Non-motor symptoms burden in treated and untreated early Parkinson's disease patients: Argument for non-motor subtypes

European Journal of Neurology

Volumn 22, Issue 8, 2015, Pages 1145-1150

  Zis, P ^a   Martinez Martin, P ^b   Sauerbier, A ^a,c   Rizos, A ^a   Sharma, J C ^d   Worth, P F ^e   Sophia, R ^f   Silverdale, M ^g   Chaudhuri, K Ray ^a,c  

^a KING'S COLLEGE HOSPITAL NHS FOUNDATION TRUST   (United Kingdom)

^b CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d UNITED LINCOLNSHIRE HOSPITALS NHS TRUST   (United Kingdom)

^e ADDENBROOKE S HOSPITAL   (United Kingdom)

^f YEOVIL DISTRICT HOSPITAL NHS FOUNDATION TRUST   (United Kingdom)

^g SALFORD ROYAL NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Drug na ve; Early Parkinson's disease; Non motor symptoms; Parkinson's disease

Indexed keywords

LEVODOPA;

AGED; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DIZZINESS; FATIGUE; FEMALE; HOSPITAL ANXIETY AND DEPRESSION SCALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEMORY DISORDER; MINI MENTAL STATE EXAMINATION; MULTICENTER STUDY (TOPIC); NOCTURIA; NON MOTOR SYMPTOMS SCALE; PARKINSON DISEASE; PRIORITY JOURNAL; QUALITY OF LIFE; RATING SCALE; SADNESS; SYMPTOMATOLOGY; URINARY FREQUENCY; URINARY URGENCY; CLINICAL TRIAL; COMPLICATION; COST OF ILLNESS; CROSS-SECTIONAL STUDY; MEMORY DISORDERS; MIDDLE AGED; MULTICENTER STUDY; PATHOPHYSIOLOGY; SEVERITY OF ILLNESS INDEX; URINATION DISORDERS;

AGED; COST OF ILLNESS; CROSS-SECTIONAL STUDIES; FATIGUE; FEMALE; HUMANS; MALE; MEMORY DISORDERS; MIDDLE AGED; PARKINSON DISEASE; SEVERITY OF ILLNESS INDEX; URINATION DISORDERS;

EID: 84935447180     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/ene.12733     Document Type: Article

References (31)

