Immunol 176:3885–3889
    • (2006) J Immunol , vol.176 , pp. 3885-3889
    • Babu, S.1    Blauvelt, C.P.2    Kumaraswami, V.3    Nutman, T.B.4
  • 21
    • 33947668943 scopus 로고    scopus 로고
    • Viral recognition by Toll-like receptors
    • COI: 1:CAS:528:DC%2BD2sXjslGrsb4%3D, PID: 17336545
    • Barton GM (2007) Viral recognition by Toll-like receptors. Semin Immunol 19:33–40
    • (2007) Semin Immunol , vol.19 , pp. 33-40
    • Barton, G.M.1
  • 22
    • 41149131096 scopus 로고    scopus 로고
    • TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain
    • Kawamoto T, Ii M, Kitazaki T, Iizawa Y, Kimura H (2008) TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain. Eur J Pharmacol 58:40–48
    • (2008) Eur J Pharmacol , vol.58 , pp. 40-48
    • Kawamoto, T.1    Ii, M.2    Kitazaki, T.3    Iizawa, Y.4    Kimura, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.