Exhaled breath condensate pepsin: Potential noninvasive test for gastroesophageal reflux in COPD and bronchiectasis

Respiratory Care

Volumn 60, Issue 2, 2015, Pages 244-250

  Lee, Annemarie L ^a,b,d   Button, Brenda M ^b,c,e   Denehy, Linda ^a   Roberts, Stuart ^c,e   Bamford, Tiffany ^e,f   Mu, Fi Tjen ^e   Mifsud, Nicole ^e   Stirling, Robert ^c,e   Wilson, John W ^c,e  

^a THE UNIVERSITY OF MELBOURNE   (Australia)

^b Physiotherapy Department   (Australia)

^c Department of Allergy Immunology and Respiratory Medicine ^*  (Australia)

^d AUSTIN HEALTH   (Australia)

^e MONASH UNIVERSITY   (Australia)

^f Janssen Pharmaceuticals Johnson and Johnson   (Australia)

Author keywords

Bronchiectasis; COPD; Exhaled breath condensate; Gastroesophageal rejlux

Indexed keywords

PEPSIN A; BIOLOGICAL MARKER;

ADULT; ARTICLE; BRONCHIECTASIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ESOPHAGEAL PH MONITORING; EXHALED BREATH CONDENSATE; FEMALE; GASTROESOPHAGEAL REFLUX; HUMAN; LOWER ESOPHAGUS SPHINCTER; MALE; NON INVASIVE PROCEDURE; SPUTUM ANALYSIS; AGED; BREATH ANALYSIS; CHEMISTRY; COMPLICATION; MIDDLE AGED; PILOT STUDY; RESPIRATORY ASPIRATION OF GASTRIC CONTENTS; SPUTUM;

ADULT; AGED; BIOMARKERS; BREATH TESTS; BRONCHIECTASIS; ESOPHAGEAL PH MONITORING; FEMALE; GASTROESOPHAGEAL REFLUX; HUMANS; MALE; MIDDLE AGED; PEPSIN A; PILOT PROJECTS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY ASPIRATION OF GASTRIC CONTENTS; SPUTUM;

EID: 84935146652     PISSN: 00201324     EISSN: 19433654     Source Type: Journal    
DOI: 10.4187/respcare.03570     Document Type: Article

References (45)

