Deep sequencing of multiple regions of glial tumors reveals spatial heterogeneity for mutations in clinically relevant genes

Genome Biology

Volumn 15, Issue 12, 2014, Pages

  Kumar, Akash ^a   Boyle, Evan A ^a   Tokita, Mari ^a,b   Mikheev, Andrei M ^a   Sanger, Michelle C ^c   Girard, Emily ^c   Silber, John R ^a   Gonzalez Cuyar, Luis F ^a   Hiatt, Joseph B ^a   Adey, Andrew ^a   Lee, Choli ^a   Kitzman, Jacob O ^a   Born, Donald E ^a   Silbergeld, Daniel L ^a   Olson, James M ^c   Rostomily, Robert C ^a   Shendure, Jay ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c USA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; ISOCITRATE DEHYDROGENASE 1; K RAS PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PROTEIN P53; STEM CELL FACTOR RECEPTOR; PRB1 PROTEIN, HUMAN; PROLINE RICH PROTEIN; TP53 PROTEIN, HUMAN;

ADULT; ARTICLE; ASTROCYTOMA; CELL HETEROGENEITY; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; COPY NUMBER VARIATION; DNA ISOLATION; DNA REPAIR; EPENDYMOMA; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE MUTATION; GENE SEQUENCE; GENE TARGETING; GLIOBLASTOMA; GLIOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; NEXT GENERATION SEQUENCING; OLIGODENDROGLIOMA; POINT MUTATION; POLYMERASE CHAIN REACTION; TUMOR GENE; BRAIN TUMOR; DNA SEQUENCE; GENETIC HETEROGENEITY; GENETICS; HIGH THROUGHPUT SEQUENCING; MOLECULAR GENETICS; PATHOLOGY; PROCEDURES;

BRAIN NEOPLASMS; GENE AMPLIFICATION; GENETIC HETEROGENEITY; GLIOBLASTOMA; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MOLECULAR SEQUENCE DATA; OLIGODENDROGLIOMA; POINT MUTATION; PROTO-ONCOGENE PROTEINS C-KIT; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA; SALIVARY PROLINE-RICH PROTEINS; SEQUENCE ANALYSIS, DNA; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84935860943     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/s13059-014-0530-z     Document Type: Article

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