The nsp2 proteins of mouse hepatitis virus and SARS coronavirus are dispensable for viral replication

Advances in Experimental Medicine and Biology

Volumn 581, Issue , 2006, Pages 67-72

  Graham, Rachel L ^a   Sims, Amy C ^a   Baric, Ralph S ^a   Denison, Mark R ^a  

^a VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84934440782     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-0-387-33012-9_10     Document Type: Conference Paper

References (11)

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2. Yount, B., Curtis, K. M., Fritz, E. A., Hensley, L. E., Jahrling, P. B., Prentice, E., Denison, M. R., Geisbert, T. W., and Baric, R. S., 2003, Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus, Proc. Natl. Acad. Sci. USA 100, 12995-13000.
3. Prentice, E., McAuliffe, J., Lu, X., Subbarao, K., and Denison, M. R., 2004, Identification and characterization of severe acute respiratory syndrome coronavirus replicase proteins, J. Virol. 78, 9977-9986.
4. Bost, A. G., Carnahan, R. H., Lu, X. T., and Denison, M. R., 2000, Four proteins processed from the replicase gene polyprotein of mouse hepatitis virus colocalize in the cell periphery and adjacent to sites of virion assembly, J. Virol. 74, 3379-3387.
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6. Denison, M. R., Hughes, S. A., and Weiss, S. R., 1995, Identification and characterization of a 65-kDa protein processed from the gene 1 polyprotein of the murine coronavirus MHV-A59, Virology 207, 316-320.
7. Schiller, J. J., Kanjanahaluethai, A., and Baker, S. C., 1998, Processing of the coronavirus mhv-jhm polymerase polyprotein: identification of precursors and proteolytic products spanning 400 kilodaltons of ORF1a, Virology 242, 288-302.
8. de Vries, A. A. F., Horzinek, M. C., Rottier, P. J. M., and deGroot, R. J., 1997, The genome organization of the nidovirales: similarities and differenced between arteri-, toro, and coronaviruses, Sem. Virology 8, 33-47.
9. Ziebuhr, J., Snijder, E. J., and Gorbalenya, A. E., 2000, Virus-encoded proteinases and proteolytic processing in the Nidovirales, J. Gen. Virol. 81, 853-879.
10. Ziebuhr, J., Thiel, V., and Gorbalenya, A. E., 2001, The autocatalytic release of a putative RNA virus transcription factor from its polyprotein precursor involves two paralogous papain-like proteases that cleave the same peptide bond, J. Biol. Chem. 276, 33220-33232.
11. Sperry, S. M., Kazi, L., Graham, R. L., Baric, R. S., Weiss, S. R., and Denison, M. R., 2005, Single-amino-acid substitutions in open reading frame (ORF) 1b-nsp14 and ORF 2a proteins of the coronavirus mouse hepatitis virus are attenuating in mice, J. Virol. 79, 3391-4000.