Protective effects of heparin on endothelial cells in sepsis

International Journal of Clinical and Experimental Medicine

Volumn 8, Issue 4, 2015, Pages 5547-5552

  Ma, Jianqi ^a   Bai, Jinghui ^a  

^a LIAONING CANCER HOSPITAL AND INSTITUTE   (China)

Author keywords

Heparin; Inflammation; Signal regulating mechanism; Vascular endothelial cells

Indexed keywords

ACTIVATED PROTEIN C; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HEPARIN; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; THROMBOMODULIN;

ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; HISTONE METHYLATION; HUMAN; HUMAN CELL; INFLAMMATION; PROMOTER REGION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEPSIS; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 84935859047     PISSN: None     EISSN: 19405901     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Haller H. Endothelial function. General considerations. Drugs 1997; 53 Suppl 1: 1-10.
2. Haller H. Modulation of endothelial function: strategy for long-term cardiovascular protection. J Hypertens Suppl 1996; 14: S27-32.
3. Guerci B, Bohme P, Kearney-Schwartz A, Zannad F and Drouin P. Endothelial dysfunction and type 2 diabetes. Part 2: altered endothelial function and the effects of treatments in type 2 diabetes mellitus. Diabetes Metab 2001; 27: 436-447.
4. Schiffrin EL. A critical review of the role of endothelial factors in the pathogenesis of hypertension. J Cardiovasc Pharmacol 2001; 38 Suppl 2: S3-6.
5. Verma S and Anderson TJ. Fundamentals of endothelial function for the clinical cardiologist. Circulation 2002; 105: 546-549.
6. Conger JD. Endothelial regulation of vascular tone. Hosp Pract (Off Ed) 1994; 29: 117-122, 125-116.
7. Vane JR, Anggard EE and Botting RM. Regulatory functions of the vascular endothelium. N Engl J Med 1990; 323: 27-36.
8. Cines DB, Pollak ES, Buck CA, Loscalzo J, Zimmerman GA, McEver RP, Pober JS, Wick TM, Konkle BA, Schwartz BS, Barnathan ES, McCrae KR, Hug BA, Schmidt AM and Stern DM. Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood 1998; 91: 3527-3561.
9. Sica DA. Device-guided breathing and hypertension: a yet to be determined positioning. Cardiol Rev 2011; 19: 45-46.
10. Gonzalez MA and Selwyn AP. Endothelial function, inflammation, and prognosis in cardiovascular disease. Am J Med 2003; 115 Suppl 8A: 99S-106S.
11. Libby P. Inflammation in atherosclerosis. Arterioscler Thromb Vasc Biol 2012; 32: 2045-2051.
12. Furchgott RF and Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980; 288: 373-376.
13. Park JB, Charbonneau F and Schiffrin EL. Correlation of endothelial function in large and small arteries in human essential hypertension. J Hypertens 2001; 19: 415-420.
14. Khan BV, Harrison DG, Olbrych MT, Alexander RW and Medford RM. Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redox-sensitive transcriptional events in human vascular endothelial cells. Proc Natl Acad Sci U S A 1996; 93: 9114-9119.
15. Mombouli JV. ACE inhibition, endothelial function and coronary artery lesions. Role of kinins and nitric oxide. Drugs 1997; 54 Suppl 5: 12-22.
16. Bonetti PO, Lerman LO and Lerman A. Endothelial dysfunction: a marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol 2003; 23: 168-175.
17. Wautier JL, Setiadi H, Vilette D, Weill D and Wautier MP. Leukocyte adhesion to endothelial cells. Biorheology 1990; 27: 425-432.
18. Wautier JL, Wautier MP, Pintigny D, Galacteros F, Courillon A, Passa P and Caen JP. Factors involved in cell adhesion to vascular endothelium. Blood Cells 1983; 9: 221-234.
19. Xiang GD, Sun HL and Zhao LS. Changes of osteoprotegerin before and after insulin therapy in type 1 diabetic patients. Diabetes Res Clin Pract 2007; 76: 199-206.
20. Cavieres V, Valdes K, Moreno B, Moore-Carrasco R and Gonzalez DR. Vascular hypercontractility and endothelial dysfunction before development of atherosclerosis in moderate dyslipidemia: role for nitric oxide and interleukin-6. Am J Cardiovasc Dis 2014; 4: 114-122.
21. Hartge MM, Kintscher U and Unger T. Endothelial dysfunction and its role in diabetic vascular disease. Endocrinol Metab Clin North Am 2006; 35: 551-560, viii-ix.
22. Petrica L, Vlad A, Gluhovschi G, Gadalean F, Dumitrascu V, Gluhovschi C, Velciov S, Bob F, Vlad D, Popescu R, Milas O and Ursoniu S. Proximal tubule dysfunction is associated with podocyte damage biomarkers nephrin and vascular endothelial growth factor in type 2 diabetes mellitus patients: a cross-sectional study. PLoS One 2014; 9: e112538.