1. D'Ovidio F, Singer LG, Hadjiliadis D, Pierre A, Waddell TK, dc Perrot M. et al. Prevalence of gastroesophageal reflux in end-stage lung disease candidates for lung transplant. Ann Thorac Surg 2005; 80(4): 1254-1260.
2. Kempainen RR. Savik K, Whelan TP. Dunitz JM. Herrington CS. Billings JL. High prevalence of proximal and distal gastroesophageal reflux disease in advanced COPD. Chest 2007; 131 (6): 1666-1671.
3. Koh WJ, Lee JH. Kwon YS, Lee KS. Suh GY. Chung MP. et al. Prevalence of gastroesophageal reflux disease in patients with non-tuberculous mycobacterial lung disease. Chest 2007; 131 (6): 1825-1830.
4. Sweet MP. Patti MG. Hoopes C, Hayes SR. Gordon JA. Gastro-oesophageal reflux and aspiration in patients with advanced lung disease. Thorax 2009; 64(2): 167-173.
5. Casanova C, Baudet JS. del Valle Velasco M, Martin JM, Aguirre-Jaime A. Pablo de Torres JP. et al. Increased gastro-oesophageal reflux disease in patients with severe COPD. Fur Respir J 2004; 23(6): 841-845.
6. Lee AL. Button BM, Dcnehy L, Roberts SJ, Bamford TL, Ellis SJ, et al. Proximal and distal gastro-oesophageal reflux in chronic obstructive pulmonary disease and bronchiectasis. Respirology 2014; 19(2): 211-217.
7. Haque M. Wyeth JW, Stace NH, Talley NJ, Green R. Prevalence, severity and associated features of gastro-oesophageal reflux and dyspepsia: a population-based study. N Z Med J 2000; 113(1110): 178-181.
8. Kahrilas P, Quigley E. Clinical esophageal pH recording: a technical review for practice guideline development. Gastroenterology 1996; 110(6): 1981-1996.
9. Potluri S, Friedenberg F, Parkman HP, Chang A, MacNeal R, Manus C, et al. Comparison of a salivary/sputum pepsin assay with 24-hour esophageal ph monitoring for detection of gastric reflux into the proximal esophagus, oropharynx and lung. Dig Dis Sci 2003; 48(9): 1813-1817.
10. Ward C, Forrest A, Brownlee IA, Johnson GE, Murphy DM, Pearson JP, et al. Pepsin like activity in bronchoalveolar lavage fluid is suggestive of gastric aspiration in lung allografts. Thorax 2005; 60(10): 872-874.
11. Stovold R, Forrest IA, Corris PA. Murphy DM. Smith JA, Decalmer S. et al. Pepsin, a biomarker of gastric aspiration in lung allografts. A putative association with rejection. Am J Respir Crit Care Med 2007; 175(12): 1298-1303.
12. Starosta V, Kitz R, Hartl D, Marcos V, Reinhardt D, Gricsc M. Bronchoalveolar pepsin, bile acids, oxidation and inflammation in children with gastroesophageal reflux disease. Chest 2007; 132(5): 1557-1564.
13. Farrell S. McMaster C, Gibson D, Shields MD, McCallion WA. Pepsin in bronchoalveolar lavage fluid: a specific and sensitive method of diagnosing gastro-oesophageal reflux-related pulmonary aspiration. J Pediatr Surg 2006; 41(2): 289-293.
14. Blondeau K. Mertens V. Vanaudenaerde BA, Verlcdcn GM, Van Raemdonck DE. Sifrim D, Dupont LJ. Gastro-oesophageal reflux and gastric aspiration in lung transplant patients with or without chronic rejection. Eur Respir J 2008; 31 (4): 707-713.
15. Hunt J. Exhaled breath condensate pH: reflecting acidification of the airway at all levels. Am J Respir Crit Care Med 2006; 173(4): 366-367.
16. Hunt J. Yu Y, Burns J, Gaston B. Ngamtrakulpanit I., Bunyan D, et al. Identification of acid reflux cough using serial assays of exhaled breath condensate pH. Cough 2006; 2: 3.
17. Borrill Z. Starkey C. Vcstbo J. Singh D. Reproducibility of exhaled breath condensate pH in chronic obstructive pulmonary disease. Eur Respir J 2005; 25(2): 269-274.
18. Koczulla R. Dragonieri S, Schot R, Bals R, Gauw SA, Vogelmeier C, et al. Comparison of exhaled breath condensate pH using two commercially available devices in healthy controls, asthma and COPD patients. Respir Res 2009; 10: 78.
19. Kostikas K, Papathcodorou G, Ganas K, Psathakis K, Panagou P, Loukidcs S. pH in expired breath condensate of patients with inflammatory airway diseases. Am J Respir Crit Care Med 2002; 165(10): 1364-1370.
20. Krishnan A. Chow S. Glanville A. Thomas P. Yates D. Exhaled breath condensate pepsin before and after Nissen fundoplication: a non-invasive marker of GORD after lung transplantation? Respirology 2007; A59: TP 120.
21. Timms C, Thomas PS. Yates DH. Detection of gastro-oesophageal reflux disease (GORD) in patients with obstructive lung disease using exhaled breath profiling. J Breath Res 2012; 6(1): 016003.
22. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease (revised 2011). http: //www. goldcopd. org/uploads/users/files/GOLD_Report_201 l_Feb21 .pdf. Accessed May 20. 2014.
