Vitamin B-12 status differs among pregnant, lactating, and control women with equivalent nutrient intakes

Journal of Nutrition

Volumn 145, Issue 7, 2015, Pages 1507-1514

  Bae, Sajin ^a   West, Allyson A ^a   Yan, Jian ^a   Jiang, Xinyin ^a   Perry, Cydne A ^a   Malysheva, Olga ^a   Stabler, Sally P ^b   Allen, Robert H ^b   Caudill, Marie A ^a  

^a Division of Nutritional Sciences Cornell University ^*  (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Controlled feeding study; Holotranscobalamin; Homocysteine; Lactation; Methylmalonic acid; Pregnancy; Reproductive state; Vitamin B 12; Women of reproductive age

Indexed keywords

CHOLINE; CYANOCOBALAMIN; HOMOCYSTEINE; BIOLOGICAL MARKER; METHYLMALONIC ACID; TRACE ELEMENT;

ADULT; ARTICLE; BODY MASS; BREAST MILK; CLINICAL ARTICLE; CONTROLLED STUDY; ETHNICITY; FEMALE; GESTATIONAL AGE; HUMAN; LACTATION; PREGNANCY; PREGNANT WOMAN; PRENATAL CARE; RANDOMIZED CONTROLLED TRIAL; VITAMIN BLOOD LEVEL; VITAMIN INTAKE; BLOOD; BREAST FEEDING; CALORIC INTAKE; DIET SUPPLEMENTATION; DIETARY REFERENCE INTAKE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; NORMAL HUMAN; PUERPERIUM; URINE; YOUNG ADULT;

ADULT; BIOLOGICAL MARKERS; BREAST FEEDING; CHOLINE; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ENERGY INTAKE; FEMALE; HEALTHY VOLUNTEERS; HOMOCYSTEINE; HUMANS; LACTATION; METHYLMALONIC ACID; MICRONUTRIENTS; POSTPARTUM PERIOD; PREGNANCY; RECOMMENDED DIETARY ALLOWANCES; VITAMIN B 12; YOUNG ADULT;

EID: 84935447062     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.115.210757     Document Type: Article

References (50)

