메뉴 건너뛰기




Volumn 10, Issue 6, 2015, Pages

Association of adiponectin gene polymorphism with nonalcoholic fatty liver disease in Taiwanese patients with type 2 diabetes

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; ADIPOQ PROTEIN, HUMAN;

EID: 84934995567     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0127521     Document Type: Article
Times cited : (21)

References (37)
  • 1
    • 84863148823 scopus 로고    scopus 로고
    • Natural course of nonalcoholic fatty liver disease in southern China: A prospectivecohort study
    • PMID: 22356310
    • Zhou YJ, Li YY, Nie YQ, Huang CM, Cao CY. Natural course of nonalcoholic fatty liver disease in southern China: a prospectivecohort study. J Dig Dis. 2012; 13: 153-160. doi: 10.1111/j.1751-2980.2011.00571.x PMID: 22356310
    • (2012) J Dig Dis. , vol.13 , pp. 153-160
    • Zhou, Y.J.1    Li, Y.Y.2    Nie, Y.Q.3    Huang, C.M.4    Cao, C.Y.5
  • 2
    • 84859448472 scopus 로고    scopus 로고
    • Metabolic syndrome and risk factors for non-alcoholic fatty liver disease
    • PMID: 22481692
    • Souza MR, Diniz Mde F, Medeiros-Filho JE, Araújo MS. Metabolic syndrome and risk factors for non-alcoholic fatty liver disease. Arq Gastroenterol. 2012; 49: 89-96. PMID: 22481692
    • (2012) Arq Gastroenterol. , vol.49 , pp. 89-96
    • Souza, M.R.1    Diniz Mde, F.2    Medeiros-Filho, J.E.3    Araújo, M.S.4
  • 3
    • 84878630492 scopus 로고    scopus 로고
    • Cardiac structure and function are altered in adults with non-alcoholic fatty liver disease
    • PMID: 23178979
    • Hallsworth K, Hollingsworth KG, Thoma C, Jakovljevic D, MacGowan GA, Anstee QM, Tet al. Cardiac structure and function are altered in adults with non-alcoholic fatty liver disease. J Hepatol. 2013; 58: 757-762. doi: 10.1016/j.jhep.2012.11.015 PMID: 23178979
    • (2013) J Hepatol. , vol.58 , pp. 757-762
    • Hallsworth, K.1    Hollingsworth, K.G.2    Thoma, C.3    Jakovljevic, D.4    MacGowan, G.A.5    Anstee, Q.M.6    Al, T.7
  • 4
    • 34547964678 scopus 로고    scopus 로고
    • Prevalence and etiology of elevated serum alanine aminotransferase level in an adult population in Taiwan
    • PMID: 17716352
    • Chen CH, Huang MH, Yang JC, Nien CK, Yang CC, Yeh YH, et al. Prevalence and etiology of elevated serum alanine aminotransferase level in an adult population in Taiwan. J Gastroenterol Hepatol. 2007; 22: 1482-1489. PMID: 17716352
    • (2007) J Gastroenterol Hepatol. , vol.22 , pp. 1482-1489
    • Chen, C.H.1    Huang, M.H.2    Yang, J.C.3    Nien, C.K.4    Yang, C.C.5    Yeh, Y.H.6
  • 5
    • 35848932768 scopus 로고    scopus 로고
    • Prevalence of non-alcoholic fatty liver disease:Population based study
    • PMID: 17786142
    • Amarapurkar D, Kamani P, Patel N, Gupte P, Kumar P, Agal S, et al. Prevalence of non-alcoholic fatty liver disease: population based study. Ann Hepatol. 2007; 6: 161-163. PMID: 17786142
    • (2007) Ann Hepatol. , vol.6 , pp. 161-163
    • Amarapurkar, D.1    Kamani, P.2    Patel, N.3    Gupte, P.4    Kumar, P.5    Agal, S.6
  • 7
    • 57749183469 scopus 로고    scopus 로고
    • Prevalence and associated factors of non-alcoholic fatty liver disease in patients with type-2 diabetes mellitus
    • PMID: 18384521
    • Leite NC, Salles GF, Araujo AL, Villela-Nogueira CA, Cardoso CR. Prevalence and associated factors of non-alcoholic fatty liver disease in patients with type-2 diabetes mellitus Liver Int. 2009; 29:113-119. doi: 10.1111/j.1478-3231.2008.01718.x PMID: 18384521
    • (2009) Liver Int. , vol.29 , pp. 113-119
