High-sensitivity MALDI-TOF MS quantification of anthrax lethal toxin for diagnostics and evaluation of medical countermeasures

Analytical and Bioanalytical Chemistry

Volumn 407, Issue 10, 2015, Pages 2847-2858

  Boyer, Anne E ^a   Gallegos Candela, Maribel ^a   Quinn, Conrad P ^a   Woolfitt, Adrian R ^a   Brumlow, Judith O ^b   Isbell, Katherine ^a   Hoffmaster, Alex R ^a   Lins, Renato C ^b   Barr, John R ^a  

^a CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^b BATTELLE MEMORIAL INSTITUTE   (United States)

Author keywords

Anthrax; Bacillus anthracis; Diagnostic; Lethal factor; Lethal toxin; MALDI TOF MS; Protective antigen; Quantification

Indexed keywords

ANTIGENS; BACTERIOLOGY; DIAGNOSIS; DISEASES; INDUCTIVELY COUPLED PLASMA; METABOLITES; TOXIC MATERIALS;

ANTHRAX; BACILLUS ANTHRACIS; DIAGNOSTIC; LETHAL FACTOR; LETHAL TOXIN; MALDI TOF MS; PROTECTIVE ANTIGENS; QUANTIFICATION;

LASER DIAGNOSTICS;

BACILLUS ANTHRACIS; MACACA MULATTA;

ANTHRAX TOXIN; ANTIINFECTIVE AGENT; BACTERIAL ANTIGEN; BACTERIAL TOXIN;

AMINO ACID SEQUENCE; ANIMAL; ANTHRAX; ANTIBODY SPECIFICITY; BLOOD; HUMAN; IMMUNOLOGY; IMMUNOPRECIPITATION; MAGNETISM; MATRIX-ASSISTED LASER DESORPTION-IONIZATION MASS SPECTROMETRY; MOLECULAR GENETICS; PROCEDURES; REPRODUCIBILITY; RESPIRATORY TRACT INFECTIONS; RHESUS MONKEY; SENSITIVITY AND SPECIFICITY; TIME FACTOR;

AMINO ACID SEQUENCE; ANIMALS; ANTHRAX; ANTI-BACTERIAL AGENTS; ANTIBODY SPECIFICITY; ANTIGENS, BACTERIAL; BACTERIAL TOXINS; HUMANS; IMMUNOPRECIPITATION; MACACA MULATTA; MAGNETICS; MOLECULAR SEQUENCE DATA; REPRODUCIBILITY OF RESULTS; RESPIRATORY TRACT INFECTIONS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TIME FACTORS;

EID: 84934319076     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-015-8509-5     Document Type: Article

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