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Volumn 143, Issue 5, 2015, Pages 517-529

Conditioned deletion of ephrinB1 and/or ephrinB2 in either thymocytes or thymic epithelial cells alters the organization of thymic medulla and favors the appearance of thymic epithelial cysts

Author keywords

Cysts; Eph ephrin; Medulla; Thymic epithelial cells

Indexed keywords

EFNB1 PROTEIN, MOUSE; EFNB2 PROTEIN, MOUSE; EPHRIN B1; EPHRIN B2;

EID: 84935097657     PISSN: 09486143     EISSN: 1432119X     Source Type: Journal    
DOI: 10.1007/s00418-014-1296-9     Document Type: Article
Times cited : (10)

References (45)
  • 2
    • 84872172303 scopus 로고    scopus 로고
    • TNF receptor family signaling in the development and functions of medullary thymic epithelial cells
    • PID: 22969770
    • Akiyama T, Shinzawa M, Akiyama N (2012) TNF receptor family signaling in the development and functions of medullary thymic epithelial cells. Front Immunol 3:278
    • (2012) Front Immunol , vol.3 , pp. 278
    • Akiyama, T.1    Shinzawa, M.2    Akiyama, N.3
  • 5
    • 84861656218 scopus 로고    scopus 로고
    • Thymic epithelial cells: working class heroes for T cell development and repertoire selection
    • COI: 1:CAS:528:DC%2BC38XmvFKgs78%3D, PID: 22591984
    • Anderson G, Takahama Y (2012) Thymic epithelial cells: working class heroes for T cell development and repertoire selection. Trends Immunol 33:256–263
    • (2012) Trends Immunol , vol.33 , pp. 256-263
    • Anderson, G.1    Takahama, Y.2
  • 7
    • 84874962972 scopus 로고    scopus 로고
    • Generation of both cortical and Aire(+) medullary thymic epithelial compartments from CD205(+) progenitors
    • COI: 1:CAS:528:DC%2BC3sXit1Kgur8%3D, PID: 23299414
    • Baik S, Jenkinson EJ, Lane PJ, Anderson G, Jenkinson WE (2013) Generation of both cortical and Aire(+) medullary thymic epithelial compartments from CD205(+) progenitors. Eur J Immunol 43:589–594
    • (2013) Eur J Immunol , vol.43 , pp. 589-594
    • Baik, S.1    Jenkinson, E.J.2    Lane, P.J.3    Anderson, G.4    Jenkinson, W.E.5
  • 8
    • 10944269361 scopus 로고    scopus 로고
    • Homing of immature thymocytes to the subcapsular microenvironment within the thymus is not an absolute requirement for T cell development
    • COI: 1:CAS:528:DC%2BD2cXhtFajtrvO, PID: 15484191
    • Benz C, Heinzel K, Bleul CC (2004) Homing of immature thymocytes to the subcapsular microenvironment within the thymus is not an absolute requirement for T cell development. Eur J Immunol 34:3652–3663
    • (2004) Eur J Immunol , vol.34 , pp. 3652-3663
    • Benz, C.1    Heinzel, K.2    Bleul, C.C.3
  • 9
    • 84859208234 scopus 로고    scopus 로고
    • Synergistic, context-dependent, and hierarchical functions of epithelial components in thymic microenvironments
    • COI: 1:CAS:528:DC%2BC38XltVejs70%3D, PID: 22464328
    • Calderon L, Boehm T (2012) Synergistic, context-dependent, and hierarchical functions of epithelial components in thymic microenvironments. Cell 149:159–172
    • (2012) Cell , vol.149 , pp. 159-172
    • Calderon, L.1    Boehm, T.2
  • 10
    • 84874923547 scopus 로고    scopus 로고