1. Institute of Medicine. Dietary Reference Intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. Washington (DC): National Academies Press; 1998.
2. Bor MV, von Castel-Roberts KM, Kauwell GP, Stabler SP, Allen RH, Maneval DR, Bailey LB, Nexo E. Daily intake of 4 to 7 microg dietary vitamin B-12 is associated with steady concentrations of vitamin B-12-related biomarkers in a healthy young population. Am J Clin Nutr 2010;91:571-7.
3. Bor MV, Lydeking-Olsen E, Møller J, Nexø E. A daily intake of approximately 6 microg vitamin B-12 appears to saturate all the vitamin B-12-related variables in Danish postmenopausal women. Am J Clin Nutr 2006;83:52-8.
4. Tucker KL, Rich S, Rosenberg I, Jacques P, Dallal G, Wilson PW, Selhub J. Plasma vitamin B-12 concentrations relate to intake source in the Framingham Offspring Study. Am J Clin Nutr 2000;71: 514-22.
5. Vogiatzoglou A, Smith AD, Nurk E, Berstad P, Drevon CA, Ueland PM, Vollset SE, Tell GS, Refsum H. Dietary sources of vitamin B-12 and their association with plasma vitamin B-12 concentrations in the general population: the Hordaland Homocysteine Study. Am J Clin Nutr 2009;89:1078-87.
6. Molloy AM, Kirke PN, Brody LC, Scott JM, Mills JL. Effects of folate and vitamin B12 deficiencies during pregnancy on fetal, infant, and child development. Food Nutr Bull 2008;29:S101-11.
7. Kirke PN, Molloy AM, Daly LE, Burke H, Weir DG, Scott JM. Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects. Q J Med 1993;86:703-8.
8. Ronnenberg AG, Goldman MB, Chen D, Aitken IW, Willett WC, Selhub J, Xu X. Preconception homocysteine and B vitamin status and birth outcomes in Chinese women. Am J Clin Nutr 2002;76: 1385-91.
9. Muthayya S, Kurpad AV, Duggan CP, Bosch RJ, Dwarkanath P, Mhaskar A, Mhaskar R, Thomas A, Vaz M, Bhat S, et al. Low maternal vitamin B12 status is associated with intrauterine growth retardation in urban South Indians. Eur J Clin Nutr 2006;60:791-801.
10. Cikot RJ, Steegers-Theunissen RP, Thomas CM, de Boo TM, Merkus HM, Steegers EA. Longitudinal vitamin and homocysteine levels in normal pregnancy. Br J Nutr 2001;85:49-58.
11. Koebnick C, Heins UA, Dagnelie PC, Wickramasinghe SN, Ratnayaka ID, Hothorn T, Pfahlberg AB, Hoffmann I, Lindemans J, Leitzmann C. Longitudinal concentrations of vitamin B(12) and vitamin B(12)-binding proteins during uncomplicated pregnancy. Clin Chem 2002;48: 928-33.
12. Milman N, Byg KE, Bergholt T, Eriksen L, Hvas AM. Cobalamin status during normal pregnancy and postpartum: a longitudinal study comprising 406 Danish women. Eur J Haematol 2006;76:521-5.
13. Murphy MM, Molloy AM, Ueland PM, Fernandez-Ballart JD, Schneede J, Arija V, Scott JM. Longitudinal study of the effect of pregnancy on maternal and fetal cobalamin status in healthy women and their offspring. J Nutr 2007;137:1863-7.
14. Greibe E, Lildballe DL, Streym S, Vestergaard P, Rejnmark L, Mosekilde L, Nexo E. Cobalamin and haptocorrin in human milk and cobalamin-related variables in mother and child: a 9-mo longitudinal study. Am J Clin Nutr 2013;98:389-95.
15. Allen LH. B vitamins in breast milk: relative importance of maternal status and intake, and effects on infant status and function. Adv Nutr 2012;3:362-9.
16. Dror DK, Allen LH. Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible mechanisms. Nutr Rev 2008;66:250-5.
17. Casella EB, Valente M, de Navarro JM, Kok F. Vitamin B12 deficiency in infancy as a cause of developmental regression. Brain Dev 2005;27:592-4.
18. Grattan-Smith PJ, Wilcken B, Procopis PG, Wise GA. The neurological syndrome of infantile cobalamin deficiency: developmental regression and involuntary movements. Mov Disord 1997;12:39-46.
19. Mørkbak AL, Ramlau-Hansen CH, Møller UK, Henriksen TB, Møller J, Nexø E. A longitudinal study of serum cobalamins and its binding proteins in lactating women. Eur J Clin Nutr 2007;61:184-9.
20. Ramlau-Hansen CH, Møller UK, Henriksen TB, Nexø E, Møller J. Folate and vitamin B12 in relation to lactation: a 9-month postpartum follow-up study. Eur J Clin Nutr 2006;60:120-8.
21. Hure AJ, Collins CE, Smith R. A longitudinal study of maternal folate and vitamin B12 status in pregnancy and postpartum, with the same infant markers at 6 months of age. Matern Child Health J 2012;16: 792-801.
22. Yan J, Jiang X, West AA, Perry CA, Malysheva OV, Devapatla S, Pressman E, Vermeylen F, Stabler SP, Allen RD, et al. Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans. Am J Clin Nutr 2012;95:1060-71.
23. West AA, Yan J, Perry CA, Jiang X, Malysheva OV, Caudill MA. Folate-status response to a controlled folate intake in nonpregnant, pregnant, and lactating women. Am J Clin Nutr 2012;96: 789-800.
