Enhancing malaria diagnosis through microfluidic cell enrichment and magnetic resonance relaxometry detection

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Kong, Tian Fook ^a,b   Ye, Weijian ^b,c   Peng, Weng Kung ^b   Hou, Han Wei ^a   Marcos, ^a   Preiser, Peter Rainer ^b,c   Nguyen, Nam Trung ^d   Han, Jongyoon ^b,e,f  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b SINGAPORE MIT ALLIANCE FOR RESEARCH AND TECHNOLOGY   (Singapore)

^c NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^d GRIFFITH UNIVERSITY   (Australia)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^f Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASE CONTROL STUDY; ERYTHROCYTE; HUMAN; MALARIA; MICROFLUIDICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARASITEMIA; PARASITOLOGY; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

CASE-CONTROL STUDIES; ERYTHROCYTES; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALARIA; MICROFLUIDICS; PARASITEMIA; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 84935899742     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep11425     Document Type: Article

References (48)

1. World Health Organization. Malaria fact sheet. (2014) Available at: http://www.who.int/mediacentre/factsheets/fs094/en/. (Accessed: 2nd December 2014)
2. World Health Organization. World malaria report 2013. (2013) Available at: http://www.who.int/malaria/publications/world-malaria-report-2013/en/. (Accessed: 2nd December 2014)
3. Sullivan, D. J. Hemozoin: a Biocrystal Synthesized during the Degradation of Hemoglobin. Biopolymers Online. 9, 129-137 (2005).
4. Center for Disease Control & Prevention. Malaria. (2012) Available at: http://www.cdc.gov/malaria/diagnosis-treatment/treatment.html. (Accessed: 2nd December 2014)
5. Tangpukdee, N., Duangdee, C., Wilairatana, P. & Krudsood, S. Malaria diagnosis: a brief review. Korean J. Parasitol. 47, 93-102 (2009).
6. Getahun, A., Deribe, K. & Deribew, A. Determinants of delay in malaria treatment-seeking behaviour for under-five children in south-west ethiopia: a case control study. Malaria J. 9, (2010).
7. Dondorp, A. M. et al. Artemisinin resistance in plasmodium falciparum malaria. N. Engl. J. Med. 361, 455-467 (2009).
8. Ashley, E. A. et al. Spread of artemisinin resistance in plasmodium falciparum malaria. N. Engl. J. Med. 371, 411-423 (2014).
9. Bharti, A. R. et al. Short report: polymerase chain reaction detection of plasmodium vivax and plasmodium falciparum DNA from stored serum samples: implications for retrospective diagnosis of malaria. Am. J. Trop. Med. Hyg. 77, 444-446 (2007).
10. Iqbal, J., Sher, A., Hira, P. R. & Al-Owaish, R. Comparison of the optimal test with PCR for diagnosis of malaria in immigrants. J. Clin. Microbiol. 39, 3644-3646 (1999).
11. Moody, A. Rapid diagnostic tests for malaria parasites. Clin. Bio. Rev. 15, 66-78 (2002).
12. Kawamoto, F. et al. Sequence variation in the 18s rrna gene, a target for pcr-based malaria diagnosis, in plasmodium ovale from southern vietnam. J. Clin. Microbiol. 34, 2287-2289 (1996).
13. Morassin, B., Fabre, R., Berry, A. & Magnaval, J. One year's experience with the polymerase chain reaction as a routine method for the diagnosis of imported malaria. Am. J. Trop. Med. Hyg. 66, 503-508 (2002).
14. Lee, H., Sun, E., Ham, D. & Weissleder, R. Chip-nmr biosensor for detection and molecular analysis of cells. Nat. Med. 14, 869-874 (2008).
15. Haun, J. B. et al. Micro-nmr for rapid molecular analysis of human tumor samples. Sci. Transl. Med. 3, 71ra16 (2011).
16. Issadore, D. et al. Miniature magnetic resonance system for point-of-care diagnostics. Lab Chip 11, 2282-2287 (2011).
17. Peng, W. K., Chen, L. & Han, J. Development of miniaturized, portable magnetic resonance relaxometry system for point-of-care medical diagnosis. Rev. Sci. Instrum. 83, 095115 (2012).
18. Massin, C. et al. High-q factor rf planar microcoils for micro-scale nmr spectroscopy. Sens. Actuators A Phys. 97-98, 280-288 (2002).
19. Hsieh, C. Y., Yeh, Y. T. & Fan, L. S. Multilayer high-aspect-ratio rf coil for nmr applications. Microsyst. Technol. 17, 1311-1317 (2011).
20. Peng, W. K. et al. Micro magnetic resonance relaxometry for label-free, rapid malaria diagnosis. Nat. Med. 20, 1069-1073 (2014).
21. Gascoyne, P. et al. Microsample preparation by dielectrophoresis: isolation of malaria. Lab Chip 2, 70-75 (2002).
