Mitochondrial ROS production initiates Aβ1-40-mediated up-regulation of L-type Ca2+ channels during chronic hypoxia

Advances in Experimental Medicine and Biology

Volumn 580, Issue , 2006, Pages 197-201

  Fearon, Ian M ^a   Brown, Stephen T ^b   Hudasek, Kristin ^b   Scragg, Jason L ^c   Boyle, John P ^c   Peers, Chris ^c  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b MCMASTER UNIVERSITY   (Canada)

^c UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84934442855     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/0-387-31311-7_30     Document Type: Conference Paper

References (9)

1. Abramov, A.Y., Canevari, L. and Duchen, M.R. (2004). Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase. J. Neurosci. 24, 565-575.
2. Hensley, K., Carney, J.M., Mattson, M.P., Aksenova, M., Harris, M., Wu, J.F., Floyd, R.A. and Butterfield, D.A. (1994). A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease. Proc. Natl. Acad. Sci. U.S.A. 91, 3270-3274.
3. 1C subunits but does not mediate their sensitivity to acute hypoxia. Biochem. Biophys. Res. Commun. 318, 135-141.
4. King, M.P. and Attardi, G. (1989). Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation. Science 246, 500-503.
5. Mattson, M.P. (1997). Cellular actions of β-amyloid precursor protein and its soluble and fibrillogenic derivatives, Physiol. Rev. 77, 1081-1132.
6. Moroney, J.T., Bagiella, E., Desmond, D.W., Paik, M.C., Stern, Y. and Tatemichi, T.K. (1996). Risk factors for incident dementia after stroke. Role of hypoxic and ischemic disorders. Stroke 27, 1283-1289.
7. Schofield, C.J. and Ratcliffe, P.J. (2004). Oxygen sensing by HIF hydroxylases. Nat. Rev. Mol. Cell Biol. 5, 343-354.
8. 2+ channels. FASEB J. 19, 150-152.
9. Smith, M.A., Drew, K.L., Nunomura, A., Takeda, A., Hirai, K., Zhu, X., Atwood, C.S., Raina, A.K., Rottkamp, C.A., Sayre, L.M., Friedland, R.P. and Perry, G. (2002). Amyloid-β, tau alterations and mitochondrial dysfunction in Alzheimer disease: the chickens or the eggs? Neurochem. Int. 40, 527-531.