    • Ephrin-B-dependent thymic epithelial cell-thymocyte interactions are necessary for correct T cell differentiation and thymus histology organization: relevance for thymic cortex development
    • COI: 1:CAS:528:DC%2BC3sXjsFGqtb8%3D, PID: 23408838
    • Cejalvo T, Munoz JJ, Tobajas E, Fanlo L, Alfaro D, Garcia-Ceca J, Zapata A (2013) Ephrin-B-dependent thymic epithelial cell-thymocyte interactions are necessary for correct T cell differentiation and thymus histology organization: relevance for thymic cortex development. J Immunol 190:2670–2681
    • (2013) J Immunol , vol.190 , pp. 2670-2681
    • Cejalvo, T.1    Munoz, J.J.2    Tobajas, E.3    Fanlo, L.4    Alfaro, D.5    Garcia-Ceca, J.6    Zapata, A.7
  • 12
    • 1642273208 scopus 로고    scopus 로고
    • Ephrin-B1 forward and reverse signaling are required during mouse development
    • COI: 1:CAS:528:DC%2BD2cXis1KnsLs%3D, PID: 15037550
    • Davy A, Aubin J, Soriano P (2004) Ephrin-B1 forward and reverse signaling are required during mouse development. Genes Dev 18:572–583
    • (2004) Genes Dev , vol.18 , pp. 572-583
    • Davy, A.1    Aubin, J.2    Soriano, P.3
  • 13
    • 84871127197 scopus 로고    scopus 로고
    • Developmentally regulated availability of RANKL and CD40 ligand reveals distinct mechanisms of fetal and adult cross-talk in the thymus medulla
    • COI: 1:CAS:528:DC%2BC38Xhsl2jtLfL, PID: 23152561
    • Desanti GE, Cowan JE, Baik S, Parnell SM, White AJ, Penninger JM, Lane PJ, Jenkinson EJ, Jenkinson WE, Anderson G (2012) Developmentally regulated availability of RANKL and CD40 ligand reveals distinct mechanisms of fetal and adult cross-talk in the thymus medulla. J Immunol 189:5519–5526
    • (2012) J Immunol , vol.189 , pp. 5519-5526
    • Desanti, G.E.1    Cowan, J.E.2    Baik, S.3    Parnell, S.M.4    White, A.J.5    Penninger, J.M.6    Lane, P.J.7    Jenkinson, E.J.8    Jenkinson, W.E.9    Anderson, G.10
  • 14
    • 0036864744 scopus 로고    scopus 로고
    • Organization of thymic medullary epithelial heterogeneity: implications for mechanisms of epithelial differentiation
    • COI: 1:CAS:528:DC%2BD38XpslertL0%3D, PID: 12445262
    • Farr AG, Dooley JL, Erickson M (2002) Organization of thymic medullary epithelial heterogeneity: implications for mechanisms of epithelial differentiation. Immunol Rev 189:20–27
    • (2002) Immunol Rev , vol.189 , pp. 20-27
    • Farr, A.G.1    Dooley, J.L.2    Erickson, M.3
  • 15
    • 17144363197 scopus 로고    scopus 로고
    • Reconstruct: a free editor for serial section microscopy
    • COI: 1:STN:280:DC%2BD2M7osV2msQ%3D%3D, PID: 15817063
    • Fiala JC (2005) Reconstruct: a free editor for serial section microscopy. J Microsc 218:52–61
    • (2005) J Microsc , vol.218 , pp. 52-61
    • Fiala, J.C.1
  • 16
    • 70350034156 scopus 로고    scopus 로고
    • On the role of Eph signalling in thymus histogenesis; EphB2/B3 and the organizing of the thymic epithelial network
    • COI: 1:CAS:528:DC%2BD1MXht12htb%2FI, PID: 19598115
    • Garcia-Ceca J, Jimenez E, Alfaro D, Cejalvo T, Chumley MJ, Henkemeyer M, Munoz JJ, Zapata AG (2009a) On the role of Eph signalling in thymus histogenesis; EphB2/B3 and the organizing of the thymic epithelial network. Int J Dev Biol 53:971–982