22. Shafiee, H., Caldwell, J. L., Sano, M. B. & Davalos, R. V. Contactless dielectrophoresis: a new technique for cell manipulation. Biomed. Microdevices 11, 997-1006 (2009).
23. Ribaut, C. et al. Concentration and purification by magnetic separation of the erythrocytic stages of all human plasmodium species. Malaria J. 7, (2008).
24. Zimmerman, P. A., Thomson, J., Fujioka, H., Collins, W. & M., Z. Diagnosis of malaria by magnetic deposition microscopy. Am. J. Trop. Med. Hyg. 74, 568-572 (2006).
25. Hou, H. W. et al. Deformability based cell margination - a simple microfluidic design for malaria-infected erythrocyte separation. Lab Chip 10, 2605-2613 (2010).
26. Cheng, R., Lai, Y. G. & Chandran, K. B. Three-dimensional fluid-structure interaction simulation of bileaflet mechanical heart valve flow dynamics. Ann. Biomed. Eng. 32, 1471-1483 (2004).
27. Suresh, S. et al. Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria. Acta Biomater. 1, 15-30 (2005).
28. Pierige, F., Serafini, S., Rossi, L. & Magnani, M. Cell-based drug delivery. Adv. Drug Deliv. Rev. 60, 286-295 (2008).
29. Silva, D. C. N. et al. Optical tweezers as a new biomedical tool to measure zeta potential of stored red blood cells. PLoS ONE 7, e31778 (2012).
30. Gottlieb, Y. et al. Physiologically aged red blood cells undergo erythrophagocytosis in vivo but not in vitro. Haematologica 97, 994-1002 (2012).
31. Mendanha, S. A., Anjos, J. L. V., Silva, A. H. M., & Alonso, A. Electron paramagnetic resonance study of lipid and protein membrane components of erythrocytes oxidized with hydrogen peroxide. Braz. J. Med. Biol. Res. 45, 473-481 (2012).
32. Rettig, M. P. et al. Evaluation of biochemical changes during in vivo erythrocyte senescence in the dog. Blood 93, 376-384 (1999).
33. Umbreit, J. Methemoglobin-it's not just blue: a concise review. Am. J. Hematol. 82, 134-144 (2007).
34. Kanias, T. & Acker, J. P. Biopreservation of red blood cells - the struggle with hemoglobin oxidation. FEBS J. 277, 343-356 (2010).
35. Low, P. S., Waugh, S. M., Zinke, K. & Drenckhahn, D. The role of hemoglobin denaturation and band 3 clustering in red blood cell aging. Science 227, 531-533 (1985).
36. Li, X. & Zhou, Y. Microfluidic Devices for Biomedical Applications [303-306] (Woodhead Publishing, Cambridge, 2013).
37. Shevkoplyas, S. S., Yoshida, T., Munn, L. L. & Bitensky, M. W. Biomimetic autoseparation of leukocytes from whole blood in a microfluidic device. Anal. Chem. 77, 933-937 (2005).
38. Kumar, A. & Graham, M. D. Margination and segregation in confined flows of blood and other multicomponent suspensions. Soft Matter 8, 10536-10548 (2012).
39. Goldsmith, H. L., Cokelet, G. R. & Gaehtgens, P. Robin fahraeus: evolution of his concepts in cardiovascular physiology. Am. J. Physiol. 257, H1005-H1015 (1989).
40. Zhang, J., Li, W., Li, M., Alici, G. & Nguyen, N.-T. Particle inertial focusing and its mechanism in a serpentine microchannel. Microfluid. Nanofluid. 17, 305-316 (2014).
41. Zhao, H., Shaqfeh, E. S. G. & Narsimhan, V. Shear-induced particle migration and margination in a cellular suspension. Phys. Fluids 24, 011902 (2012).
42. Zhang, J., Yan, S., Li, W., Alici, G. & Nguyen, N.-T. High throughput extraction of plasma using a secondary flow-aided inertial microfluidic device. RSC Adv. 4, 33149-33159 (2014).
43. Eaton, P., Zuzarte-Luis, V., Mota, M. M., Santos, N. C. & Prudlncio, M. Infection by plasmodium changes shape and stiffness of hepatic cells. Nanomed. Nanotechnol. 8, 17-19 (2012).
44. Chen, Y. et al. Rare cell isolation and analysis in microfluidics. Lab Chip 14, 626-645 (2014).
45. Glenister, F. K., Coppel, R. L., Cowman, A. F., Mohandas, N. & Cooke, B. M. Contribution of parasite proteins to altered mechanical properties of malaria-infected red blood cells. Blood 99, 1060-1063 (2002).
46. Moll, K., Ljungström, I., Perlmann, H., Scherf, A. & Wahlgren, M. Methods in Malaria Research (MR4/ATCC, Virginia, 2013).
47. Moore, L. R. et al. Hemoglobin degradation in malaria-infected erythrocytes determined from live cell magnetophoresis. FASEB J. 20, 747-749 (2006).
48. Saul, A., Myler, P., Elliott, T. & Kidson, C. Purification of mature schizonts of plasmodium falciparum on colloidal silica gradients. Bull. World Health Organ. 60, 755-759 (1982).