Gender-specific differences in cognitive profiles of patients with Alzheimer's disease: Results of the prospective dementia registry Austria (PRODEM-Austria)

Journal of Alzheimer's Disease

Volumn 46, Issue 3, 2015, Pages 631-637

  Pusswald, Gisela ^a   Lehrner, Johann ^a   Hagmann, Michael ^a   Dal Bianco, Peter ^a   Benke, Thomas ^b   Marisa Loitfelder, ^e   Marksteiner, Josef ^c   Mosbacher, Jochen ^e   Ransmayr, Gerhard ^d   Sanin, Guenter ^b   Schmidt, Reinhold ^e  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^c Regional Hospital Hall in Tirol ^*  (Austria)

^d KEPLER UNIVERSITY HOSPITAL   (Austria)

^e MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

Alzheimer's dementia; Alzheimer's disease; cognitive function; episodic memory; gender differences

Indexed keywords

AGED; ALZHEIMER DISEASE; ANIMAL CATEGORY NAMING TEST; ARTICLE; AUSTRIA; BOSTON NAMING TEST; CLINICAL EXAMINATION; COGNITIVE DEFECT; CONSTRUCTIONAL PRAXIS RECALL TEST; CONSTRUCTIONAL PRAXIS TEST; DEMOGRAPHY; DEPRESSION; DISEASE DURATION; DISEASE REGISTRY; EDUCATIONAL STATUS; EPISODIC MEMORY; FEMALE; GERIATRIC DEPRESSION SCALE; HUMAN; INVESTIGATIVE PROCEDURES; LEARNING; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; NEUROPSYCHOLOGICAL TEST; NEUROPSYCHOLOGY; PHONEMIC VERBAL FLUENCY TEST; PRIORITY JOURNAL; PROSPECTIVE STUDY; SEX DIFFERENCE; TASK PERFORMANCE; TRAIL MAKING TEST; VERBAL MEMORY; WORLD LIST MEMORY TEST; WORLD LIST RECALL; WORLD LIST RECOGNITION; COGNITION DISORDERS; COHORT ANALYSIS; COMPLICATION; PSYCHOLOGICAL RATING SCALE; SEX DIFFERENTIATION; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AUSTRIA; COGNITION DISORDERS; COHORT STUDIES; FEMALE; HUMANS; MALE; NEUROPSYCHOLOGICAL TESTS; PSYCHIATRIC STATUS RATING SCALES; SEX DIFFERENTIATION;

EID: 84934269429     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-150188     Document Type: Article

References (43)

