Structure-based discovery of an immunomodulatory inhibitor of TLR1-TLR2 heterodimerization from a natural product-like database

Chemical Communications

Volumn 51, Issue 56, 2015, Pages 11178-11181

  Zhong, Zhangfeng ^a   Liu, Li Juan ^a   Dong, Zhi Qiang ^a   Lu, Lihua ^b   Wang, Modi ^b   Leung, Chung Hang ^a   Ma, Dik Lung ^b   Wang, Yitao ^a  

^a University of Macau   (Macao)

^b HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; NATURAL PRODUCT; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR ALPHA; BIOLOGICAL PRODUCT; IMMUNOLOGIC FACTOR;

ANIMAL CELL; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DATA BASE; HYDROGEN BOND; MACROPHAGE; MOLECULAR DOCKING; NONHUMAN; PHAGOCYTOSIS; ANTAGONISTS AND INHIBITORS; CHEMICAL DATABASE; CHEMISTRY; DIMERIZATION; DRUG EFFECTS; HUMAN;

BIOLOGICAL PRODUCTS; DATABASES, CHEMICAL; DIMERIZATION; HUMANS; IMMUNOLOGIC FACTORS; MACROPHAGES; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; TOLL-LIKE RECEPTOR 1; TOLL-LIKE RECEPTOR 2;

EID: 84934784432     PISSN: 13597345     EISSN: 1364548X     Source Type: Journal    
DOI: 10.1039/c5cc02728d     Document Type: Article

References (25)

1. E. K. Jo C. S. Yang C. H. Choi C. V. Harding Cell. Microbiol. 2007 9 1087
2. K. Takeda S. Akira Int. Immunol. 2005 17 1
3. T. H. Mogensen Clin. Microbiol. Rev. 2009 22 240
4. E. J. Hennessy A. E. Parker L. A. J. ONeill Nat. Rev. Drug Discovery 2010 9 293
5. D. K. Zhang G. L. Zhang M. S. Hayden M. B. Greenblatt C. Bussey R. A. Flavell S. Ghosh Science 2004 303 1522
6. K. Takeda S. Akira Semin. Immunol. 2004 16 3
7. O. Takeuchi S. Akira Cell 2010 140 805
8. M. Lamkanfi L. Vande Walle T. D. Kanneganti Immunol. Rev. 2011 243 163
9. E. A. Kurt-Jones M. Chan S. H. Zhou J. Wang G. Reed R. Bronson M. M. Arnold D. M. Knipe R. W. Finberg Proc. Natl. Acad. Sci. U. S. A. 2004 101 1315
10. S. H. Zhou A. M. Cerny G. Bowen M. Chan D. M. Knipe E. A. Kurt-Jones R. W. Finberg Antiviral Res. 2010 87 295
11. K. W. Boehme M. Guerrero T. Compton J. Immunol. 2006 177 7094
12. C. D. Cuevas S. R. Ross J. Virol. 2014 88 7703
13. K. Cheng X. Wang S. Zhang H. Yin Angew. Chem., Int. Ed. 2012 51 12246
14. M. S. Butler A. A. B. Robertson M. A. Cooer Nat. Prod. Rep. 2014 31 1612
15. L.-J. Liu K.-H. Leung D. S.-H. Chan Y. T. Wang D.-L. Ma C.-H. Leung Cell Death Dis. 2014 5 e1293
16. D.-L. Ma D. S.-H. Chan G. Wei H.-J. Zhong H. Yang L. T. Leung E. A. Gullen P. Chiu Y. C. Cheng C.-H. Leung Chem. Commun. 2014 50 13885
17. H.-J. Zhong L.-J. Liu C. M. Chong L. Lu M. Wang D. S.-H. Chan P. W. H. Chan S. M. Y. Lee D.-L. Ma C.-H. Leung Plos One 2014 9 e92905
18. D.-L. Ma D. S.-H. Chan C.-H. Leung Chem. Sci. 2011 2 1656
19. C.-H. Leung D. S.-H. Chan H. Yang R. Abagyan S. M. Y. Lee G. Y. Zhu W. F. Fong D.-L. Ma Chem. Commun. 2011 47 2511
20. P. Muller M. Muller-Anstett J. Wagener Q. Gao S. Kaesler M. Schaller T. Biedermann F. Gotz Infect. Immun. 2010 78 4243
21. K. Kurokawa H. Lee K. B. Roh M. Asanuma Y. S. Kim H. Nakayama A. Shiratsuchi Y. Choi O. Takeuchi H. J. Kang et al. J. Biol. Chem. 2009 284 8406
22. T. Shimizu Y. Kida K. Kuwano Immunology 2007 121 473
23. A. Oeckinghaus S. Ghosh Cold Spring Harbor Perspect. Biol. 2009 1 1
24. S. Redlich S. Ribes S. Schutze H. Eiffert R. Nau J. Neuroinflammation 2013 10 71
25. S. Ribes S. Ebert D. Czesnik T. Regen A. Zeug S. Bukowski A. Mildner H. Eiffert U. K. Hanisch S. Hammerschmidt Infect. Immun. 2009 77 557