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Volumn 38, Issue 6, 2011, Pages 657-665

Molecular genetic epidemiology of age-related hearing impairment

Author keywords

Age related hearing impairment; Association study; Linkage analysis; Single nucleotide polymorphism

Indexed keywords

APOLIPOPROTEIN E4; APOLIPOPROTEIN E4 EPSILON; ARYLAMINE ACETYLTRANSFERASE; CYTOCHROME C OXIDASE; CYTOCHROME C OXIDASE SUBUNIT 3; ENDOTHELIN 1; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE T1; GUANOSINE TRIPHOSPHATASE; IQ MOTIF CONTAINING GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN 2; METABOTROPIC RECEPTOR 7; MITOCHONDRIAL DNA; POTASSIUM CHANNEL KCNQ4; REACTIVE OXYGEN METABOLITE; SIRTUIN 1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GRHL2; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 2;

EID: 79959977064     PISSN: 03858146     EISSN: 18791476     Source Type: Journal    
DOI: 10.1016/j.anl.2011.02.005     Document Type: Review
Times cited : (27)

References (74)
  • 1
    • 79959972552 scopus 로고    scopus 로고
    • Understanding the genotype: basic concepts
    • Informa UK Ltd., London, A. Martini, D. Stephens, A.P. Read (Eds.)
    • Read A.P. Understanding the genotype: basic concepts. Genes, hearing, and deafness from molecular biology to clinical practice 2007, Informa UK Ltd., London, pp. 3-17. A. Martini, D. Stephens, A.P. Read (Eds.).
    • (2007) Genes, hearing, and deafness from molecular biology to clinical practice , pp. 3-17
    • Read, A.P.1
  • 2
    • 84921794661 scopus 로고    scopus 로고
    • Age-related hearing impairment: ensemble playing of environmental and genetic factors
    • Informa UK Ltd., London, A. Martini, D. Stephens, A.P. Read (Eds.)
    • Van Laer L., Van Camp G. Age-related hearing impairment: ensemble playing of environmental and genetic factors. Genes, hearing, and deafness from molecular biology to clinical practice 2007, Informa UK Ltd., London, pp. 79-90. A. Martini, D. Stephens, A.P. Read (Eds.).
    • (2007) Genes, hearing, and deafness from molecular biology to clinical practice , pp. 79-90
    • Van Laer, L.1    Van Camp, G.2
  • 3
    • 35148896763 scopus 로고    scopus 로고
    • The complexity of age-related hearing impairment: contributing environmental and genetic factors
    • Van Eyken E., Van Camp G., Van Laer L. The complexity of age-related hearing impairment: contributing environmental and genetic factors. Audiol Neurootol 2007, 12:345-358.
    • (2007) Audiol Neurootol , vol.12 , pp. 345-358
    • Van Eyken, E.1    Van Camp, G.2    Van Laer, L.3
  • 4
    • 0030854184 scopus 로고    scopus 로고
    • Genetics of complex disease: approaches, problems, and solutions
    • Schork N.J. Genetics of complex disease: approaches, problems, and solutions. Am J Respir Crit Care Med 1997, 156:S103-S109.
    • (1997) Am J Respir Crit Care Med , vol.156
    • Schork, N.J.1
  • 5
    • 0142249937 scopus 로고    scopus 로고
    • How to model a complex trait 1. General considerations and suggestions
    • Strauch K., Fimmers R., Baur M.P., Wienker T.F. How to model a complex trait 1. General considerations and suggestions. Hum Hered 2003, 55:202-210.
    • (2003) Hum Hered , vol.55 , pp. 202-210
    • Strauch, K.1    Fimmers, R.2    Baur, M.P.3    Wienker, T.F.4
  • 8
    • 0035153199 scopus 로고    scopus 로고
    • Genetic and environmental influences on self-reported reduced hearing in the old and oldest old
    • Christensen K., Frederiksen H., Hoffman H.J. Genetic and environmental influences on self-reported reduced hearing in the old and oldest old. J Am Geriatr Soc 2001, 49:1512-1517.
