Protopanaxtriol protects against 3-nitropropionic acid-induced oxidative stress in a rat model of Huntington's disease

Acta Pharmacologica Sinica

Volumn 36, Issue 3, 2015, Pages 311-322

  Gao, Yan ^a   Chu, Shi Feng ^a   Li, Jian Ping ^a   Zhang, Zhao ^a   Yan, Jia Qing ^a   Wen, Zhi Lin ^b   Xia, Cong Yuan ^a   Mou, Zheng ^a   Wang, Zhen Zhen ^a   He, Wen Bin ^a,b   Guo, Xiao Feng ^b   Wei, Gui Ning ^c   Chen, Nai Hong ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

^b SHANXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^c Guangxi Institute of Chinese Medicine and Pharmaceutical Science   (China)

Author keywords

3 nitropropionic acid; Hsp70; Huntington's disease; N acetyl cysteine; Nimodipine; Nrf2 pathway; Panax ginseng; Protopanaxtriol; ROS; Striatum

Indexed keywords

3 NITROPROPIONIC ACID; ACETYLCYSTEINE; ANTIOXIDANT; GINSENG EXTRACT; HEAT SHOCK PROTEIN 70; HEME OXYGENASE 1; HYDROETHIDINE; NIMODIPINE; PROTOPANAXTRIOL; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; 3-NITROPROPIONIC ACID; HEME OXYGENASE; HMOX1 PROTEIN, RAT; NEUROPROTECTIVE AGENT; NFE2L2 PROTEIN, RAT; NITRO DERIVATIVE; NQO1 PROTEIN, RAT; PROPIONIC ACID DERIVATIVE; PROTOPANAXATRIOL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SAPOGENIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; ASTROCYTE; BODY WEIGHT; CONTROLLED STUDY; CORPUS STRIATUM; GINSENG; HUNTINGTON CHOREA; IMMUNOHISTOCHEMISTRY; LOCOMOTION; MALE; NERVE CELL; NISSL STAINING; NONHUMAN; OXIDATIVE STRESS; RAT; WESTERN BLOTTING; ANIMAL; ANIMAL BEHAVIOR; BASAL GANGLION; CHEMICALLY INDUCED; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; HUMAN; HUNTINGTON DISEASE; METABOLISM; MITOCHONDRION; MOTOR ACTIVITY; PATHOLOGY; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; TIME FACTOR; WEIGHT REDUCTION;

ANIMALS; ANTIOXIDANTS; BASAL GANGLIA; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HEME OXYGENASE (DECYCLIZING); HSP70 HEAT-SHOCK PROTEINS; HUMANS; HUNTINGTON DISEASE; MALE; MITOCHONDRIA; MOTOR ACTIVITY; NAD(P)H DEHYDROGENASE (QUINONE); NEURONS; NEUROPROTECTIVE AGENTS; NF-E2-RELATED FACTOR 2; NITRO COMPOUNDS; PROPIONATES; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SAPOGENINS; SIGNAL TRANSDUCTION; TIME FACTORS; WEIGHT LOSS;

EID: 84936150924     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2014.107     Document Type: Article

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