Pepsin in bronchoalveolar lavage fluid: A specific and sensitive method of diagnosing gastro-oesophageal reflux-related pulmonary aspiration

Journal of Pediatric Surgery

Volumn 41, Issue 2, 2006, Pages 289-293

  Farrell, Stephen ^a   McMaster, Cyril ^a   Gibson, David ^a   Shields, Michael D ^a   McCallion, William A ^b  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b ROYAL BELFAST HOSPITAL FOR SICK CHILDREN   (United Kingdom)

Author keywords

Aspiration; Children; Cough; Gastroesophageal reflux; Respiratory

Indexed keywords

LIPID; PEPSIN A;

ASPIRATION PNEUMONIA; CHILD; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; COUGHING; DIAGNOSTIC ACCURACY; ELECTIVE SURGERY; ENDOTRACHEAL INTUBATION; FEMALE; GASTROESOPHAGEAL REFLUX; HUMAN; IMMUNOASSAY; LUNG LAVAGE; MACROPHAGE; MALE; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; SENSITIVITY AND SPECIFICITY; VALIDATION PROCESS;

BRONCHOALVEOLAR LAVAGE FLUID; CHILD; CHILD, PRESCHOOL; DIAGNOSIS, DIFFERENTIAL; FEMALE; GASTROESOPHAGEAL REFLUX; HUMANS; IMMUNOASSAY; MALE; PEPSIN A; PNEUMONIA, ASPIRATION; RESPIRATION DISORDERS; SENSITIVITY AND SPECIFICITY;

EID: 32544447428     PISSN: 00223468     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2005.11.002     Document Type: Conference Paper

References (14)

1. E.W. Fonkalsrud, and M.E. Ament Gastroesophageal reflux in childhood Curr Probl Surg 33 1996 1 70
2. E.W. Fonkalsrud, J. Bustorff-Silva, and C.A. Perez Antireflux surgery in children under 3 months of age J Pediatr Surg 34 1999 527 531
3. S.J. Sontag Gastroesophageal reflux disease and asthma J Clin Gastroenterol 30 2000 S9 S30
4. J.P. Buts, C. Barudi, and D. Moulin Prevalence and treatment of silent gastro-oesophageal reflux in children with recurrent respiratory disorders Eur J Pediatr 145 1986 396 400
5. G.O. Andze, M.L. Brandt, and D. St Vil Diagnosis and treatment of gastroesophageal reflux in 500 children with respiratory symptoms: the value of pH monitoring J Pediatr Surg 26 1991 295 299
6. L.E. Mansfield, H.H. Hameister, and H.S. Spaulding The role of the vague nerve in airway narrowing caused by intraesophageal hydrochloric acid provocation and esophageal distention Ann Allergy 47 1981 431 434
7. R.W. Corwin, and R.S. Irwin The lipid-laden alveolar macrophage as a marker of aspiration in parenchymal lung disease Am Rev Respir Dis 132 1985 576 581
8. M.Y. Kazachkov, M.S. Muhlebach, and C.A. Livasy Lipid-laden macrophage index and inflammation in bronchoalveolar lavage fluids in children Eur Respir J 18 2001 790 795
9. U. Krishnan, J.D. Mitchell, and V. Tobias Fat laden macrophages in tracheal aspirates as a marker of reflux aspiration: a negative report J Pediatr Gastroenterol Nutr 35 2002 309 313
10. S. Knauer-Fischer, and F. Ratjen Lipid-laden macrophages in bronchoalveolar lavage fluid as a marker for pulmonary aspiration Pediatr Pulmonol 27 1999 419 422
11. D.W. Moote, D.A. Lloyd, and D.R. McCourtie Increase in gastroesophageal reflux during methacholine-induced bronchospasm J Allergy Clin Immunol 78 1986 619 623
12. R. Adams, R. Ruffin, and D. Campbell The value of the lipid-laden macrophage index in the assessment of aspiration pneumonia Aust NZ J Med 27 1997 550 553
13. M.M. Badellino, R.F. Buckman Jr., and P.J. Malaspina Detection of pulmonary aspiration of gastric contents in an animal model by assay of peptic activity in bronchoalveolar fluid Crit Care Med 24 1996 1881 1885
14. A. Tasker, P.W. Dettmar, and M. Panetti Is gastric reflux a cause of otitis media with effusion in children? Laryngoscope 112 2002 1930 1934