    • (2001) J Am Geriatr Soc , vol.49 , pp. 1512-1517
    • Christensen, K.1    Frederiksen, H.2    Hoffman, H.J.3
  • 9
    • 1842507428 scopus 로고    scopus 로고
    • A novel Z-score-based method to analyze candidate genes for age-related hearing impairment
    • Fransen E., Van Laer L., Lemkens N., Caethoven G., Flothmann K., Govaerts P., et al. A novel Z-score-based method to analyze candidate genes for age-related hearing impairment. Ear Hear 2004, 25:133-141.
    • (2004) Ear Hear , vol.25 , pp. 133-141
    • Fransen, E.1    Van Laer, L.2    Lemkens, N.3    Caethoven, G.4    Flothmann, K.5    Govaerts, P.6
  • 10
    • 77953026831 scopus 로고    scopus 로고
    • Heritability of audiometric shape parameters and familial aggregation of presbycusis in an elderly Flemish population
    • Demeester K., van Wieringen A., Hendrickx J.J., Topsakal V., Huyghe J., Fransen E., et al. Heritability of audiometric shape parameters and familial aggregation of presbycusis in an elderly Flemish population. Hear Res 2010, 265:1-10.
    • (2010) Hear Res , vol.265 , pp. 1-10
    • Demeester, K.1    van Wieringen, A.2    Hendrickx, J.J.3    Topsakal, V.4    Huyghe, J.5    Fransen, E.6
  • 11
    • 50949121143 scopus 로고    scopus 로고
    • Genome-wide SNP-based linkage scan identifies a locus on 8q24 for an age-related hearing impairment trait
    • Huyghe J.R., Van Laer L., Hendrickx J.J., Fransen E., Demeester K., Topsakal V., et al. Genome-wide SNP-based linkage scan identifies a locus on 8q24 for an age-related hearing impairment trait. Am J Hum Genet 2008, 83:401-407.
    • (2008) Am J Hum Genet , vol.83 , pp. 401-407
    • Huyghe, J.R.1    Van Laer, L.2    Hendrickx, J.J.3    Fransen, E.4    Demeester, K.5    Topsakal, V.6
  • 14
    • 33748344698 scopus 로고    scopus 로고
    • Presbycusis: a human temporal bone study of individuals with downward sloping audiometric patterns of hearing loss and review of the literature
    • Nelson E.G., Hinojosa R. Presbycusis: a human temporal bone study of individuals with downward sloping audiometric patterns of hearing loss and review of the literature. Laryngoscope 2006, 116:1-12.
    • (2006) Laryngoscope , vol.116 , pp. 1-12
    • Nelson, E.G.1    Hinojosa, R.2
  • 15
    • 0000877874 scopus 로고
    • The detection of autosomal linkage in data which consist of pairs of brothers and sisters of unspecified parentage
    • Penrose L.S. The detection of autosomal linkage in data which consist of pairs of brothers and sisters of unspecified parentage. Ann Eugen 1935, 6:133-138.
    • (1935) Ann Eugen , vol.6 , pp. 133-138
    • Penrose, L.S.1
  • 18
    • 0028169393 scopus 로고
    • Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening
    • Robertson N.G., Khetarpal U., Gutiérrez-Espeleta G.A., Bieber F.R., Morton C.C. Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. Genomics 1994, 23:42-50.
    • (1994) Genomics , vol.23 , pp. 42-50
    • Robertson, N.G.1    Khetarpal, U.2    Gutiérrez-Espeleta, G.A.3    Bieber, F.R.4    Morton, C.C.5
  • 19
    • 34547673530 scopus 로고    scopus 로고
    • IQGAP2 is required for the cadherin-mediated cell-to-cell adhesion in Xenopus laevis embryos
    • Yamashiro S., Abe H., Mabuchi I. IQGAP2 is required for the cadherin-mediated cell-to-cell adhesion in Xenopus laevis embryos. Dev Biol 2007, 308:485-493.
    • (2007) Dev Biol , vol.308 , pp. 485-493
    • Yamashiro, S.1    Abe, H.2    Mabuchi, I.3
  • 20
    • 15944383403 scopus 로고    scopus 로고
    • Gene-environment interactions in human diseases
    • Hunter D.J. Gene-environment interactions in human diseases. Nat Rev Genet 2005, 6:287-298.
    • (2005) Nat Rev Genet , vol.6 , pp. 287-298
    • Hunter, D.J.1
  • 21
    • 0030038103 scopus 로고    scopus 로고
    • Oxidative stress, caloric restriction, and aging
    • Sohal R.S., Weindruch R. Oxidative stress, caloric restriction, and aging. Science 1996, 273:59-63.