1. Sauerbier A, Ray Chaudhuri K. Non-motor symptoms: the core of multi-morbid Parkinson's disease. Br J Hosp Med (Lond) 2014; 75: 18-24.
2. Martinez-Martin P, Rodriguez-Blazquez C, Kurtis MM, Chaudhuri KR, NMSS Validation Group. The impact of non-motor symptoms on health-related quality of life of patients with Parkinson's disease. Mov Disord 2011; 26: 399-406.
3. Riedel O, Klotsche J, Spottke A, et al. Frequency of dementia, depression, and other neuropsychiatric symptoms in 1449 outpatients with Parkinson's disease. J Neurol 2010; 257: 1073-1082.
4. Tolosa E, Gaig C, Santamaría J, Compta Y. Diagnosis and the premotor phase of Parkinson disease. Neurology 2009; 72: S12-S20.
5. Erro R, Santangelo G, Picillo M, et al. Link between non-motor symptoms and cognitive dysfunctions in de novo, drug-naive PD patients. J Neurol 2012; 259: 1808-1813.
6. Erro R, Picillo M, Vitale C, et al. Non-motor symptoms in early Parkinson's disease: a 2-year follow-up study on previously untreated patients. J Neurol Neurosurg Psychiatry 2013; 84: 14-17.
7. Chaudhuri KR, Martinez-Martin P, Schapira AH, et al. International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease: the NMSQuest study. Mov Disord 2006; 21: 916-923.
8. Chaudhuri KR, Martinez-Martin P, Brown RG, et al. The metric properties of a novel non-motor symptoms scale for Parkinson's disease: results from an international pilot study. Mov Disord 2007; 22: 1901-1911.
9. Mollenhauer B, Trautmann E, Sixel-Döring F, et al., DeNoPa Study Group. Nonmotor and diagnostic findings in subjects with de novo Parkinson disease of the DeNoPa cohort. Neurology 2013; 81: 1226-1234.
10. Zis P, Rizos A, Martinez-Martin P, et al. Non-motor symptoms profile and burden in drug naïve versus long-term Parkinson's disease patients. J Parkinsons Dis 2014; 4: 541-547.
11. Khoo TK, Yarnall AJ, Duncan GW, et al. The spectrum of nonmotor symptoms in early Parkinson disease. Neurology 2013; 80: 276-281.
12. Adler CH, Beach TG, Hentz JG, et al. Low clinical diagnostic accuracy of early versus advanced Parkinson disease: clinicopathologic study. Neurology 2014; 83: 406-412.
13. Hughes AJ, Daniel SE, Kilford L, Lees AJ. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 1992; 55: 181-184.
14. Hoehn MM, Yahr MD. Parkinsonism: onset, progression and mortality. Neurology 1967; 17: 427-442.
15. Martínez-Martín P, Benito-León J, Burguera JA, et al. The SCOPA-Motor Scale for assessment of Parkinson's disease is a consistent and valid measure. J Clin Epidemiol 2005; 58: 674-679.
16. Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Neurol Scand 1983; 67: 361-370.
17. Folstein MF, Folstein SE, McHugh PR. 'Mini-mental state'. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 189-198.
18. Ray Chaudhuri K, Rojo JM, Schapira AH, et al. A proposal for a comprehensive grading of Parkinson's disease severity combining motor and non-motor assessments: meeting an unmet need. PLoS ONE 2013; 8: e57221.
19. Erro R, Vitale C, Amboni M, et al. The heterogeneity of early Parkinson's disease: a cluster analysis on newly diagnosed untreated patients. PLoS One 2013; 8: e70244.
20. Todorova A, Jenner P, Ray Chaudhuri K. Non-motor Parkinson's: integral to motor Parkinson's, yet often neglected. Pract Neurol 2014; 14: 310-322.
21. Cholerton BA, Zabetian CP, Wan JY, et al. Evaluation of mild cognitive impairment subtypes in Parkinson's disease. Mov Disord 2014; 29: 756-764.
22. Pedersen KF, Alves G, Brønnick K, Aarsland D, Tysnes OB, Larsen JP. Apathy in drug-naïve patients with incident Parkinson's disease: the Norwegian Park West study. J Neurol 2010; 257: 217-223.
23. Wallace VCJ, Chaudhuri KR. Unexplained lower limb pain in Parkinson's disease: a phenotypic variant of 'painful Parkinson's disease'. Park Rel Disord 2014; 20: 122-124.
24. Sharma JC, Turton J. Olfaction, dyskinesia and profile of weight change in Parkinson's disease: identifying neurodegenerative phenotypes. Parkinsonism Relat Disord 2012; 18: 964-970.
25. Romenets SR, Gagnon JF, Latreille V, et al. Rapid eye movement sleep behavior disorder and subtypes of Parkinson's disease. Mov Disord 2012; 8: 996-1003.
26. Brown RG, Landau S, Hindle JV, et al., PROMS-PD Study Group. Depression and anxiety related subtypes in Parkinson's disease. J Neurol Neurosurg Psychiatry 2011; 82: 803-809.
27. Martinez-Martin P, Rodriguez-Blazquez C, Abe K, et al. International study on the psychometric attributes of the Non-Motor Symptoms Scale in Parkinson disease. Neurology 2009; 73: 1584-1591.
28. Müller B, Assmus J, Larsen JP, Haugarvoll K, Skeie GO, Tysnes OB, Park West study group. Autonomic symptoms and dopaminergic treatment in de novo Parkinson's disease. Acta Neurol Scand 2013; 127: 290-294.
29. Kehagia AA, Barker RA, Robbins TW. Neuropsychological and clinical heterogeneity of cognitive impairment and dementia in patients with Parkinson's disease. Lancet Neurol 2010; 9: 1200-1213.
30. Williams-Gray CH, Mason SL, Evans JR, et al. The CamPaIGN study of Parkinson's disease: 10-year outlook in an incident population-based cohort. J Neurol Neurosurg Psychiatry 2013; 84: 1258-1264.
31. Halliday G, Lees A, Stern M. Milestones in Parkinson's disease - clinical and pathologic features. Mov Disord 2011; 26: 1015-1021.