    • (2009) Int J Dev Biol , vol.53 , pp. 971-982
    • Garcia-Ceca, J.1    Jimenez, E.2    Alfaro, D.3    Cejalvo, T.4    Chumley, M.J.5    Henkemeyer, M.6    Munoz, J.J.7    Zapata, A.G.8
  • 17
    • 70350524987 scopus 로고    scopus 로고
    • Cell-autonomous role of EphB2 and EphB3 receptors in the thymic epithelial cell organization
    • COI: 1:CAS:528:DC%2BD1MXht1amurnE, PID: 19731361
    • Garcia-Ceca J, Jimenez E, Alfaro D, Cejalvo T, Munoz JJ, Zapata AG (2009b) Cell-autonomous role of EphB2 and EphB3 receptors in the thymic epithelial cell organization. Eur J Immunol 39:2916–2924
    • (2009) Eur J Immunol , vol.39 , pp. 2916-2924
    • Garcia-Ceca, J.1    Jimenez, E.2    Alfaro, D.3    Cejalvo, T.4    Munoz, J.J.5    Zapata, A.G.6
  • 18
    • 0041819789 scopus 로고    scopus 로고
    • Development of thymic microenvironments in vitro is oxygen-dependent and requires permanent presence of T-cell progenitors
    • COI: 1:CAS:528:DC%2BD3sXntFentbY%3D, PID: 12923248
    • Germeraad WT, Kawamoto H, Itoi M, Jiang Y, Amagai T, Katsura Y, van Ewijk W (2003) Development of thymic microenvironments in vitro is oxygen-dependent and requires permanent presence of T-cell progenitors. J Histochem Cytochem 51:1225–1235
    • (2003) J Histochem Cytochem , vol.51 , pp. 1225-1235
    • Germeraad, W.T.1    Kawamoto, H.2    Itoi, M.3    Jiang, Y.4    Amagai, T.5    Katsura, Y.6    van Ewijk, W.7
  • 19
    • 33845239216 scopus 로고    scopus 로고
    • Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells
    • COI: 1:CAS:528:DC%2BD28Xht1Kgs7zJ, PID: 16896157
    • Gray DH, Seach N, Ueno T, Milton MK, Liston A, Lew AM, Goodnow CC, Boyd RL (2006) Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells. Blood 108:3777–3785
    • (2006) Blood , vol.108 , pp. 3777-3785
    • Gray, D.H.1    Seach, N.2    Ueno, T.3    Milton, M.K.4    Liston, A.5    Lew, A.M.6    Goodnow, C.C.7    Boyd, R.L.8
  • 20
    • 79955780659 scopus 로고    scopus 로고
    • Morphogenesis and maintenance of the 3D thymic medulla and prevention of nude skin phenotype require FoxN1 in pre- and post-natal K14 epithelium
    • COI: 1:CAS:528:DC%2BC3MXitlaqtr0%3D, PID: 21109991
    • Guo J, Rahman M, Cheng L, Zhang S, Tvinnereim A, Su DM (2011) Morphogenesis and maintenance of the 3D thymic medulla and prevention of nude skin phenotype require FoxN1 in pre- and post-natal K14 epithelium. J Mol Med 89(3):263–277
    • (2011) J Mol Med , vol.89 , Issue.3 , pp. 263-277
    • Guo, J.1    Rahman, M.2    Cheng, L.3    Zhang, S.4    Tvinnereim, A.5    Su, D.M.6
  • 21
    • 34247868281 scopus 로고    scopus 로고
    • Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin
    • COI: 1:CAS:528:DC%2BD2sXhslWmsrY%3D, PID: 17277780
    • Hamazaki Y, Fujita H, Kobayashi T, Choi Y, Scott HS, Matsumoto M, Minato N (2007) Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin. Nat Immunol 8:304–311
    • (2007) Nat Immunol , vol.8 , pp. 304-311
    • Hamazaki, Y.1    Fujita, H.2    Kobayashi, T.3    Choi, Y.4    Scott, H.S.5    Matsumoto, M.6    Minato, N.7
  • 24
    • 83655197143 scopus 로고    scopus 로고
    • The effect of conditional EFNB1 deletion in the T cell compartment on T cell development and function
