Semi-automated nanoprecipitation-system - An option for operator independent, scalable and size adjustable nanoparticle synthesis

Pharmaceutical Research

Volumn 32, Issue 6, 2015, Pages 1859-1863

  Rietscher, René ^a   Thum, Carolin ^b   Lehr, Claus Michael ^a,c   Schneider, Marc ^b  

^a SAARLAND UNIVERSITY   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c SAARLAND UNIVERSITY   (Germany)

Author keywords

continuous nanoparticle preparation; nanoprecipitation; PLGA; SAN System; scale up

Indexed keywords

DRUG CARRIER; NANOPARTICLE; POLYGLACTIN;

AUTOMATION; CHEMISTRY; DEVICES; EQUIPMENT DESIGN; MEDICINAL CHEMISTRY; NANOTECHNOLOGY; PHARMACEUTICS; PRECIPITATION; PROCEDURES; SYRINGE; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; FLOW RATE; INJECTION; PARTICLE SIZE; PRIORITY JOURNAL; PUMP; SCANNING ELECTRON MICROSCOPY; SEMI AUTOMATED NANOPRECIPITATION SYSTEM;

AUTOMATION; CHEMICAL PRECIPITATION; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; EQUIPMENT DESIGN; NANOPARTICLES; NANOTECHNOLOGY; POLYGLACTIN 910; SYRINGES; TECHNOLOGY, PHARMACEUTICAL;

EID: 84934965200     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-014-1612-z     Document Type: Article

References (18)

1. Allen TM, Cullis PR. Drug delivery systems: entering the mainstream. Science. 2004;303:1818-22.
2. Kammona O, Kiparissides C. Recent advances in nanocarrier-based mucosal delivery of biomolecules. J Control Release. 2012;161:781-94.
3. Goeran L, Hubert R, Gert R, Birgit S-K, Peter G, Jean-Philippe P, et al. Considerations on a definition of nanomaterial for regulatory purposes. Publications Office of the European Union; 2010.
4. Davis ME, Chen ZG, Shin DM. Nanoparticle therapeutics: an emerging treatment modality for cancer. Nat Rev Drug Discov. Nature Publishing Group. 2008;7:771-82.
5. Soppimath KS, Aminabhavi TM, Kulkarni AR, Rudzinski WE. Biodegradable polymeric nanoparticles as drug delivery devices. J Control Release. 2001;70:1-20.
6. Des Rieux A, Fievez V, Garinot M, Schneider Y-J, Préat V. Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach. J Control Release. 2006;116:1-27.
7. Swaminathan J, Ehrhardt C. Liposomal delivery of proteins and peptides. London: Informa UK Ltd; 2012.
8. Fessi H, Puisieux F, Devissaguet JP, Ammoury N, Benita S. Nanocapsule formation by interfacial polymer deposition following solvent displacement. Int J Pharm. 1989;55:R1-4.
9. Beck-Broichsitter M, Rytting E, Lebhardt T, Wang X, Kissel T. Preparation of nanoparticles by solvent displacement for drug delivery: a shift in the "ouzo region" upon drug loading. Eur J Pharm Sci. 2010;41:244-53.
10. François G, Katz JL. Nanoparticles and nanocapsules created using the Ouzo effect: spontaneous emulisification as an alternative to ultrasonic and high-shear devices. ChemPhysChem. 2005;6:209-16.
11. Quintanar-Guerrero D, Allémann E, Doelker E, Fessi H. Preparation and characterization of nanocapsules from preformed polymers by a new process based on emulsification-diffusion technique. Pharm Res. Kluwer Academic Publishers-Plenum Publishers. 1998;15:1056-62.
12. Mora-Huertas CE, Fessi H, Elaissari A. Polymer-based nanocapsules for drug delivery. Int J Pharm. Elsevier Science BV, PO Box 211, 1000 AE Amsterdam, Netherlands. 2010;385:113-42.
13. Xie H, Smith JW. Fabrication of PLGA nanoparticles with a fluidic nanoprecipitation system. J Nanobiotechnol. 2010;8:18.
14. Guan X, Martonen TB. Simulations of flow in curved tubes. Aerosol Sci Technol. Taylor & Francis. 1997;26:485-504.
15. Avila K, Moxey D, de Lozar A, Avila M, Barkley D, Hof B. The onset of turbulence in pipe flow. Science. 2011;333:192-6.
16. Keck CM, Müller RH. Photonenkorrelationsspektroskopie. Mod Pharm Technol. 2009;56-60.
17. Plasari E, Grisoni PH, Villermaux J. Influence of process parameters on the precipitation of organic nanoparticles by drowning-out. Chem Eng Res Des. 1997;75:237-44.
18. Chorny M, Fishbein I, Danenberg HD, Golomb G. Lipophilic drug loaded nanospheres prepared by nanoprecipitation: effect of formulation variables on size, drug recovery and release kinetics. J Control Release. 2002;83:389-400.