24. USDA, Agricultural Research Service. USDA National Nutrient Database for Standard Reference, Release 22. Nutrient data laboratory home page; 2009 [cited 2009 Oct 14]. Available from: http://www.ars.usda.gov/ba/bhnrc/ndl.
25. Otten J, Pitzi H, Meyers L; National Research Council. Dietary Reference Intakes: the essential guide to nutrient requirements. Washington (DC): National Academies Press; 2006. p. 196-201.
26. Koletzko B, Cetin I, Brenna JT. Dietary fat intakes for pregnant and lactating women. Br J Nutr 2007;98:873-7.
27. Stabler SP, Marcell PD, Podell ER, Allen RH. Quantitation of total homocysteine, total cysteine, and methionine in normal serum and urine using capillary gas chromatography-mass spectrometry. Anal Biochem 1987;162:185-96.
28. Marcell PD, Stabler SP, Podell ER, Allen RH. Quantitation of methylmalonic acid and other dicarboxylic acids in normal serum and urine using capillary gas chromatography-mass spectrometry. Anal Biochem 1985;150:58-66.
29. Hampel D, Shahab-Ferdows S, Domek JM, Siddiqua T, Raqib R, Allen LH. Competitive chemiluminescent enzyme immunoassay for vitamin B12 analysis in human milk. Food Chem 2014;153:60-5.
30. von Castel-Dunwoody KM, Kauwell GPA, Shelnutt KP, Vaughn JD, Griffin ER, Maneval DR, Theriaque DW, Bailey LB. Transcobalamin 776C→G polymorphism negatively affects vitamin B-12 metabolism. Am J Clin Nutr 2005;81:1436-41.
31. Garrod MG, Allen LH, Haan MN, Green R, Miller JW. Transcobalamin C776G genotype modifies the association between vitamin B12 and homocysteine in older Hispanics. Eur J Clin Nutr 2010;64:503-9.
32. Garrod MG, Green R, Allen LH, Mungas DM, Jagust WJ, Haan MN, Miller JW. Fraction of total plasma vitamin B12 bound to transcobalamin correlates with cognitive function in elderly Latinos with depressive symptoms. Clin Chem 2008;54:1210-7.
33. Stabler SP, Allen RH, Savage DG, Lindenbaum J. Clinical spectrum and diagnosis of cobalamin deficiency. Blood 1990;76:871-81.
34. Herrmann W, Schorr H, Obeid R, Geisel J. Vitamin B-12 status, particularly holotranscobalamin II and methylmalonic acid concentrations, and hyperhomocysteinemia in vegetarians. AmJ Clin Nutr 2003;78: 131-6.
35. Lindgren A, Kilander A, Bagge E, Nexø E. Holotranscobalamin-a sensitive marker of cobalamin malabsorption. Eur J Clin Invest 1999;29: 321-9.
36. Green R. Indicators for assessing folate and vitamin B-12 status and for monitoring the efficacy of intervention strategies. Am J Clin Nutr 2011;94:666S-72S.
37. Bartels PC, Helleman PW, Soons JB. Investigation of red cell sizedistribution histograms related to folate, vitamin B12 and iron state in the course of pregnancy. Scand J Clin Lab Invest 1989;49:763-71.
38. Bruinse HW, van den Berg H. Changes of some vitamin levels during and after normal pregnancy. Eur J Obstet Gynecol Reprod Biol 1995;61:31-7.
39. Faupel-Badger JM, Hsieh CC, Troisi R, Lagiou P, Potischman N. Plasma volume expansion in pregnancy: implications for biomarkers in population studies. Cancer Epidemiol Biomarkers Prev 2007;16:1720-3.
40. Schneider H, Miller RK. Receptor-mediated uptake and transport of macromolecules in the human placenta. Int J Dev Biol 2010;54: 367-75.
41. Morkbak AL, Poulsen SS, Nexo E. Haptocorrin in humans. Clin Chem Lab Med 2007;45:1751-9.
42. Herbert V. Staging vitamin B-12 (cobalamin) status in vegetarians. Am J Clin Nutr 1994;59:1213S-22S.
43. Quadros EV. Advances in the understanding of cobalamin assimilation and metabolism. Br J Haematol 2010;148:195-204.
44. Adkins Y, Lönnerdal B. High affinity binding of the transcobalamin II-cobalamin complex and mRNA expression of haptocorrin by human mammary epithelial cells. Biochim Biophys Acta 2001;1528: 43-8.
45. Metz J, McGrath K, Bennett M, Hyland K, Bottiglieri T. Biochemical indices of vitamin B12 nutrition in pregnant patients with subnormal serum vitamin B12 levels. Am J Hematol 1995;48:251-5.
46. Pardo J, Peled Y, Bar J, Hod M, Sela BA, Rafael ZB, Orvieto R. Evaluation of low serum vitamin B(12) in the non-anaemic pregnant patient. Hum Reprod 2000;15:224-6.
47. Walker MC, Smith GN, Perkins SL, Keely EJ, Garner PR. Changes in homocysteine levels during normal pregnancy. Am J Obstet Gynecol 1999;180:660-4.
48. Andersson A, Hultberg B, Brattström L, Isaksson A. Decreased serum homocysteine in pregnancy. Eur J Clin Chem Clin Biochem 1992;30: 377-9.
49. Kang SS, Wong PW, Zhou JM, Cook HY. Total homocyst(e)ine in plasma and amniotic fluid of pregnant women. Metabolism 1986;35: 889-91.
50. Herbert V, Das KC. Folic acid and vitamin B12. In: Shils ME, Olson JA, Shike M, editors. Modern nutrition in health and disease. 8th ed. Philadelphia: Lea and Febiger; 1994. p. 402-25.