    • COI: 1:CAS:528:DC%2BC38Xkslagt7g%3D, PID: 22182253
    • Jin W, Qi S, Luo H (2011) The effect of conditional EFNB1 deletion in the T cell compartment on T cell development and function. BMC Immunol 12:68
    • (2011) BMC Immunol , vol.12 , pp. 68
    • Jin, W.1    Qi, S.2    Luo, H.3
  • 25
    • 84861757370 scopus 로고    scopus 로고
    • T cell-specific deletion of EFNB2 minimally affects T cell development and function
    • COI: 1:CAS:528:DC%2BC38XhtVOisrbF, PID: 22673212
    • Jin W, Qi S, Luo H (2012) T cell-specific deletion of EFNB2 minimally affects T cell development and function. Mol Immunol 52:141–147
    • (2012) Mol Immunol , vol.52 , pp. 141-147
    • Jin, W.1    Qi, S.2    Luo, H.3
  • 26
    • 84887598220 scopus 로고    scopus 로고
    • Effect of reduced EPHB4 expression in thymic epithelial cells on thymocyte development and peripheral T cell function
    • COI: 1:CAS:528:DC%2BC2cXis1Cluw%3D%3D, PID: 24246266
    • Jin W, Luo H, Wu J (2014) Effect of reduced EPHB4 expression in thymic epithelial cells on thymocyte development and peripheral T cell function. Mol Immunol 58:1–9
    • (2014) Mol Immunol , vol.58 , pp. 1-9
    • Jin, W.1    Luo, H.2    Wu, J.3
  • 27
    • 0037105620 scopus 로고    scopus 로고
    • Cutting edge: thymocyte-independent and thymocyte-dependent phases of epithelial patterning in the fetal thymus
    • COI: 1:CAS:528:DC%2BD38XntFaht78%3D, PID: 12218095
    • Klug DB, Carter C, Gimenez-Conti IB, Richie ER (2002) Cutting edge: thymocyte-independent and thymocyte-dependent phases of epithelial patterning in the fetal thymus. J Immunol 169:2842–2845
    • (2002) J Immunol , vol.169 , pp. 2842-2845
    • Klug, D.B.1    Carter, C.2    Gimenez-Conti, I.B.3    Richie, E.R.4
  • 28
    • 85047689975 scopus 로고    scopus 로고
    • EphB6-null mutation results in compromised T cell function
    • COI: 1:CAS:528:DC%2BD2cXhtFaiur%2FN, PID: 15599401
    • Luo H, Yu G, Tremblay J, Wu J (2004) EphB6-null mutation results in compromised T cell function. J Clin Invest 114:1762–1773
    • (2004) J Clin Invest , vol.114 , pp. 1762-1773
    • Luo, H.1    Yu, G.2    Tremblay, J.3    Wu, J.4
  • 29
    • 84455192589 scopus 로고    scopus 로고
    • Ephrinb1 and Ephrinb2 are associated with interleukin-7 receptor alpha and retard its internalization from the cell surface
    • COI: 1:CAS:528:DC%2BC3MXhs1Ois7fE, PID: 22069310
    • Luo H, Wu Z, Qi S, Jin W, Han B, Wu J (2011) Ephrinb1 and Ephrinb2 are associated with interleukin-7 receptor alpha and retard its internalization from the cell surface. J Biol Chem 286:44976–44987
    • (2011) J Biol Chem , vol.286 , pp. 44976-44987
    • Luo, H.1    Wu, Z.2    Qi, S.3    Jin, W.4    Han, B.5    Wu, J.6
  • 33
  • 34
    • 0027758094 scopus 로고
    • Expression of the alpha beta T-cell receptor is necessary for the generation of the thymic medulla
    • COI: 1:STN:280:DyaK2c7gvVamsQ%3D%3D, PID: 8281032
    • Palmer DB, Viney JL, Ritter MA, Hayday AC, Owen MJ (1993) Expression of the alpha beta T-cell receptor is necessary for the generation of the thymic medulla. Dev Immunol 3:175–179
    • (1993) Dev Immunol , vol.3 , pp. 175-179