    • (1996) Science , vol.273 , pp. 59-63
    • Sohal, R.S.1    Weindruch, R.2
  • 22
    • 33846684240 scopus 로고    scopus 로고
    • Ageing and hearing loss
    • Liu X.Z., Yan D. Ageing and hearing loss. J Pathol 2007, 211:188-197.
    • (2007) J Pathol , vol.211 , pp. 188-197
    • Liu, X.Z.1    Yan, D.2
  • 23
    • 0030297554 scopus 로고    scopus 로고
    • Direct effects of intraperilymphatic reactive oxygen species generation on cochlear function
    • Clerici W.J., Yang L. Direct effects of intraperilymphatic reactive oxygen species generation on cochlear function. Hear Res 1996, 101:14-22.
    • (1996) Hear Res , vol.101 , pp. 14-22
    • Clerici, W.J.1    Yang, L.2
  • 24
    • 0027716121 scopus 로고
    • Glutathione S-transferases in the organ of Corti of the rat: enzymatic activity, subunit composition and immunohistochemical localization
    • el Barbary A., Altschuler R.A., Schacht J. Glutathione S-transferases in the organ of Corti of the rat: enzymatic activity, subunit composition and immunohistochemical localization. Hear Res 1993, 71:80-90.
    • (1993) Hear Res , vol.71 , pp. 80-90
    • el Barbary, A.1    Altschuler, R.A.2    Schacht, J.3
  • 25
    • 0031895404 scopus 로고    scopus 로고
    • Changes in cochlear antioxidant enzyme activity after sound conditioning and noise exposure in the chinchilla
    • Jacono A.A., Hu B., Kopke R.D., Henderson D., Van De Water T.R., Steinman H.M. Changes in cochlear antioxidant enzyme activity after sound conditioning and noise exposure in the chinchilla. Hear Res 1998, 117:31-38.
    • (1998) Hear Res , vol.117 , pp. 31-38
    • Jacono, A.A.1    Hu, B.2    Kopke, R.D.3    Henderson, D.4    Van De Water, T.R.5    Steinman, H.M.6
  • 27
    • 16344386238 scopus 로고    scopus 로고
    • The influence of genetic variation in oxidative stress genes on human noise susceptibility
    • Carlsson P.I., Van Laer L., Borg E., Bondeson M.L., Thys M., Fransen E., et al. The influence of genetic variation in oxidative stress genes on human noise susceptibility. Hear Res 2005, 202:87-96.
    • (2005) Hear Res , vol.202 , pp. 87-96
    • Carlsson, P.I.1    Van Laer, L.2    Borg, E.3    Bondeson, M.L.4    Thys, M.5    Fransen, E.6
  • 28
    • 33744501301 scopus 로고    scopus 로고
    • The role of oxidative stress in noise-induced hearing loss
    • Henderson D., Bielefeld E.C., Harris K.C., Hu B.H. The role of oxidative stress in noise-induced hearing loss. Ear Hear 2006, 27:1-19.
    • (2006) Ear Hear , vol.27 , pp. 1-19
    • Henderson, D.1    Bielefeld, E.C.2    Harris, K.C.3    Hu, B.H.4
  • 31
    • 33847650437 scopus 로고    scopus 로고
    • Age-related hearing loss in CD/1 mice is associated to ROS formation and HIF target proteins up-regulation in the cochlea
    • Riva C., Donadieu E., Magnan J., Lavieille J.P. Age-related hearing loss in CD/1 mice is associated to ROS formation and HIF target proteins up-regulation in the cochlea. Exp Gerontol 2007, 42:327-336.
    • (2007) Exp Gerontol , vol.42 , pp. 327-336
    • Riva, C.1    Donadieu, E.2    Magnan, J.3    Lavieille, J.P.4
  • 32
    • 0035086719 scopus 로고    scopus 로고
    • A novel locus for autosomal dominant, non-syndromic hearing impairment (DFNA18) maps to chromosome 3q22 immediately adjacent to the DM2 locus
    • Bönsch D., Scheer P., Neumann C., Lang-Roth R., Seifert E., Storch P., et al. A novel locus for autosomal dominant, non-syndromic hearing impairment (DFNA18) maps to chromosome 3q22 immediately adjacent to the DM2 locus. Eur J Hum Genet 2001, 9:165-170.