    • Leite, N.C.1    Salles, G.F.2    Araujo, A.L.3    Villela-Nogueira, C.A.4    Cardoso, C.R.5
  • 8
    • 84880025806 scopus 로고    scopus 로고
    • Emergence of non-alcoholic fatty liver disease (NAFLD)
    • PMID: 24772745
    • Tandon RK. Emergence of non-alcoholic fatty liver disease (NAFLD). J Assoc Physicians India. 2013; 61: 445-446. PMID: 24772745
    • (2013) J Assoc Physicians India. , vol.61 , pp. 445-446
    • Tandon, R.K.1
  • 9
    • 84859048319 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease is associated with left ventricular diastolic dysfunction in patients with type 2 diabetes
    • PMID: 22210573
    • Bonapace S, Perseghin G, Molon G, Canali G, Bertolini L, Zoppini G, et al. Nonalcoholic fatty liver disease is associated with left ventricular diastolic dysfunction in patients with type 2 diabetes. Diabetes Care 2012; 35: 389-395. doi: 10.2337/dc11-1820 PMID: 22210573
    • (2012) Diabetes Care , vol.35 , pp. 389-395
    • Bonapace, S.1    Perseghin, G.2    Molon, G.3    Canali, G.4    Bertolini, L.5    Zoppini, G.6
  • 10
    • 84895526205 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease is associated with aortic valve sclerosis in patients with type 2 diabetes mellitus
    • Bonapace S, Valbusa F, Bertolini L, Pichiri I, Mantovani A, Rossi A, et al. Nonalcoholic fatty liver disease is associated with aortic valve sclerosis in patients with type 2 diabetes mellitus. PLoS One. 2014 5; 9: e88371.
    • (2014) PLoS One , vol.5 , Issue.9
    • Bonapace, S.1    Valbusa, F.2    Bertolini, L.3    Pichiri, I.4    Mantovani, A.5    Rossi, A.6
  • 11
    • 22344452893 scopus 로고    scopus 로고
    • The natural history of nonalcoholic fatty liver disease: A population-based cohort study
    • PMID: 15628891
    • Adams LA, Lymp JF, Sauver J St, Sanderson SO, Lindor KD, Feldstein A, et al. The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology. 2005; 129: 113-121. PMID: 15628891
    • (2005) Gastroenterology. , vol.129 , pp. 113-121
    • Adams, L.A.1    Lymp, J.F.2    Sauver3    Sanderson, S.O.4    Lindor, K.D.5    Feldstein, A.6
  • 12
    • 84873909398 scopus 로고    scopus 로고
    • Genetic and epigenetic variants influencing the development of nonalcoholic fatty liver disease
    • PMID: 23236228
    • Li YY. Genetic and epigenetic variants influencing the development of nonalcoholic fatty liver disease. World J Gastroenterol. 2012; 18: 6546-6551 doi: 10.3748/wjg.v18.i45.6546 PMID: 23236228
    • (2012) World J Gastroenterol. , vol.18 , pp. 6546-6551
    • Li, Y.Y.1
  • 13
    • 58849143075 scopus 로고    scopus 로고
    • Polymorphism of human leptin receptor gene is associated with type 2 diabetic patients complicated with non-alcoholic fatty liver disease in China
    • Lu H, Sun J, Sun L, Shu X, Xu Y, Xie D. Polymorphism of human leptin receptor gene is associated with type 2 diabetic patients complicated with non-alcoholic fatty liver disease in China. J Gastroenterol Hepatol. 2009; 24: 228-32
    • (2009) J Gastroenterol Hepatol. , vol.24 , pp. 228-232
    • Lu, H.1    Sun, J.2    Sun, L.3    Shu, X.4    Xu, Y.5    Xie, D.6
  • 14
    • 84876982317 scopus 로고    scopus 로고
    • Impact of leptin receptor gene variants on risk of non-alcoholic fatty liver disease and its interaction with adiponutrin gene
    • PMID: 23278404
    • Zain SM, Mohamed Z, Mahadeva S, Cheah PL, Rampal S, Chin KF, et al. Impact of leptin receptor gene variants on risk of non-alcoholic fatty liver disease and its interaction with adiponutrin gene. J Gastroenterol Hepatol. 2013; 28: 873-879. doi: 10.1111/jgh.12104 PMID: 23278404
