Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers

Science

Volumn 349, Issue 6243, 2015, Pages 88-91

  Fibriansah, Guntur ^a,b   Ibarra, Kristie D ^c   Ng, Thiam Seng ^a,b   Smith, Scott A ^d,e   Tan, Joanne L ^a,b   Lim, Xin Ni ^a,b   Ooi, Justin S G ^a,b   Kostyuchenko, Victor A ^a,b   Wang, Jiaqi ^a,b   De Silva, Aravinda M ^f   Harris, Eva ^c   Crowe, James E ^e,g   Lok, Shee Mei ^a,b  

^a DUKE NUS MEDICAL SCHOOL   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d VANDERBILT UNIVERSITY   (United States)

^e VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^f UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^g VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIMER; E PROTEIN; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG; VIRUS PROTEIN; EPITOPE; NEUTRALIZING ANTIBODY; VIRUS ENVELOPE PROTEIN;

ANTIBODY; CRYOBIOLOGY; DENGUE FEVER; DISEASE TREATMENT; ELECTRON MICROSCOPY; INFECTIVITY; MOLECULAR ANALYSIS; PROTEIN; RODENT; VACCINE; VIRUS;

ARTICLE; CONTROLLED STUDY; CRYOELECTRON MICROSCOPY; DENGUE; DENGUE VIRUS 2; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; SECONDARY INFECTION; VIRUS PARTICLE; ANIMAL; CROSS REACTION; DENGUE VIRUS; DISEASE MODEL; HUMAN; IMMUNOLOGY; MIXED INFECTION; MOUSE; SEROTYPE; ULTRASTRUCTURE;

DENGUE VIRUS; DENGUE VIRUS TYPE 2;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; COINFECTION; CROSS REACTIONS; CRYOELECTRON MICROSCOPY; DENGUE VIRUS; DISEASE MODELS, ANIMAL; EPITOPES; HUMANS; MICE; SEROGROUP; VIRAL ENVELOPE PROTEINS;

EID: 84935097021     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaa8651     Document Type: Article

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