1. Coltheart M, Hull E, Slater D (1975) Sex differences in imagery and reading. Nature 253, 438-440.
2. Linn MC, Petersen AC (1985) Emergence and characterization of sex differences in spatial ability: A meta-analysis. Child Dev 56, 1479-1498.
3. Masters MS, Sanders B (1993) Is the gender difference in mental rotation disappearing? Behav Genet 23, 337-341.
4. Kimura D, Clarke PG (2002) Women's advantage on verbal memory is not restricted to concrete words. Psychol Rep 91, 1137-1142.
5. Mathuranath PS, George A, Cherian PJ, Alexander A, Sarma SG, Sarma PS (2003) Effects of age, education and gender on verbal fluency. J Clin Exp Neuropsychol 25, 1057-1064.
6. van Hooren SA, Valentijn AM, Bosma H, Ponds RW, van Boxtel MP, Jolles J (2007) Cognitive functioning in healthy older adults aged 64-81: A cohort study into the effects of age, sex, and education. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 14, 40-54.
7. van Exel E, Gussekloo J, de Craen AJ, Bootsma-van der Wiel A, Houx P, Knook DL, Westendorp RG (2001) Cognitive function in the oldest old: Women perform better than men. J Neurol Neurosurg Psychiatry 71, 29-32.
8. Herlitz A, Nilsson LG, Backman L (1997) Gender differences in episodic memory. Mem Cogn 25, 801-811.
9. de Frias CM, Nilsson LG, Herlitz A (2006) Sex differences in cognition are stable over a 10-year period in adulthood and old age. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 13, 574-587.
10. Buckwalter JG, Sobel E, Dunn ME, Diz MM, Henderson VW (1993) Gender differences on a brief measure of cognitive functioning in Alzheimer's disease. Arch Neurol 50, 757-760.
11. Mortimer JA, Ebbitt B, Jun SP, Finch MD (1992) Predictors of cognitive and functional progression in patients with probable Alzheimer's disease. Neurology 42, 1689-1696.
12. McPherson S, Back C, Buckwalter JG, Cummings JL (1999) Gender-related cognitive deficits in Alzheimer's disease. Int Psychogeriatr 11, 117-122.
13. Chapman RM, Mapstone M, Gardner MN, Sandoval TC, McCrary JW, Guillily MD, Reilly LA, DeGrush E (2011) Women have farther to fall: Gender differences between normal elderly and Alzheimer's disease in verbal memory engender better detection of Alzheimer's disease in women. J Int Neuropsychol Soc 17, 654-662.
14. Marra C, Ferraccioli M, Gainotti G (2007) Gender-related dissociations of categorical fluency in normal subjects and in subjects with Alzheimer's disease. Neuropsychology 21, 207-211.
15. Ripich DN, Petrill SA, Whitehouse PJ, Ziol EW (1995) Gender differences in language of AD patients: A longitudinal study. Neurology 45, 299-302.
16. Pusswald G, Moser D, Gleiss A, Janzek-Hawlat S, Auff E, Dal-Bianco P, Lehrner J (2013) Prevalence of mild cognitive impairment subtypes in patients attending a memory outpatient clinic-comparison of two modes of mild cognitive impairment classification. Results of the Vienna Conversion to Dementia Study. Alzheimers Dement 9, 366-376.
17. Bao AM, Swaab DF (2011) Sexual differentiation of the human brain: Relation to gender identity, sexual orientation and neuropsychiatric disorders. Front Neuroendocrinol 32, 214-226.
18. Artero S, Ancelin ML, Portet F, Dupuy A, Berr C, Dartigues JF, Tzourio C, Rouaud O, Poncet M, Pasquier F, Auriacombe S, Touchon J, Ritchie K (2008) Risk profiles for mild cognitive impairment and progression to dementia are gender specific. J Neurol Neurosurg Psychiatry 79, 979-984.
19. American Psychiatric Association. (2000) Diagnostic and Statistical Manual of Mental Disorders, 4th ed. American Psychiatric Association, Washington DC.
20. Dubois B, Feldman HH, Jacova C, Dekosky ST, Barberger-Gateau P, Cummings J, Delacourte A, Galasko D, Gauthier S, Jicha G, Meguro K, O'Brien J, Pasquier F, Robert P, Rossor M, Salloway S, Stern Y, Visser PJ, Scheltens P (2007) Research criteria for the diagnosis of Alzheimer's disease: Revising the NINCDS-ADRDA criteria. Lancet Neurol 6, 734-746.
21. Berres M, Monsch AU, Bernasconi F, Thalmann B, Stahelin HB (2000) Normal ranges of neuropsychological tests for the diagnosis of Alzheimer's disease. Stud Health Technol Inform 77, 195-199.