    • (2001) Eur J Hum Genet , vol.9 , pp. 165-170
    • Bönsch, D.1    Scheer, P.2    Neumann, C.3    Lang-Roth, R.4    Seifert, E.5    Storch, P.6
  • 35
    • 0034636056 scopus 로고    scopus 로고
    • KCNQ4, a K+ channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway
    • Kharkovets T., Hardelin J.P., Safieddine S., Schweizer M., El-Amraoui A., Petit C., et al. KCNQ4, a K+ channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway. Proc Natl Acad Sci USA 2000, 97:4333-4338.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 4333-4338
    • Kharkovets, T.1    Hardelin, J.P.2    Safieddine, S.3    Schweizer, M.4    El-Amraoui, A.5    Petit, C.6
  • 37
    • 67649243788 scopus 로고    scopus 로고
    • N-acetyltransferase SNPs: emerging concepts serve as a paradigm for understanding complexities of personalized medicine
    • Hein D.W. N-acetyltransferase SNPs: emerging concepts serve as a paradigm for understanding complexities of personalized medicine. Expert Opin Drug Metab Toxicol 2009, 5:353-366.
    • (2009) Expert Opin Drug Metab Toxicol , vol.5 , pp. 353-366
    • Hein, D.W.1
  • 40
    • 34548827061 scopus 로고    scopus 로고
    • Contribution of the N-acetyltransferase 2 polymorphism NAT2*6A to age-related hearing impairment
    • Van Eyken E., Van Camp G., Fransen E., Topsakal V., Hendrickx J.J., Demeester K., et al. Contribution of the N-acetyltransferase 2 polymorphism NAT2*6A to age-related hearing impairment. J Med Genet 2007, 44:570-578.
    • (2007) J Med Genet , vol.44 , pp. 570-578
    • Van Eyken, E.1    Van Camp, G.2    Fransen, E.3    Topsakal, V.4    Hendrickx, J.J.5    Demeester, K.6
  • 41
    • 14544294519 scopus 로고    scopus 로고
    • Structure and regulation of the drug-metabolizing enzymes arylamine N-acetyltransferases
    • Dupret J.M., Rodrigues-Lima F. Structure and regulation of the drug-metabolizing enzymes arylamine N-acetyltransferases. Curr Med Chem 2005, 12:311-318.
    • (2005) Curr Med Chem , vol.12 , pp. 311-318
    • Dupret, J.M.1    Rodrigues-Lima, F.2
  • 42
    • 38049053663 scopus 로고    scopus 로고
    • The grainyhead like 2 gene (GRHL2), alias TFCP2L3, is associated with age-related hearing impairment
    • Van Laer L., Van Eyken E., Fransen E., Huyghe J.R., Topsakal V., Hendrickx J.J., et al. The grainyhead like 2 gene (GRHL2), alias TFCP2L3, is associated with age-related hearing impairment. Hum Mol Genet 2008, 17:159-169.
    • (2008) Hum Mol Genet , vol.17 , pp. 159-169
    • Van Laer, L.1    Van Eyken, E.2    Fransen, E.3    Huyghe, J.R.4    Topsakal, V.5    Hendrickx, J.J.6
  • 43
    • 0036011240 scopus 로고    scopus 로고
    • A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead
    • Wilanowski T., Tuckfield A., Cerruti L., O'Connell S., Saint R., Parekh V., et al. A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead. Mech Dev 2002, 114:37-50.
    • (2002) Mech Dev , vol.114 , pp. 37-50
    • Wilanowski, T.1    Tuckfield, A.2    Cerruti, L.3    O'Connell, S.4    Saint, R.5    Parekh, V.6
  • 44
    • 0036849301 scopus 로고    scopus 로고
    • Mutation of a transcription factor, TFCP2L3, causes progressive autosomal dominant hearing loss, DFNA28
    • Peters L.M., Anderson D.W., Griffith A.J., Grundfast K.M., San Agustin T.B., Madeo A.C., et al. Mutation of a transcription factor, TFCP2L3, causes progressive autosomal dominant hearing loss, DFNA28. Hum Mol Genet 2002, 11:2877-2885.