    • (2013) J Gastroenterol Hepatol. , vol.28 , pp. 873-879
    • Zain, S.M.1    Mohamed, Z.2    Mahadeva, S.3    Cheah, P.L.4    Rampal, S.5    Chin, K.F.6
  • 15
    • 47749134925 scopus 로고    scopus 로고
    • Association between PPARGC1A polymorphisms and the occurrence of nonalcoholic fatty liver disease (NAFLD)
    • PMID: 18588668
    • Yoneda M, Hotta K, Nozaki Y, Endo H, Uchiyama T, Mawatari H, et al. Association between PPARGC1A polymorphisms and the occurrence of nonalcoholic fatty liver disease (NAFLD) BMC Gastroenterol. 2008; 8:27 doi: 10.1186/1471-230X-8-27 PMID: 18588668
    • (2008) BMC Gastroenterol. , vol.8 , pp. 27
    • Yoneda, M.1    Hotta, K.2    Nozaki, Y.3    Endo, H.4    Uchiyama, T.5    Mawatari, H.6
  • 16
    • 49849093922 scopus 로고    scopus 로고
    • Val227Ala substitution in the peroxisome proliferator activated receptor alpha (PPAR alpha) gene associated with non-alcoholic fatty liver disease and decreased waist circumference and waist-to-hip ratio
    • PMID: 18853997
    • Chen S, Li Y, Li S, Yu C. A Val227Ala substitution in the peroxisome proliferator activated receptor alpha (PPAR alpha) gene associated with non-alcoholic fatty liver disease and decreased waist circumference and waist-to-hip ratio. J Gastroenterol Hepatol. 2008; 23: 1415-1418 doi: 10.1111/j.1440-1746.2008.05523.x PMID: 18853997
    • (2008) J Gastroenterol Hepatol. , vol.23 , pp. 1415-1418
    • Chen, S.1    Li, Y.2    Li, S.3    Yu, C.A.4
  • 17
    • 39549113664 scopus 로고    scopus 로고
    • Effect of peroxisome proliferator-activated receptors-gamma and co-activator-1alpha genetic polymorphisms on plasma adiponectin levels and susceptibility of non-alcoholic fatty liver disease in Chinese people
    • PMID: 17999673
    • Hui Y, Yu-Yuan L, Yu-Qiang N, Wei-Hong S, Yan-Lei D, Xiao-Bo L, et al. Effect of peroxisome proliferator-activated receptors-gamma and co-activator-1alpha genetic polymorphisms on plasma adiponectin levels and susceptibility of non-alcoholic fatty liver disease in Chinese people. Liver Int. 2008; 28:385-392. PMID: 17999673
    • (2008) Liver Int. , vol.28 , pp. 385-392
    • Hui, Y.1    Yu-Yuan, L.2    Yu-Qiang, N.3    Wei-Hong, S.4    Yan-Lei, D.5    Xiao-Bo, L.6
  • 18
    • 84896939136 scopus 로고    scopus 로고
    • Genetic variants in GCKR and PNPLA3 confer susceptibility to nonalcoholic fatty liver disease in obese individuals
    • PMID: 24477042
    • Lin YC, Chang PF, Chang MH, Ni YH.Genetic variants in GCKR and PNPLA3 confer susceptibility to nonalcoholic fatty liver disease in obese individuals. Am J Clin Nutr. 2014; 99: 869-874 doi: 10.3945/ajcn.113.079749 PMID: 24477042
    • (2014) Am J Clin Nutr. , vol.99 , pp. 869-874
    • Lin, Y.C.1    Chang, P.F.2    Chang, M.H.3    Ni, Y.H.4
  • 19
    • 84893760888 scopus 로고    scopus 로고
    • PNPLA3 gene polymorphism accounts for fatty liver in community subjects without metabolic syndrome
    • PMID: 24417250
    • Shen J, Wong GL, Chan HL, Chan HY, Yeung DK, Chan RS, et al. PNPLA3 gene polymorphism accounts for fatty liver in community subjects without metabolic syndrome. Aliment Pharmacol Ther. 2014; 39: 532-539. doi: 10.1111/apt.12609 PMID: 24417250
    • (2014) Aliment Pharmacol Ther. , vol.39 , pp. 532-539
    • Shen, J.1    Wong, G.L.2    Chan, H.L.3    Chan, H.Y.4    Yeung, D.K.5    Chan, R.S.6
  • 20
    • 0038644536 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: Summary of an AASLD Single Topic Conference
    • Neuschwander-Tetri BA, Caldwell SH. Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference. Hepatology. 2003; 37: 1202-1219.
