The mechanism of ligand-induced activation or inhibition of μ- And κ-opioid receptors

Angewandte Chemie - International Edition

Volumn 54, Issue 26, 2015, Pages 7560-7563

  Yuan, Shuguang ^a   Palczewski, Krzysztof ^b   Peng, Qian ^c   Kolinski, Michal ^d   Vogel, Horst ^a   Filipek, Slawomir ^e  

^a EPFL   (Switzerland)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

^e UNIVERSITY OF WARSAW   (Poland)

Author keywords

GPCRs; molecular dynamics; protein models; receptors; signal transduction

Indexed keywords

CHEMICAL ACTIVATION; MOLECULAR DYNAMICS; MOLECULES; PROTEINS; SIGNAL TRANSDUCTION;

G PROTEIN COUPLED RECEPTORS; GPCRS; KAPPA OPIOID RECEPTOR; LIGAND-RECEPTOR INTERACTIONS; MOLECULAR DYNAMICS SIMULATIONS; PROTEIN MODELS; RECEPTORS; SOLVENT ACCESSIBLE SURFACE AREAS;

LIGANDS;

KAPPA OPIATE RECEPTOR; LIGAND; MU OPIATE RECEPTOR; PROTEIN BINDING;

METABOLISM; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION;

LIGANDS; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; SIGNAL TRANSDUCTION;

EID: 84935832133     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201501742     Document Type: Article

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