    • (2002) Hum Mol Genet , vol.11 , pp. 2877-2885
    • Peters, L.M.1    Anderson, D.W.2    Griffith, A.J.3    Grundfast, K.M.4    San Agustin, T.B.5    Madeo, A.C.6
  • 45
    • 0033597552 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors group I are involved in cochlear neurotransmission
    • Kleinlogel S., Oestreicher E., Arnold T., Ehrenberger K., Felix D. Metabotropic glutamate receptors group I are involved in cochlear neurotransmission. Neuroreport 1999, 10:1879-1882.
    • (1999) Neuroreport , vol.10 , pp. 1879-1882
    • Kleinlogel, S.1    Oestreicher, E.2    Arnold, T.3    Ehrenberger, K.4    Felix, D.5
  • 46
    • 0030298241 scopus 로고    scopus 로고
    • Glutamine synthetase and glutamate metabolism in the guinea pig cochlea
    • Eybalin M., Norenberg M.D., Renard N. Glutamine synthetase and glutamate metabolism in the guinea pig cochlea. Hear Res 1996, 101:93-101.
    • (1996) Hear Res , vol.101 , pp. 93-101
    • Eybalin, M.1    Norenberg, M.D.2    Renard, N.3
  • 48
    • 0035033342 scopus 로고    scopus 로고
    • Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals
    • Sha S.H., Taylor R., Forge A., Schacht J. Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals. Hear Res 2001, 155:1-8.
    • (2001) Hear Res , vol.155 , pp. 1-8
    • Sha, S.H.1    Taylor, R.2    Forge, A.3    Schacht, J.4
  • 51
    • 0021874519 scopus 로고
    • Isolation, characterization, and mapping to chromosome 19 of the human apolipoprotein E gene
    • Das H.K., McPherson J., Bruns G.A., Karathanasis S.K., Breslow J.L. Isolation, characterization, and mapping to chromosome 19 of the human apolipoprotein E gene. J Biol Chem 1985, 260:6240-6247.
    • (1985) J Biol Chem , vol.260 , pp. 6240-6247
    • Das, H.K.1    McPherson, J.2    Bruns, G.A.3    Karathanasis, S.K.4    Breslow, J.L.5
  • 53
    • 0027194791 scopus 로고
    • Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
    • Corder E.H., Saunders A.M., Strittmatter W.J., Schmechel D.E., Gaskell P.C., Small G.W., et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993, 261:921-923.
    • (1993) Science , vol.261 , pp. 921-923
    • Corder, E.H.1    Saunders, A.M.2    Strittmatter, W.J.3    Schmechel, D.E.4    Gaskell, P.C.5    Small, G.W.6
  • 54
    • 66349100472 scopus 로고    scopus 로고
    • Endothelin-1 gene polymorphism and hearing impairment in elderly Japanese
    • Uchida Y., Sugiura S., Nakashima T., Ando F., Shimokata H. Endothelin-1 gene polymorphism and hearing impairment in elderly Japanese. Laryngoscope 2009, 119:938-943.
    • (2009) Laryngoscope , vol.119 , pp. 938-943
    • Uchida, Y.1    Sugiura, S.2    Nakashima, T.3    Ando, F.4    Shimokata, H.5
  • 55
    • 29144477627 scopus 로고    scopus 로고
    • Pharmacological reversal of endothelin-1 mediated constriction of the spiral modiolar artery: a potential new treatment for sudden sensorineural hearing loss
    • Scherer E.Q., Arnold W., Wangemann P. Pharmacological reversal of endothelin-1 mediated constriction of the spiral modiolar artery: a potential new treatment for sudden sensorineural hearing loss. BMC Ear Nose Throat Disord 2005, 5:10.
    • (2005) BMC Ear Nose Throat Disord , vol.5 , pp. 10
    • Scherer, E.Q.1    Arnold, W.2    Wangemann, P.3
  • 56
    • 37649009934 scopus 로고    scopus 로고
    • Expression and significance of endothelin 1 in spiral ganglion cells of guinea pig
    • Xu D., Tang Y., Liu S., Liu J. Expression and significance of endothelin 1 in spiral ganglion cells of guinea pig. Int J Pediatr Otorhinolaryngol 2008, 72:189-192.