    • (2003) Hepatology. , vol.37 , pp. 1202-1219
    • Neuschwander-Tetri, B.A.1    Caldwell, S.H.2
  • 21
    • 51349134000 scopus 로고    scopus 로고
    • Genetic variants associated with insulin resistance and metabolic syndrome in young Asian Indians with myocardial infarction
    • PMID: 18710329
    • Ranjith N, Pegoraro RJ, Naidoo DP, Shanmugam R, Rom L. Genetic variants associated with insulin resistance and metabolic syndrome in young Asian Indians with myocardial infarction. Metab. Syndr. Relat. Disord. 2008; 6: 209-214. doi: 10.1089/met.2008.0023 PMID: 18710329
    • (2008) Metab. Syndr. Relat. Disord. , vol.6 , pp. 209-214
    • Ranjith, N.1    Pegoraro, R.J.2    Naidoo, D.P.3    Shanmugam, R.4    Rom, L.5
  • 22
    • 84899653695 scopus 로고    scopus 로고
    • Controlled attenuation parameter for noninvasive assessment of hepatic steatosis in Chinese patients
    • PMID: 24782622
    • Shen F, Zheng RD, Mi YQ, Wang XY, Pan Q, Chen GY, et al. Controlled attenuation parameter for noninvasive assessment of hepatic steatosis in Chinese patients. World J Gastroenterol. 2014; 20: 4702-4711. doi: 10.3748/wjg.v20.i16.4702 PMID: 24782622
    • (2014) World J Gastroenterol. , vol.20 , pp. 4702-4711
    • Shen, F.1    Zheng, R.D.2    Mi, Y.Q.3    Wang, X.Y.4    Pan, Q.5    Chen, G.Y.6
  • 23
    • 63049122519 scopus 로고    scopus 로고
    • Correlation between adiponectin polymorphisms and non-alcoholic fatty liver disease with or without metabolic syndrome in Chinese population
    • PMID: 19246975
    • Wang ZL, Xia B, Shrestha U, Jiang L, Ma CW, Chen Q, et al. Correlation between adiponectin polymorphisms and non-alcoholic fatty liver disease with or without metabolic syndrome in Chinese population. Endocrinol Invest. 2008; 31: 1086-1091. PMID: 19246975
    • (2008) Endocrinol Invest. , vol.31 , pp. 1086-1091
    • Wang, Z.L.1    Xia, B.2    Shrestha, U.3    Jiang, L.4    Ma, C.W.5    Chen, Q.6
  • 24
    • 70349652353 scopus 로고    scopus 로고
    • Influence of adiponectin gene polymorphisms in Japanese patients with non-alcoholic fatty liver disease
    • Tokushige K, Hashimoto E, Noto H, Yatsuji S, Taniai M, Torii N, et al. Influence of adiponectin gene polymorphisms in Japanese patients with non-alcoholic fatty liver disease. J Gastroenterol. 2009; 44: 976-982.
    • (2009) J Gastroenterol. , vol.44 , pp. 976-982
    • Tokushige, K.1    Hashimoto, E.2    Noto, H.3    Yatsuji, S.4    Taniai, M.5    Torii, N.6
  • 25
    • 77950158252 scopus 로고    scopus 로고
    • Influence of polygenetic polymorphisms on the susceptibility to non-alcoholic fatty liver disease of Chinese people
    • Zhou YJ, Li YY, Nie YQ, Yang H, Zhan Q, Huang J, et al. Influence of polygenetic polymorphisms on the susceptibility to non-alcoholic fatty liver disease of Chinese people. J Gastroenterol Hepatol. 2010; 25: 772-777.
