-
1
-
-
0024561482
-
New antitumor monoclonal antibody-vinca conjugates LY203725 and related compounds: Design, preparation and representative in vivo activity
-
Laguzza BC, Nichols CL et al (1989) New antitumor monoclonal antibody-vinca conjugates LY203725 and related compounds: Design, preparation and representative in vivo activity. J Med Chem 32:548-555
-
(1989)
J Med Chem
, vol.32
, pp. 548-555
-
-
Laguzza, B.C.1
Nichols, C.L.2
-
2
-
-
0025185802
-
Evaluation in vitro of Adriamycin immunoconjugates synthesized using an acid-sensitive hydrazine linker
-
Greenfield RS, Kaneko T et al (1990) Evaluation in vitro of Adriamycin immunoconjugates synthesized using an acid-sensitive hydrazine linker. Cancer Res 50:6600-6607
-
(1990)
Cancer Res
, vol.50
, pp. 6600-6607
-
-
Greenfield, R.S.1
Kaneko, T.2
-
3
-
-
0026583728
-
The influence of synthetic conditions on the stability of methotrexate-monoclonal antibody conjugates determined by reversed phase high performance liquid chromatography
-
Hudecz F, Garnett MC et al (1992) The influence of synthetic conditions on the stability of methotrexate-monoclonal antibody conjugates determined by reversed phase high performance liquid chromatography. Biomed Chromatogr 6:128-132
-
(1992)
Biomed Chromatogr
, vol.6
, pp. 128-132
-
-
Hudecz, F.1
Garnett, M.C.2
-
4
-
-
0026593928
-
Immunoconjugates containing novel maytansinoids: Promising anticancer drugs
-
Chari RV, Martell BA et al (1992) Immunoconjugates containing novel maytansinoids: Promising anticancer drugs. Cancer Res 52:127-131
-
(1992)
Cancer Res
, vol.52
, pp. 127-131
-
-
Chari, R.V.1
Martell, B.A.2
-
5
-
-
0027134326
-
6-Maleimidocaproyl hydrazine of doxorubicin -new derivative for the preparation of immunoconjugates of doxorubicin
-
Willner D, Trail PA et al (1993) (6-Maleimidocaproyl) hydrazine of doxorubicin -new derivative for the preparation of immunoconjugates of doxorubicin. Bioconjug Chem 4:521-527
-
(1993)
Bioconjug Chem
, vol.4
, pp. 521-527
-
-
Willner, D.1
Trail, P.A.2
-
6
-
-
0027194197
-
Preparation and characterization of monoclonal antibody conjugates of the calicheamicins; a novel and potent family of antitumor antibiotics
-
Hinman LM, Hamann PR et al (1993) Preparation and characterization of monoclonal antibody conjugates of the calicheamicins; a novel and potent family of antitumor antibiotics. Cancer Res 53:3336-3342
-
(1993)
Cancer Res
, vol.53
, pp. 3336-3342
-
-
Hinman, L.M.1
Hamann, P.R.2
-
7
-
-
0029093035
-
Enhancement of the selectivity and antitumor efficacy of a CC-1065 analogue through immunoconjugate formation
-
Chari RV, Jackel KA et al (1995) Enhancement of the selectivity and antitumor efficacy of a CC-1065 analogue through immunoconjugate formation. Cancer Res 55:44079-44084
-
(1995)
Cancer Res
, vol.55
, pp. 44079-44084
-
-
Chari, R.V.1
Jackel, K.A.2
-
9
-
-
6044223544
-
Effects of drug loading on the antitumor activity of a monoclonal antibody drug conjugate
-
Hamblett KJ, Senter PD et al (2004) Effects of drug loading on the antitumor activity of a monoclonal antibody drug conjugate. Clin Cancer Res 10:7063-7070
-
(2004)
Clin Cancer Res
, vol.10
, pp. 7063-7070
-
-
Hamblett, K.J.1
Senter, P.D.2
-
10
-
-
79952718320
-
Analytical methods for physicochemical characterization of antibody drug conjugates
-
Wakankar A, Chen Y et al (2011) Analytical methods for physicochemical characterization of antibody drug conjugates. MAbs 3 (2):161-172
-
(2011)
MAbs
, vol.3
, Issue.2
, pp. 161-172
-
-
Wakankar, A.1
Chen, Y.2
-
11
-
-
33745684533
-
Engineered antibody-drug conjugates with defined sites and stoichiometries of drug attachment
-
McDonagh CF, Turcott E et al (2006) Engineered antibody-drug conjugates with defined sites and stoichiometries of drug attachment. Protein Eng Des Sel 19:299-307
-
(2006)
Protein Eng Des Sel
, vol.19
, pp. 299-307
-
-
McDonagh, C.F.1
Turcott, E.2
-
12
-
-
24344456964
-
Structural characterization of the maytansinoidmonoclonal antibody immunoconjugate, huN901-DM1, by mass spectrometry
-
Wang L, Amphlett G et al (2005) Structural characterization of the maytansinoidmonoclonal antibody immunoconjugate, huN901-DM1, by mass spectrometry. Protein Sci 14:436-446
-
(2005)
Protein Sci
, vol.14
, pp. 436-446
-
-
Wang, L.1
Amphlett, G.2
-
13
-
-
21244469077
-
Analysis of the composition of immunoconjugates using sizeexclusion chromatography coupled to mass spectrometry
-