    • (2008) Int J Pediatr Otorhinolaryngol , vol.72 , pp. 189-192
    • Xu, D.1    Tang, Y.2    Liu, S.3    Liu, J.4
  • 57
    • 34948890043 scopus 로고    scopus 로고
    • Mitochondrial uncoupling proteins-what is their physiological role?
    • Echtay K.S. Mitochondrial uncoupling proteins-what is their physiological role?. Free Radic Biol Med 2007, 43:1351-1371.
    • (2007) Free Radic Biol Med , vol.43 , pp. 1351-1371
    • Echtay, K.S.1
  • 58
    • 77950289811 scopus 로고    scopus 로고
    • The association between gene polymorphisms in uncoupling proteins and hearing impairment in Japanese elderly
    • Sugiura S., Uchida Y., Nakashima T., Ando F., Shimokata H. The association between gene polymorphisms in uncoupling proteins and hearing impairment in Japanese elderly. Acta Otolaryngol 2010, 130:487-492.
    • (2010) Acta Otolaryngol , vol.130 , pp. 487-492
    • Sugiura, S.1    Uchida, Y.2    Nakashima, T.3    Ando, F.4    Shimokata, H.5
  • 59
    • 0041464712 scopus 로고    scopus 로고
    • Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma
    • Mattiasson G., Shamloo M., Gido G., Mathi K., Tomasevic G., Yi S., et al. Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma. Nat Med 2003, 9:1062-1068.
    • (2003) Nat Med , vol.9 , pp. 1062-1068
    • Mattiasson, G.1    Shamloo, M.2    Gido, G.3    Mathi, K.4    Tomasevic, G.5    Yi, S.6
  • 60
    • 24944562786 scopus 로고    scopus 로고
    • Regulation of mitochondrial uncoupling proteins in mouse inner ear ganglion cells in response to systemic kanamycin challenge
    • Kitahara T., Li-Korotky H.S., Balaban C.D. Regulation of mitochondrial uncoupling proteins in mouse inner ear ganglion cells in response to systemic kanamycin challenge. Neuroscience 2005, 135:639-653.
    • (2005) Neuroscience , vol.135 , pp. 639-653
    • Kitahara, T.1    Li-Korotky, H.S.2    Balaban, C.D.3
  • 61
    • 34848884860 scopus 로고    scopus 로고
    • Changes in mitochondrial uncoupling protein expression in the rat vestibular nerve after labyrinthectomy
    • Kitahara T., Horii A., Kizawa K., Maekawa C., Kubo T. Changes in mitochondrial uncoupling protein expression in the rat vestibular nerve after labyrinthectomy. Neurosci Res 2007, 59:237-242.
    • (2007) Neurosci Res , vol.59 , pp. 237-242
    • Kitahara, T.1    Horii, A.2    Kizawa, K.3    Maekawa, C.4    Kubo, T.5
  • 62
    • 77953627194 scopus 로고    scopus 로고
    • Somatic mitochondrial DNA mutations in mammalian aging
    • Larsson N.G. Somatic mitochondrial DNA mutations in mammalian aging. Annu Rev Biochem 2010, 79:683-706.
    • (2010) Annu Rev Biochem , vol.79 , pp. 683-706
    • Larsson, N.G.1
  • 63
    • 0025836655 scopus 로고
    • Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction
    • Hayashi J., Ohta S., Kikuchi A., Takemitsu M., Goto Y., Nonaka I. Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction. Proc Natl Acad Sci USA 1991, 88:10614-10618.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 10614-10618
    • Hayashi, J.1    Ohta, S.2    Kikuchi, A.3    Takemitsu, M.4    Goto, Y.5    Nonaka, I.6
  • 64
    • 0026608057 scopus 로고
    • MELAS mutation in mtDNA binding site for transcription termination factor causes defects in protein synthesis and in respiration but no change in levels of upstream and downstream mature transcripts
    • Chomyn A., Martinuzzi A., Yoneda M., Daga A., Hurko O., Johns D., et al. MELAS mutation in mtDNA binding site for transcription termination factor causes defects in protein synthesis and in respiration but no change in levels of upstream and downstream mature transcripts. Proc Natl Acad Sci USA 1992, 89:4221-4225.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 4221-4225
    • Chomyn, A.1    Martinuzzi, A.2    Yoneda, M.3    Daga, A.4    Hurko, O.5    Johns, D.6
  • 65
    • 0030849125 scopus 로고    scopus 로고
    • Mitochondrial DNA deletions associated with aging and possibly presbycusis: a human archival temporal bone study
    • Bai U., Seidman M.D., Hinojosa R., Quirk W.S. Mitochondrial DNA deletions associated with aging and possibly presbycusis: a human archival temporal bone study. Am J Otolaryngol 1997, 18:449-453.
