A randomised trial of granulocyte-macrophage colony-stimulating factor for neonatal sepsis: Childhood outcomes at 5 years

Archives of Disease in Childhood: Fetal and Neonatal Edition

Volumn 100, Issue 4, 2015, Pages F320-F326

  Marlow, Neil ^a   Morris, Timothy ^a   Brocklehurst, Peter ^a   Carr, Robert ^b   Cowan, Frances ^c   Patel, Nishma ^a   Petrou, Stavros ^d   Redshaw, Margaret ^e   Modi, Neena ^c   Doré, Caroline J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF WARWICK   (United Kingdom)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEMATOLOGIC AGENT;

ACADEMIC ACHIEVEMENT; ARTICLE; CHILD; CHILDHOOD; CONTROLLED STUDY; FOLLOW UP; HEALTH STATUS; HUMAN; MAJOR CLINICAL STUDY; NERVE CELL DIFFERENTIATION; NEWBORN SEPSIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; BLOOD; CHILD DEVELOPMENT; DRUG EFFECTS; FEMALE; GROWTH, DEVELOPMENT AND AGING; LEUKOCYTE COUNT; MALE; NEUROPSYCHOLOGICAL TEST; NEUTROPHIL; NEWBORN; OUTCOME ASSESSMENT; PREMATURITY; SEPSIS; SMALL FOR DATE INFANT; TIME;

CHILD DEVELOPMENT; FEMALE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HEMATOLOGIC AGENTS; HUMANS; INFANT, EXTREMELY PREMATURE; INFANT, NEWBORN; INFANT, SMALL FOR GESTATIONAL AGE; LEUKOCYTE COUNT; MALE; NEUROPSYCHOLOGICAL TESTS; NEUTROPHILS; OUTCOME ASSESSMENT (HEALTH CARE); SEPSIS; TIME;

EID: 84935085313     PISSN: 13592998     EISSN: 14682052     Source Type: Journal    
DOI: 10.1136/archdischild-2014-307410     Document Type: Article

References (27)

1. Dammann O, Leviton A. Infection remote from the brain, neonatal white matter damage, and cerebral palsy in the preterm infant. Semin Pediatr Neurol 1998;5:190-201.
2. Volpe JJ. Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. Lancet Neurol 2009;8:110-24.
3. Sung L, Nathan PC, Lange B, et al. Prophylactic granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor decrease febrile neutropenia after chemotherapy in children with cancer: a meta-analysis of randomized controlled trials. J Clin Oncol 2004;22:3350-6.
4. Carr R, Brocklehurst P, Dore CJ, et al. Granulocyte-macrophage colony stimulating factor administered as prophylaxis for reduction of sepsis in extremely preterm, small for gestational age neonates (the PROGRAMS trial): a single-blind, multicentre, randomised controlled trial. Lancet 2009;373:226-33.
5. Carr R, Modi N, Dore C. G-CSF and GM-CSF for treating or preventing neonatal infections. Cochrane Database Syst Rev 2003;(3):CD003066.
6. Marlow N, Morris T, Brocklehurst P, et al. A randomised trial of granulocyte-macrophage colony-stimulating factor for neonatal sepsis: outcomes at 2 years. Arch Dis Child Fetal Neonatal Ed 2013;98:F46-53.
7. Kaufman A, Kaufman N. Kaufman Assessment Battery for Children (K-ABC). Circle Pines, Minnesota: American Guidance Service, 1983.
8. Korkman M, Kirk U, Kemp S. Manual for the NEPSY: a developmental neuropsychological assessment. San Antonio, Texas: Psychological Testing Corporation, 1998.
9. Edmondson L. Interpreting and using the new UK-WHO Growth Standards. J Fam Health Care 2009;19:206-9.
10. Colledge E, Bishop DV, Koeppen-Schomerus G, et al. The structure of language abilities at 4 years: a twin study. Dev Psychol 2002;38:749-57.
11. Asher MI, Keil U, Anderson HR, et al. International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods. Eur Respir J 1995;8:483-91.
12. Schulz KF, Altman DG, Moher D, et al. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. BMJ 2010;340:c332.
13. Altman DG, Machin D, Bryant TN, et al. Statistics with confidence 2E. Oxford: Wiley-Blackwell, 2000.
14. Noble M, McLennan D, Wilkinson K, et al. The English indices of deprivation 2007. London: Department for Communities and Local Government. HMSO, 2008.
15. Wolke D, Sohne B, Ohrt B, et al. Follow-up of preterm children: important to document dropouts. Lancet 1995;345:447.
16. Tin W, Fritz S, Wariyar U, et al. Outcome of very preterm birth: children reviewed with ease at 2 years differ from those followed up with difficulty. Arch Dis Child Fetal Neonatal Ed 1998;79:F83-7.
17. Flynn JR. Israeli military IQ tests: gender differences small; IQ gains large. J Biosoc Sci 1998;30:541-53.
18. Marlow N, Wolke D, Bracewell MA, et al. Neurologic and developmental disability at six years of age after extremely preterm birth. N Engl J Med 2005;352:9-19.
19. Morsing E, Asard M, Ley D, et al. Cognitive function after intrauterine growth restriction and very preterm birth. Pediatrics 2011;127:e874-82.
20. Wood NS, Marlow N, Costeloe K, et al. Neurologic and developmental disability after extremely preterm birth. EPICure Study Group. N Engl J Med 2000;343:378-84.
21. MacKay DF, Smith GC, Dobbie R, et al. Gestational age at delivery and special educational need: retrospective cohort study of 407,503 schoolchildren. PLoS Med 2010;7:e1000289.
22. Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am J Respir Crit Care Med 2001;163:1723-9.
23. Brodszki J, Morsing E, Malcus P, et al. Early intervention in management of very preterm growth-restricted fetuses: 2-year outcome of infants delivered on fetal indication before 30 gestational weeks. Ultrasound Obstet Gynecol 2009;34:288-96.
24. Groneck P, Speer CP. Inflammatory mediators and bronchopulmonary dysplasia. Arch Dis Child Fetal Neonatal Ed 1995;73:F1-3.
25. Carr R, Modi N. Haemopoietic colony stimulating factors for preterm neonates. Arch Dis Child Fetal Neonatal Ed 1997;76:F128-33.
26. Rosenthal J, Healey T, Ellis R, et al. A two-year follow-up of neonates with presumed sepsis treated with recombinant human granulocyte colony-stimulating factor during the first week of life. J Pediatr 1996;128:135-7.
27. Carlsson G, Andersson M, Putsep K, et al. Kostmann syndrome or infantile genetic agranulocytosis, part one: celebrating 50 years of clinical and basic research on severe congenital neutropenia. Acta Paediatr 2006;95:1526-32.