    • (2010) J Gastroenterol Hepatol. , vol.25 , pp. 772-777
    • Zhou, Y.J.1    Li, Y.Y.2    Nie, Y.Q.3    Yang, H.4    Zhan, Q.5    Huang, J.6
  • 26
    • 84863394339 scopus 로고    scopus 로고
    • Association of adiponectin gene functional polymorphisms (-11377C/G and +45T/G) with nonalcoholic fatty liver disease
    • PMID: 22269154
    • Gupta AC, Misra R, Sakhuja P, Singh Y, Basir SF, Sarin SK. Association of adiponectin gene functional polymorphisms (-11377C/G and +45T/G) with nonalcoholic fatty liver disease. Gene. 2012; 496: 63-67. doi: 10.1016/j.gene.2011.12.023 PMID: 22269154
    • (2012) Gene. , vol.496 , pp. 63-67
    • Gupta, A.C.1    Misra, R.2    Sakhuja, P.3    Singh, Y.4    Basir, S.F.5    Sarin, S.K.6
  • 27
    • 42249084876 scopus 로고    scopus 로고
    • Adiponectin gene polymorphisms modulate acute adiponectin response to dietary fat: Possible pathogenetic role in NASH
    • Musso G, Gambino R, De Michieli F, Durazzo M, Pagano G, Cassader M. Adiponectin gene polymorphisms modulate acute adiponectin response to dietary fat: Possible pathogenetic role in NASH. Hepatology. 2008; 47: 1167-1177.
    • (2008) Hepatology. , vol.47 , pp. 1167-1177
    • Musso, G.1    Gambino, R.2    De Michieli, F.3    Durazzo, M.4    Pagano, G.5    Cassader, M.6
  • 28
    • 26244448109 scopus 로고    scopus 로고
    • Lack of association between certain candidate gene polymorphisms and the metabolic syndrome
    • PMID: 15978856
    • Meirhaeghe A, Cottel D, Amouyel P. Lack of association between certain candidate gene polymorphisms and the metabolic syndrome. Mol. Genet. Metab. 2005; 86: 293-299. PMID: 15978856
    • (2005) Mol. Genet. Metab. , vol.86 , pp. 293-299
    • Meirhaeghe, A.1    Cottel, D.2    Amouyel, P.3
  • 29
    • 84881175641 scopus 로고    scopus 로고
    • Association of Adiponectin rs1501299 and rs266729 Gene Polymorphisms With Nonalcoholic Fatty Liver Disease
    • PMID: 23922565
    • Hashemi M, Hanafi Bojd H, Eskandari Nasab E, Bahari A, Hashemzehi NA, Shafieipour S, et al. Association of Adiponectin rs1501299 and rs266729 Gene Polymorphisms With Nonalcoholic Fatty Liver Disease. Hepat Mon. 2013; 13: e9527 doi: 10.5812/hepatmon.9527 PMID: 23922565
    • (2013) Hepat Mon. , vol.13 , pp. e9527
    • Hashemi, M.1    Hanafi Bojd, H.2    Eskandari Nasab, E.3    Bahari, A.4    Hashemzehi, N.A.5    Shafieipour, S.6
  • 30
    • 75049083520 scopus 로고    scopus 로고
    • Adiponectin gene SNP 276G → T, nutrient intakes, and cardiovascular disease risk in Korean type 2 DM patients
    • PMID: 20368963
    • Yu SY, Ryu HK, Park HJ, Choi YJ, Huh KB, Kim WY. Adiponectin gene SNP 276G → T, nutrient intakes, and cardiovascular disease risk in Korean type 2 DM patients. Nutr Res Pract. 2007; 1: 363-370. doi: 10.4162/nrp.2007.1.4.363 PMID: 20368963
    • (2007) Nutr Res Pract. , vol.1 , pp. 363-370
    • Yu, S.Y.1    Ryu, H.K.2    Park, H.J.3    Choi, Y.J.4    Huh, K.B.5    Kim, W.Y.6
  • 31
    • 84907983077 scopus 로고    scopus 로고
    • Association of ADIPOQ polymorphisms with obesity risk: A meta-analysis
    • PMID: 25223469
