Analysis of s-acylation of proteins

Methods in Molecular Biology

Volumn 446, Issue , 2008, Pages 163-182

  Veit, Michael ^a   Ponimaskin, Evgeni ^b   Schmidt, Michael F G ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

Author keywords

Fatty acids; Hydrophobic modification; Membrane proteins; Protein palmitoylation; S acylation

Indexed keywords

EUKARYOTA; HEXAPODA; VERTEBRATA;

EID: 84934436213     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-60327-84-7_12     Document Type: Article

References (27)

1. Schlesinger, M. J., Veit, M., and Schmidt, M. F. G. (1993) Palmitoylation of cellular and viral proteins, in: Lipid Modifications of Proteins (M. J., Schlesinger., ed.), pp. 2-19, CRC Press, Boca Raton.
2. Resh, M. D. (1999) Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins. Biochem. Biophys. Acta 1451, 1-16.
3. el-Husseini Ael, D. and Bredt, D. S. (2002) Protein palmitoylation: a regulator of neuronal development and function Nat. Rev. Neurosci. 3, 791-802.
4. Bijlmakers, M. J. and Marsh, M. (2003) The on-off story of protein palmitoylation. Trends Cell Biol. 13, 32-42.
5. Smotrys, J. E. and Linder, M. E. (2004) Palmitoylation of intracellular signaling proteins: regulation and function. Annu Rev Biochem 73, 559-587.
6. Veit, M., Reverey, H., and Schmidt, M. F. (1996) Cytoplasmic tail length influences fatty acid selection for acylation of viral glycoproteins. Biochem J 318, 163-172.
7. Veit, M., Sachs, K., Heckelmann, M., Maretzki, D., Hofmann, K. P., and Schmidt, M. F. (1998) Palmitoylation of rhodopsin with S-protein acyltransferase: enzyme catalyzed reaction versus autocatalytic acylation. Biochim Biophys Acta 1394, 90-98.
8. Qanbar, R. and Bouvier, M. (2003) Role of palmitoylation/depalmitoylation reactions in Gprotein-coupled receptor function Pharmacol Ther 97, 1-33.
9. Duncan, J. A. and Gilman, A. G. (1998) A cytoplasmic acyl-protein thioesterase that removes palmitate from G protein alpha subunits and p21 (ras). J. Biol. Chem. 273, 15830-15837.
10. Veit, M. and Schmidt, M. F. (2001) Enzymatic depalmitoylation of viral glycoproteins with acyl-protein thioesterase 1 in vitro. Virology 288, 89-95.
11. Veit, M., Kretzschmar, E., Kuroda, K., Garten, W., Schmidt, M. F., Klenk, H. D., and Rott, R. (1991) Site-specific mutagenesis identifies three cysteine residues in the cytoplasmic tail as acylation sites of influenza virus hemagglutinin. J Virol 65, 2491-2500.
12. Parenti M., Vigano M. A, Newman C. M., Milligan G., and Magee A. I. (1993) A novel N-terminal motif for palmitoylation of G-protein alpha subunits. Biochem J. 291, 349-353.
13. Veit, M., Söllner, T. and Rothman, J. E. (1996) Multiple palmitoylation of Synaptotagmin and the t-SNARE SNAP-25. FEBS-Letters 385, 119-123.
14. Hancock J. F., Magee A. I., Childs J. E., and Marshall C. J. (1989) All ras proteins are polyiso-prenylated but only some are palmitoylated. Cell. 57, 1167-1177.
15. Berger, M., and Schmidt, M. F. (1984) Cell-free fatty acid acylation of Semliki Forest viral polypeptides with microsomal membranes from eukaryotic cells. J Biol Chem 259, 7245-7252.
16. Berthiaume, L. and Resh, M. D. (1995) Biochemical characterization of a palmitoyl acyltransferase activity that palmitoylates myristoylated proteins. J Biol Chem 270, 22399-22405.
17. Dunphy, J. T., Greentree, W. K., Manahan, C. L., and Linder, M. E. (1996) G-protein palmitoyl-transferase activity is enriched in plasma membranes. J Biol Chem 271, 7154-7159.
18. Linder M. E. and Deschenes R. J. (2004) Model organisms lead the way to protein palmitoyltransferases. J Cell Sci. 117, 117521-11526.
19. Duncan, J. A. and Gilman, A. G. (1996) Autoacylation of G protein alpha subunits. J Biol Chem 271, 23594-23600.
20. Bano M. C., Jackson C. S., and Magee A. I. (1998) Pseudo-enzymatic S-acylation of a myristoylated yes protein tyrosine kinase peptide in vitro may reflect non-enzymatic S-acylation in vivo. Biochem J. 330, 723-731.
21. Veit, M. (2000) Palmitoylation of the 25-kDa synaptosomal protein (SNAP-25) in vitro occurs in the absence of an enzyme, but is stimulated by binding to syntaxin. Biochem J. 345, 45-51.
22. Dietrich, L., Gurezka, R., Veit, M., and Ungermann, C. (2004) The SNARE Ykt6 mediates protein palmitoylation during an early stage of homotypic vacuole fusion EMBO-Joumal 23, 45-53.
23. Veit, M. (2004) The human SNARE protein Ykt6 mediates its own palmitoylation at C-terminal cysteine residues. Biochem J. 384, 233-237.
24. Dietrich, L.E. and Ungermann, C. (2004) On the mechanism of protein palmitoylation. EMBO Rep. 5,1053-1057.
25. Qanbar, R. and Bouvier, M. (2004) Determination of protein-bound palmitate turnover rates using a three-compartment model that formally incorporates [3H]palmitate recycling. Biochemistry. 43, 12275-12288.
26. Kim, Y. G., Sohn, E. J., Seo, J., Lee, K. J., Lee, H. S., Hwang, I., Whiteway, M., Sacher, M., and Oh, B. H. (2005) Crystal structure of bet3 reveals a novel mechanism for Golgi localization of tethering factor TRAPP. Nat Struct Mol Biol. 12, 38-45.
27. Bizzozero, O. A., Bixler, H. A., and Pastuszyn, A (2001) Structural determinants influencing the reaction of cysteine-containing peptides with palmitoyl-coenzyme A and other thioesters. Biochim Biophys Acta. 1545, 278-288.