Heat Shock Protein A4 Controls Cell Migration and Gastric Ulcer Healing

Digestive Diseases and Sciences

Volumn 60, Issue 4, 2015, Pages 850-857

  Sakurai, Toshiharu ^a   Kashida, Hiroshi ^a   Hagiwara, Satoru ^a   Nishida, Naoshi ^a   Watanabe, Tomohiro ^b   Fujita, Jun ^b   Kudo, Masatoshi ^a  

^a KINKI UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

CXCR4; FSP 1; Gastric cancer; HSP; SDF 1; Twist

Indexed keywords

CXCL12 PROTEIN, HUMAN; CXCL12 PROTEIN, MOUSE; HEAT SHOCK PROTEIN 110; HSPA4 PROTEIN, HUMAN; HSPA4 PROTEIN, MOUSE; STROMAL CELL DERIVED FACTOR 1; TRANSCRIPTION FACTOR TWIST;

ANIMAL; CELL CULTURE; DISEASE MODEL; FIBROBLAST; GASTROSCOPY; HUMAN; METABOLISM; MOUSE; PHYSIOLOGY; STOMACH MUCOSA; STOMACH ULCER; SURGERY; WOUND HEALING;

ANIMALS; CELLS, CULTURED; CHEMOKINE CXCL12; DISEASE MODELS, ANIMAL; FIBROBLASTS; GASTRIC MUCOSA; GASTROSCOPY; HSP110 HEAT-SHOCK PROTEINS; HUMANS; MICE; STOMACH ULCER; TWIST TRANSCRIPTION FACTOR; WOUND HEALING;

EID: 84934286870     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-015-3561-8     Document Type: Article

References (19)

1. Tuxhorn JA, Ayala GE, Smith MJ, et al. Reactive stroma in human prostate cancer: induction of myofibroblast phenotype and extracellular matrix remodeling. Clin Cancer Res. 2002;8:2912–2923.
2. You S, Yoo SA, Choi S, et al. Identification of key regulators for the migration and invasion of rheumatoid synoviocytes through a systems approach. Proc Natl Acad Sci U S A. 2014;111:550–555.
3. Li ZH, Bresnick AR. The S100A4 metastasis factor regulates cellular motility via a direct interaction with myosin-IIA. Cancer Res. 2006;66:5173–5180.
4. Eckes B, Colucci-Guyon E, Smola H, et al. Impaired wound healing in embryonic and adult mice lacking vimentin. J Cell Sci. 2000;113:2455–2462.
5. Wu Y, Zhao RC. The role of chemokines in mesenchymal stem cell homing to myocardium. Stem Cell Rev. 2012;8:243–250.
6. Liu H, Liu S, Li Y, et al. The role of SDF-1-CXCR4/CXCR7 axis in the therapeutic effects of hypoxia-preconditioned mesenchymal stem cells for renal ischemia/reperfusion injury. PLoS One. 2012;7:e34608.
7. Petit I, Jin D, Rafii S. The SDF-1-CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesis. Trends Immunol. 2007;28:299–307.
8. Rabbany SY, Pastore J, Yamamoto M, et al. Continuous delivery of stromal cell-derived factor-1 from alginate scaffolds accelerates wound healing. Cell Transplant. 2010;19:399–408.
9. Zhang M, Mal N, Kiedrowski M, et al. SDF-1 expression by mesenchymal stem cells results in trophic support of cardiac myocytes after myocardial infarction. FASEB J. 2007;21:3197–3207.
10. Gotoh K, Nonoguchi K, Higashitsuji H, et al. Apg-2 has a chaperone-like activity similar to Hsp110 and is overexpressed in hepatocellular carcinomas. FEBS Lett. 2004;560:19–24.
11. Li C, Liu D, Yuan Y, et al. Overexpression of Apg-2 increases cell proliferation and protects from oxidative damage in BaF3-BCR/ABL cells. Int J Oncol. 2010;36:899–904.
12. Adachi T, Sakurai T, Kashida H, et al. Involvement of Heat shock protein A4/Apg-2 in refractory inflammatory bowel disease. Inflamm Bowel Dis. 2015;21:31–39.
13. Okabe S, Amagase K. An overview of acetic acid ulcer models–the history and state of the art of peptic ulcer research. Biol Pharm Bull. 2005;28:1321–1341.
14. Nagata Y, Kudo M, Nagai T, et al. Heat shock protein 27 expression is inversely correlated with atrophic gastritis and intraepithelial neoplasia. Dig Dis Sci. 2013;58:381–388.
15. Mohamed BA, Barakat AZ, Zimmermann WH, et al. Targeted disruption of Hspa4 gene leads to cardiac hypertrophy and fibrosis. J Mol Cell Cardiol. 2012;53:459–468.
16. Alfaro MP, Deskins DL, Wallus M, et al. A physiological role for connective tissue growth factor in early wound healing. Lab Invest. 2013;93:81–95.
17. Tominaga K, Arakawa T, Watanabe T, et al. Increased mRNA levels of transforming growth factor-beta1 and monocyte chemoattractant protein-1 in ulcer relapse caused by interleukin-1beta in rats. Dig Dis Sci. 1998;43:134S–138S.
18. Sakurai T, Kashida H, Watanabe T, et al. Stress response protein cirp links inflammation and tumorigenesis in colitis-associated cancer. Cancer Res. 2014;74:6119–6128.
19. Crawford KC, Vega Flores M, Oehlers SH, et al. Zebrafish heat shock protein a4 genes in the intestinal epithelium are up-regulated during inflammation. Genesis. 2011;49:905–911.