    • Lu JF, Zhou Y, Huang GH, Jiang HX, Hu BL, Qin SY. Association of ADIPOQ polymorphisms with obesity risk: A meta-analysis. Hum Immunol. 2014; 75: 1062-1068. doi: 10.1016/j.humimm.2014.09.004 PMID: 25223469
    • (2014) Hum Immunol. , vol.75 , pp. 1062-1068
    • Lu, J.F.1    Zhou, Y.2    Huang, G.H.3    Jiang, H.X.4    Hu, B.L.5    Qin, S.Y.6
  • 32
    • 84894282893 scopus 로고    scopus 로고
    • Association of adiponectin gene -11377C>G polymorphism with adiponectin levels and the metabolic syndrome in Thais
    • PMID: 24561985
    • Suriyaprom K, Phonrat B, Tungtrongchitr R. Association of adiponectin gene -11377C>G polymorphism with adiponectin levels and the metabolic syndrome in Thais. Asia Pac J Clin Nutr. 2014; 23: 167-173. doi: 10.6133/apjcn.2014.23.1.01 PMID: 24561985
    • (2014) Asia Pac J Clin Nutr. , vol.23 , pp. 167-173
    • Suriyaprom, K.1    Phonrat, B.2    Tungtrongchitr, R.3
  • 34
    • 84884210651 scopus 로고    scopus 로고
    • Obesity as the common soil of non-alcoholic fatty liver disease and diabetes: Role of adipokines
    • Hui E, Xu A, Bo Yang H, Lam KS. Obesity as the common soil of non-alcoholic fatty liver disease and diabetes: Role of adipokines. J Diabetes Investig. 2013; 4: 413-425,
    • (2013) J Diabetes Investig. , vol.4 , pp. 413-425
    • Hui, E.1    Xu, A.2    Bo Yang, H.3    Lam, K.S.4
  • 35
    • 21244445862 scopus 로고    scopus 로고
    • Plasma adiponectin in nonalcoholic fatty liver is related to hepatic insulin resistance and hepatic fat content, not to liver disease severity
    • PMID: 15797948
    • Bugianesi E, Pagotto U, Manini R, Vanni E, Gastaldelli A, de Iasio R et al. Plasma adiponectin in nonalcoholic fatty liver is related to hepatic insulin resistance and hepatic fat content, not to liver disease severity. J Clin Endocrinol Metab 2005; 90: 3498-3504. PMID: 15797948
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 3498-3504
    • Bugianesi, E.1    Pagotto, U.2    Manini, R.3    Vanni, E.4    Gastaldelli, A.5    De Iasio, R.6
  • 36
    • 30944469306 scopus 로고    scopus 로고
    • Adipokines in NASH: Postprandial lipid metabolism as a link between adiponectin and liver disease
    • PMID: 16231364
    • Musso G, Gambino R, Durazzo M, Biroli G, Carello M, Fagà E, et al. Adipokines in NASH: postprandial lipid metabolism as a link between adiponectin and liver disease. Hepatology 2005; 42: 1175-1183. PMID: 16231364
    • (2005) Hepatology , vol.42 , pp. 1175-1183
    • Musso, G.1    Gambino, R.2    Durazzo, M.3    Biroli, G.4    Carello, M.5    Fagà, E.6
  • 37
    • 84917677294 scopus 로고    scopus 로고
    • FibroScan (Vibration-Controlled Transient Elastography): Where Does It Stand in the United States Practice
    • PMID: 24909907
    • Tapper EB, Castera L, Afdhal NH. FibroScan (Vibration-Controlled Transient Elastography): Where Does It Stand in the United States Practice. Clin Gastroenterol Hepatol 2015; 13: 27-36. doi: 10.1016/j.cgh.2014.04.039 PMID: 24909907
    • (2015) Clin Gastroenterol Hepatol , vol.13 , pp. 27-36
    • Tapper, E.B.1    Castera, L.2    Afdhal, N.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.