Lazar AC, Wang L et al (2005) Analysis of the composition of immunoconjugates using sizeexclusion chromatography coupled to mass spectrometry. Rapid Commun Mass Spectrom 19:1806-1814
-
(2005)
Rapid Commun Mass Spectrom
, vol.19
, pp. 1806-1814
-
-
Lazar, A.C.1
Wang, L.2
-
14
-
-
77957590621
-
Engineered thiotrastuzumab-DM1 conjugate with an improved therapeutic index to target human epidermal growth factor receptor 2-positive breast cancer
-
Junutula JR, Flagella KM et al (2010) Engineered thiotrastuzumab-DM1 conjugate with an improved therapeutic index to target human epidermal growth factor receptor 2-positive breast cancer. Clin Cancer Res 16:4769-4778
-
(2010)
Clin Cancer Res
, vol.16
, pp. 4769-4778
-
-
Junutula, J.R.1
Flagella, K.M.2
-
15
-
-
79952450423
-
Characterization of intact antibody-drug conjugates from plasma/ serum in vivo by affinity capture capillary liquid chromatography-mass spectrometry
-
Xu K, Liu L et al (2011) Characterization of intact antibody-drug conjugates from plasma/ serum in vivo by affinity capture capillary liquid chromatography-mass spectrometry. Anal Biochem 412:56-66
-
(2011)
Anal Biochem
, vol.412
, pp. 56-66
-
-
Xu, K.1
Liu, L.2
-
16
-
-
0026333035
-
Matrixassisted UV-laser desorption/ionization mass spectrometric analysis of monoclonal antibodies for the determination of carbohydrate, conjugated chelator and conjugated drug content
-
Siegel MM, Hollander IJ et al (1991) Matrixassisted UV-laser desorption/ionization mass spectrometric analysis of monoclonal antibodies for the determination of carbohydrate, conjugated chelator and conjugated drug content. Anal Chem 63:2470-2481
-
(1991)
Anal Chem
, vol.63
, pp. 2470-2481
-
-
Siegel, M.M.1
Hollander, I.J.2
-
17
-
-
77249172711
-
Synthesis and preliminary biological evaluation of high-drugload paclitaxel-Antibody conjugates for tumortargeted chemotherapy
-
Quiles S, Raisch KP et al (2010) Synthesis and preliminary biological evaluation of high-drugload paclitaxel-Antibody conjugates for tumortargeted chemotherapy. J Med Chem 53:586-594
-
(2010)
J Med Chem
, vol.53
, pp. 586-594
-
-
Quiles, S.1
Raisch, K.P.2
-
18
-
-
0037347183
-
Synthesis and biological evaluation of paclitaxel-C225 conjugate as a model for targeted drug delivery
-
Safavy A, Bonner JA et al (2003) Synthesis and biological evaluation of paclitaxel-C225 conjugate as a model for targeted drug delivery. Bionconjug Chem 14:302-310
-
(2003)
Bionconjug Chem
, vol.14
, pp. 302-310
-
-
Safavy, A.1
Bonner, J.A.2
-
19
-
-
84858727362
-
Native intact mass determination of antibodies conjugated with monomethyl Auristatin E and F at interchain cysteine residues
-
Valliere-Douglass JF, McFee WA, Salas-Solano O (2012) Native intact mass determination of antibodies conjugated with monomethyl Auristatin E and F at interchain cysteine residues. Anal Chem 84:2843-2849
-
(2012)
Anal Chem
, vol.84
, pp. 2843-2849
-
-
Valliere-Douglass, J.F.1
McFee, W.A.2
Salas-Solano, O.3
-
20
-
-
79551575923
-
Advances in the assessment and control of the effector functions of therapeutic antibodies
-
Jiang X, Song A et al (2011) Advances in the assessment and control of the effector functions of therapeutic antibodies. Nat Rev Drug Discov 10:101-111
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 101-111
-
-
Jiang, X.1
Song, A.2
-
21
-
-
0029017877
-
Processing of C-terminal lysine and arginine residues of proteins isolated from mammalian cell culture
-
Harris RJ (1995) Processing of C-terminal lysine and arginine residues of proteins isolated from mammalian cell culture. J Chromatogr A 705:129-134
-
(1995)
J Chromatogr A
, vol.705
, pp. 129-134
-
-
Harris, R.J.1
-
22
-
-
25444507922
-
Reductionalkylation strategies for the modification of specific monoclonal antibody disulfides
-
Sun MM, Beam KS et al (2005) Reductionalkylation strategies for the modification of specific monoclonal antibody disulfides. Bioconjug Chem 16:1282-1290
-
(2005)
Bioconjug Chem
, vol.16
, pp. 1282-1290
-
-
Sun, M.M.1
Beam, K.S.2
-
23
-
-
0025908873
-
Selection of buffers and of an ion-pairing agent for thermospray liquid chromatographic-mass spectrometric analysis of ionic compounds
-
Duchateau ALL, Munsters BHM et al (1991) Selection of buffers and of an ion-pairing agent for thermospray liquid chromatographic-mass spectrometric analysis of ionic compounds. J Chromatogr A 552:605-612
-
(1991)
J Chromatogr A
, vol.552
, pp. 605-612
-
-
Duchateau, A.L.L.1
Munsters, B.H.M.2
|