    • Palmer, D.B.1    Viney, J.L.2    Ritter, M.A.3    Hayday, A.C.4    Owen, M.J.5
  • 35
    • 20344396123 scopus 로고    scopus 로고
    • Eph receptor signalling casts a wide net on cell behaviour
    • COI: 1:CAS:528:DC%2BD2MXks1Gmtbs%3D, PID: 15928710
    • Pasquale EB (2005) Eph receptor signalling casts a wide net on cell behaviour. Nat Rev Mol Cell Biol 6:462–475
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 462-475
    • Pasquale, E.B.1
  • 36
    • 5044240692 scopus 로고    scopus 로고
    • Diverse roles of eph receptors and ephrins in the regulation of cell migration and tissue assembly
    • COI: 1:CAS:528:DC%2BD2cXptlGjtLY%3D, PID: 15469835
    • Poliakov A, Cotrina M, Wilkinson DG (2004) Diverse roles of eph receptors and ephrins in the regulation of cell migration and tissue assembly. Dev Cell 7:465–480
    • (2004) Dev Cell , vol.7 , pp. 465-480
    • Poliakov, A.1    Cotrina, M.2    Wilkinson, D.G.3
  • 37
    • 0035881543 scopus 로고    scopus 로고
    • Development of the thymus requires signaling through the fibroblast growth factor receptor R2-IIIb
    • COI: 1:CAS:528:DC%2BD3MXlvFeqtLk%3D, PID: 11489975
    • Revest JM, Suniara RK, Kerr K, Owen JJ, Dickson C (2001) Development of the thymus requires signaling through the fibroblast growth factor receptor R2-IIIb. J Immunol 167:1954–1961
    • (2001) J Immunol , vol.167 , pp. 1954-1961
    • Revest, J.M.1    Suniara, R.K.2    Kerr, K.3    Owen, J.J.4    Dickson, C.5
  • 38
    • 84880685834 scopus 로고    scopus 로고
    • Thymocyte selection regulates the homeostasis of IL-7-expressing thymic cortical epithelial cells in vivo
    • Ribeiro AR, Rodrigues PM, Meireles C, Di Santo JP, Alves NL (2014) Thymocyte selection regulates the homeostasis of IL-7-expressing thymic cortical epithelial cells in vivo. J Immunol 191:1200–1209
    • (2014) J Immunol , vol.191 , pp. 1200-1209
    • Ribeiro, A.R.1    Rodrigues, P.M.2    Meireles, C.3    Di Santo, J.P.4    Alves, N.L.5
  • 40
    • 0034868746 scopus 로고    scopus 로고
    • Stat3 in thymic epithelial cells is essential for postnatal maintenance of thymic architecture and thymocyte survival
    • COI: 1:CAS:528:DC%2BD3MXmsF2itr0%3D, PID: 11520461
    • Sano S, Takahama Y, Sugawara T, Kosaka H, Itami S, Yoshikawa K, Miyazaki J, van Ewijk W, Takeda J (2001) Stat3 in thymic epithelial cells is essential for postnatal maintenance of thymic architecture and thymocyte survival. Immunity 15:261–273
    • (2001) Immunity , vol.15 , pp. 261-273
    • Sano, S.1    Takahama, Y.2    Sugawara, T.3    Kosaka, H.4    Itami, S.5    Yoshikawa, K.6    Miyazaki, J.7    van Ewijk, W.8    Takeda, J.9
  • 42
    • 0027956747 scopus 로고
    • Maturation of medullary thymic epithelium requires thymocytes expressing fully assembled CD3-TCR complexes
    • COI: 1:CAS:528:DyaK2MXitFClsr0%3D, PID: 7819148
    • Shores EW, Van Ewijk W, Singer A (1994) Maturation of medullary thymic epithelium requires thymocytes expressing fully assembled CD3-TCR complexes. Int Immunol 6:1393–1402
    • (1994) Int Immunol , vol.6 , pp. 1393-1402
    • Shores, E.W.1    Van Ewijk, W.2    Singer, A.3


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