23. Global Initiative for Asthma. Global strategy for asthma management and prevention. http: //www. ginasthma. Org/documents/4. Accessed March /, 2013.
24. Bhalla M, Turcios N, Aponte V, Jenkins M, Lehman BS, McCauley DI, Naidich DP. Cystic fibrosis: scoring system with thin-section CT. Radiology 1991; 179(3): 783-788.
25. Naidich DP. McCauley DI. Khouri NF, Stitik FP, Siegelman SS. Computed tomography of bronchiectasis. J Comput Assist Tomogr 1982; 6(3): 437-444.
26. Wolfe MM, Sachs G. Acid suppression: optimizing therapy for gastroduodenal ulcer healing, gastroesophageal rellux disease and stress-related erosive syndrome. Gastroenterology 2000; 118(2 Suppl 1): S9-S31
27. Jamieson JR. Stein HJ, DeMcester TR, Bonavina L. Schwizcr W, Hinder RA. Albertucci M. Ambulatory 24-H esophageal pH monitoring normal values, optimal thresholds, specificity, sensitivity and reproducibility. Am J Gastroenterol 1992; 87(9): 1102-1 111.
28. Dobhan R, Castell D. Normal and abnormal proximal esophageal acid exposure: results of ambulatory dual-probe pH monitoring. Am J Gastroenterol 1993; 88(1): 25-29.
29. Carlsson R, Dent J. Bolling-Stcrnevald E, Johnsson F, Junghard O, Lauritsen K. et al. The usefulness of a structured questionnaire in the assessment of symptomatic gastroesophageal reflux disease. Scand J Gastroenterol 1998; 33(10): 1023-1031.
30. Vaughan J, Ngamtrakulpanit L, Pajewski TN, Turner R, Nguyen TA, Smith A, et al. Exhaled breath condensate pH is a robust and reproducible assay of airway acidity. Eur Respir J 2003; 22(6): 889-894.
31. Horvdth I, Hunt J, Barnes PJ, Alving K, Antczak A, Baraldi E, et al. Exhaled breath condensate. Methodological recommendations and unresolved questions. Eur Respir J 2005; 26(3): 523-548.
32. Tasker A, Dcttmar PW, Panetti M, Koufman JA, Birchall JP, Pearson JP. Reflux of gastric juice and glue ear in children. Lancet 2002; 359(9305): 493.
33. MacNce W, Rennard SI, Hunt JF, Edwards LD, Miller BE. Locantore NW, Tal-Singer R. Evaluation of exhaled breath condensate pH as a biomarkcr for COPD. Respir Med 2011; 105(7): 1037-1045.
34. Papaioannou AL Loukides S, Minas M, Kontogianni K, Bakakos P. Gourgoulianis K, et al. Exhaled breath condensate pH as a bio-marker of COPD severity in ex-smokers. Respir Res 2011; 12: 67.
35. Terada K, Muro S, Sato S, Ohara T, Haruna A, Marumo S, et al. Impact of gastro-oesophageal reflux disease symptoms on chronic obstructive pulmonary disease exacerbation. Thorax 2008; 63(11): 951-955.
36. Kadakia SC, Kikendall JW, Maydonovitch C, Johnson LF. Effect of cigarette smoking on gastroesophageal reflux measured by 24-h ambulatory esophageal pH monitoring. Am J Gastroenterol 1995; 90(10): 1785-1790.
37. Sweet MP, Herbella FA, Leard L, Hoopes C, Golden J, Hays S, Patti MG. The prevalence of distal and proximal gastroesophageal reflux in patients awaiting lung transplantation. Ann Surg 2006; 244(4): 491-497.
38. Kamble NL, Khan NN, Kumar N, Nayak HK. Daga MK. Study of gastro-oesophageal reflux disease in patients with mild-to-modcrate chronic obstructive pulmonary disease in India. Respirology 2013; 18(3): 463-467.
39. Soyer T, SoyerOU, Birben E, Kisa U, Kalayci O, Cakmak M. Pepsin levels and oxidative stress markers in exhaled breath condensate of patients with gastroesophageal reflux disease. J Pediatr Surg 2013; 48(11): 2247-2250.
40. Johnson LF, DeMeester TR. Twenty-four pH monitoring of the distal esophagus: a quantitative measure of gastroesophageal reflux. Am J Gastroenterol 1974; 62(4): 325-332.
41. Yates DH, Krishnan A, Chow S, Thomas PS. Non-invasive assessment of exhaled biomarkers in lung transplantation. J Breath Res 2011; 5(2): 024001
42. Krishnan A, Chow S. Thomas P, Malouf M, Glanvillc A, Yates D. Exhaled breath condensate pepsin: a new noninvasive marker of gastroesophageal refluxD after lung transplantation. J Heart Lung Transplant 2007; 26: S139.
43. Knight J. Lively MO. Johnston N, Dettmar PW, Koufman JA. Sensitive pepsin immunoassay for detection of laryngopharyngeal reflux. Laryngoscope 2005; 115(8): 1473-1478.
44. Mise K, Capkun V, Jurcev-Savicevic A, Sundov Z, Bradaric A, Mladinov S. The influence of gastroesophageal reflux in the lung: a case-control study. Respirology 2010: 15(5): 837-842.
45. Martinez CH, Okajima Y, Murray S, Washko GR, Martinez FJ, Silverman EK, et al. Impact of self-reported gastroesophageal reflux disease in subjects from COPDGene cohort. Respir Res 2014; 15: 62.