    • (1997) Am J Otolaryngol , vol.18 , pp. 449-453
    • Bai, U.1    Seidman, M.D.2    Hinojosa, R.3    Quirk, W.S.4
  • 66
    • 1642267429 scopus 로고    scopus 로고
    • Correlation of cochlear blood supply with mitochondrial DNA common deletion in presbyacusis
    • Dai P., Yang W., Jiang S., Gu R., Yuan H., Han D., et al. Correlation of cochlear blood supply with mitochondrial DNA common deletion in presbyacusis. Acta Otolaryngol 2004, 124:130-136.
    • (2004) Acta Otolaryngol , vol.124 , pp. 130-136
    • Dai, P.1    Yang, W.2    Jiang, S.3    Gu, R.4    Yuan, H.5    Han, D.6
  • 67
    • 0029945725 scopus 로고    scopus 로고
    • Association of mitochondrial DNA deletions and cochlear pathology: a molecular biologic tool
    • Seidman M.D., Bai U., Khan M.J., Murphy M.J., Quirk W.S., Castora F.L., et al. Association of mitochondrial DNA deletions and cochlear pathology: a molecular biologic tool. Laryngoscope 1996, 106:777-783.
    • (1996) Laryngoscope , vol.106 , pp. 777-783
    • Seidman, M.D.1    Bai, U.2    Khan, M.J.3    Murphy, M.J.4    Quirk, W.S.5    Castora, F.L.6
  • 68
    • 66849141801 scopus 로고    scopus 로고
    • Quantification of the mitochondrial DNA common deletion in presbycusis
    • Markaryan A., Nelson E.G., Hinojosa R. Quantification of the mitochondrial DNA common deletion in presbycusis. Laryngoscope 2009, 119:1184-1189.
    • (2009) Laryngoscope , vol.119 , pp. 1184-1189
    • Markaryan, A.1    Nelson, E.G.2    Hinojosa, R.3
  • 69
    • 77953922658 scopus 로고    scopus 로고
    • Major arc mitochondrial DNA deletions in cytochrome c oxidase-deficient human cochlear spiral ganglion cells
    • Markaryan A., Nelson E.G., Hinojosa R. Major arc mitochondrial DNA deletions in cytochrome c oxidase-deficient human cochlear spiral ganglion cells. Acta Otolaryngol 2010, 130:780-787.
    • (2010) Acta Otolaryngol , vol.130 , pp. 780-787
    • Markaryan, A.1    Nelson, E.G.2    Hinojosa, R.3
  • 70
    • 0034056134 scopus 로고    scopus 로고
    • Biologic activity of mitochondrial metabolites on aging and age-related hearing loss
    • Seidman M.D., Khan M.J., Bai U., Shirwany N., Quirk W.S. Biologic activity of mitochondrial metabolites on aging and age-related hearing loss. Am J Otolaryngol 2000, 21:161-167.
    • (2000) Am J Otolaryngol , vol.21 , pp. 161-167
    • Seidman, M.D.1    Khan, M.J.2    Bai, U.3    Shirwany, N.4    Quirk, W.S.5
  • 71
    • 73749087580 scopus 로고    scopus 로고
    • Mitochondrial function as a determinant of life span
    • Lanza I.R., Nair K.S. Mitochondrial function as a determinant of life span. Pflugers Arch 2010, 459:277-289.
    • (2010) Pflugers Arch , vol.459 , pp. 277-289
    • Lanza, I.R.1    Nair, K.S.2
  • 72
    • 77950265945 scopus 로고    scopus 로고
    • Linking functional decline of telomeres, mitochondria and stem cells during ageing
    • Sahin E., Depinho R.A. Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature 2010, 464:520-528.
    • (2010) Nature , vol.464 , pp. 520-528
    • Sahin, E.1    Depinho, R.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.