Coagulation profile changes and safety of epidural analgesia after hepatectomy: a retrospective study

Journal of Anesthesia

Volumn 29, Issue 3, 2015, Pages 367-372

  Elterman, Kelly G ^a   Xiong, Zhiling ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Coagulopathy; Epidural anesthesia; Hepatectomy

Indexed keywords

ADULT; ADVERSE EFFECTS; AGED; BLOOD CLOTTING; BLOOD COAGULATION DISORDERS; CATHETERIZATION; EPIDURAL ANESTHESIA; EPIDURAL SPACE; FEMALE; HUMAN; INTERNATIONAL NORMALIZED RATIO; LIVER; LIVER FUNCTION TEST; LIVER RESECTION; MALE; MIDDLE AGED; PARTIAL THROMBOPLASTIN TIME; PHYSIOLOGY; PROCEDURES; PROTHROMBIN TIME; RETROSPECTIVE STUDY; SURGERY; THROMBOCYTE COUNT; VERY ELDERLY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; ANALGESIA, EPIDURAL; BLOOD COAGULATION; BLOOD COAGULATION DISORDERS; CATHETERIZATION; EPIDURAL SPACE; FEMALE; HEPATECTOMY; HUMANS; INTERNATIONAL NORMALIZED RATIO; LIVER; LIVER FUNCTION TESTS; MALE; MIDDLE AGED; PARTIAL THROMBOPLASTIN TIME; PLATELET COUNT; PROTHROMBIN TIME; RETROSPECTIVE STUDIES; YOUNG ADULT;

EID: 84934440335     PISSN: 09138668     EISSN: 14388359     Source Type: Journal    
DOI: 10.1007/s00540-014-1933-4     Document Type: Article

References (21)

1. Wrighton LJ, O’Bosky KR, Namm JP, Senthil M. Postoperative management after hepatic resection. J Gastrointest Oncol. 2012;3:41–7.
2. Jarnagin WR, Gonen M, Fong Y, DeMatteo RP, Ben-Porat L, Little S, Corvera C, Weber S, Blumgart LH. Improvement in perioperative outcome after hepatic resection: analysis of 1,803 consecutive cases over the past decade. Ann Surg. 2002;236:397–406.
3. Ryan WH, Hummel BW, McClelland RN. Reduction in the morbidity and mortality of major hepatic resection. Experience with 52 patients. Am J Surg. 1982;144:740–3.
4. Ballantyne JC, Carr DB, de Ferranti S, Suarez T, Lau J, Chalmers TC, Angelillo IF, Mosteller F. The comparative effects of postoperative analgesic therapies on pulmonary outcome: cumulative meta-analyses of randomized, controlled trials. Anesth Analg. 1998;86:598–612.
5. Matot I, Scheinin O, Eid A, Jurim O. Epidural anesthesia and analgesia in liver resection. Anesth Analg. 2002;95:1179–81.
6. Shontz R, Karuparthy V, Temple R, Brennan TJ. Prevalence and risk factors predisposing to coagulopathy in patients receiving epidural analgesia for hepatic surgery. Reg Anesth Pain Med. 2009;34:308–11.
7. Weinberg L, Scurrah N, Gunning K, McNicol L. Postoperative changes in prothrombin time following hepatic resection: implications for perioperative analgesia. Anaesth Intensiv Care. 2006;34:438–43.
8. Choi SJ, Gwak MS, Ko JS, Lee H, Yang M, Lee SM, Kim GS, Kim MH. The changes in coagulation profile and epidural catheter safety for living liver donors: a report on 6 years of our experience. Liver Transplant. 2007;13:62–70.
9. Schulick R. Hepatobiliary anatomy. In: Mulholland M, Lillemoe K, Doherty G, Maier R, Upchurch Jr G, editors. Greenfield’s surgery scientific principles and practice. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2006. p. 892–909.
10. Suc B, Panis Y, Belghiti J, Fekete F. ‘Natural history’ of hepatectomy. Br J Surg. 1992;79:39–42.
11. Yuan FS, Ng SY, Ho KY, Lee SY, Chung AY, Poopalalingam R. Abnormal coagulation profile after hepatic resection: the effect of chronic hepatic disease and implications for epidural analgesia. J Clin Anesth. 2012;24:398–403.
12. Kim YK, Shin WJ, Song JG, Jun IG, Kim HY, Seong SH, Sang BH, Hwang GS. Factors associated with changes in coagulation profiles after living donor hepatectomy. Transplant Proc. 2010;42:2430–5.
13. Siniscalchi A, Begliomini B, De Pietri L, Braglia V, Gazzi M, Masetti M, Di Benedetto F, Pinna AD, Miller CM, Pasetto A. Increased prothrombin time and platelet counts in living donor right hepatectomy: implications for epidural anesthesia. Liver Transplant. 2004;10:1144–9.
14. Stamenkovic DM, Jankovic ZB, Toogood GJ, Lodge JP, Bellamy MC. Epidural analgesia and liver resection: postoperative coagulation disorders and epidural catheter removal. Minerva Anestesiol. 2011;77:671–9.
15. Horlocker TT. Regional anaesthesia in the patient receiving antithrombotic and antiplatelet therapy. Br J Anaesth. 2011;107(Suppl 1):i96–106.
16. Lim HJ, Koay CK, Lee LS. Postoperative coagulopathy after liver resection—implications for epidural analgesia. Anaesth Intensive Care. 2006;34:118–9.
17. Tsui SL, Yong BH, Ng KF, Yuen TS, Li CC, Chui KY. Delayed epidural catheter removal: the impact of postoperative coagulopathy. Anaesth Intensive Care. 2004;32:630–6.
18. Barton JS, Riha GM, Differding JA, Underwood SJ, Curren JL, Sheppard BC, Pommier RF, Orloff SL, Schreiber MA, Billingsley KG. Coagulopathy after a liver resection: is it over diagnosed and over treated? HPB. 2013;15(11):865–71.
19. Fazakas J, Toth S, Fule B, Smudla A, Mándli T, Radnai M, Doros A, Nemes B, Kóbori L. Epidural anesthesia? No, of course. Transplant Proc. 2008;40:1216–7.
20. Tzimas P, Prout J, Papadopoulos G, Mallett SV. Epidural anaesthesia and analgesia for liver resection. Anaesthesia. 2013;68:628–35.
21. Horlocker TT, Wedel DJ, Rowlingson JC, Enneking FK, Kopp SL, Benzon HT, Brown DL, Heit JA, Mulroy MF, Rosenquist RW, Tryba M, Yuan CS. Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (Third Edition). Reg Anesth Pain Med. 2010;35:64–101.