22. Morris JC, Heyman A, Mohs RC, Hughes JP, van Belle G, Fillenbaum G, Mellits ED, Clark C (1989) The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer's disease. Neurology 39, 1159-1165.
23. Aebi C (2002) Validierung der neuropsychologischen Test-batterie CERAD-NP Eine Multi-Center Studie, Basel, Basel.
24. Bach M, Nikolaus T, Oster P, Schlierf G (1995) Depres-sionsdiagnostik im Alter. Die "Geriatric Depression Scale". Z Gerontol Geriatr 28, 42-46.
25. Cohen D, Eisdorfer C, Gorelick P, Luchins D, Freels S, Semla T, Paveza G, Shaw H, Ashford JW (1993) Sex differences in the psychiatric manifestations of Alzheimer's disease. J Am Geriatr Soc 41, 229-232.
26. Ott BR, Tate CA, Gordon NM, Heindel WC (1996) Gender differences in the behavioral manifestations of Alzheimer's disease. J Am Geriatr Soc 44, 583-587.
27. Bai F, Zhang Z, Watson DR, Yu H, Shi Y, Zhu W, Wang L, Yuan Y, Qian Y (2009) Absent gender differences of hippocampal atrophy in amnestic type mild cognitive impairment. Neurosci Lett 450, 85-89.
28. Henderson VW, Buckwalter JG (1994) Cognitive deficits of men and women with Alzheimer's disease. Neurology 44, 90-96.
29. Benke T, Delazer M, Sanin G, Schmidt H, Seiler S, Rans-mayr G, Dal-Bianco P, Uranus M, Marksteiner J, Leblhuber F, Kapeller P, Bancher C, Schmidt R (2013) Cognition, gender, and functional abilities in Alzheimer's disease: How are they related? J Alzheimers Dis 35, 247-252.
30. Hebert LE, Wilson RS, Gilley DW, Beckett LA, Scherr PA, Bennett DA, Evans DA (2000) Decline of language among women and men with Alzheimer's disease. J Gerontol B Psychol Sci Soc Sci 55, P354-P360.
31. Bayles KA, Azuma T, Cruz RF, Tomoeda CK, Wood JA, Montgomery EB Jr (1999) Gender differences in language of Alzheimer disease patients revisited. Alzheimer Dis Assoc Disord 13, 138-146.
32. Herholz K, Schopphoff H, Schmidt M, Mielke R, Eschner W, Scheidhauer K, Schicha H, Heiss WD, Ebmeier K (2002) Direct comparison of spatially normalized PET and SPECT scans in Alzheimer's disease. J Nucl Med 3, 21-26.
33. Kidron D, Black SE, Stanchev P, Buck B, Szalai JP, Parker J, Szekely C, Bronskill MJ (1997) Quantitative MR volumetry in Alzheimer's disease. Topographic markers and the effects of sex and education. Neurology 49, 1504-1512.
34. Callen DJ, Black SE, Gao F, Caldwell CB, Szalai JP (2001) Beyond the hippocampus: MRI volumetry confirms widespread limbic atrophy in AD. Neurology 57, 1669-1674.
35. Ballmaier M, O'Brien JT, Burton EJ, Thompson PM, Rex DE, Narr KL, McKeith IG, DeLuca H, Toga AW (2004) Comparing gray matter loss profiles between dementia with Lewy bodies and Alzheimer's disease using cortical pattern matching: Diagnosis and gender effects. Neuroimage 23, 325-335.
36. Callen DJ, Black SE, Caldwell CB, Grady CL (2004) The influence of sex on limbic volume and perfusion in AD. Neurobiol Aging 25, 761-770.
37. Kim EJ, Cho SS, Jeong Y, Park KC, Kang SJ, Kang E, Kim SE, Lee KH, Na DL (2005) Glucose metabolisminearly onset versus lateonsetAlzheimer'sdisease: An SPM analysisof120 patients. Brain 128, 1790-1801.
38. Fleisher A, Grundman M, Jack CR Jr, Petersen RC, Taylor C, Kim HT, Schiller DH, Bagwell V, Sencakova D, Weiner MF, DeCarli C, DeKosky ST, van Dyck CH, Thal LJ (2005) Sex, apolipoprotein E epsilon 4 status, and hippocam-pal volume in mild cognitive impairment. Arch Neurol 62, 953-957.
39. Karch CM, Goate AM (2015) Alzheimer's disease risk genes and mechanisms of disease pathogenesis. Biol Psychiatry 77, 43-51.
40. Karch CM, Cruchaga C, Goate AM (2014) Alzheimer's disease genetics: From the bench to the clinic. Neuron 83, 11-26.
41. Henderson VW, Watt L, Buckwalter JG (1996) Cognitive skills associated with estrogen replacement in women with Alzheimer's disease. Psychoneuroendocrinology 21, 421-430.
42. Perneczky R, Diehl-Schmid J, Forstl H, Drzezga A, Kurz A (2007) Male gender is associated with greater cerebral hypometabolism in frontotemporal dementia: Evidence for sex-related cognitive reserve. Int J Geriatr Psychiatry 22, 1135-1140.
43. Perneczky R, Drzezga A, Diehl-Schmid J, Li Y, Kurz A (2007) Gender differences in brain reserve: An (18)F-FDG PET study in Alzheimer's disease. J Neurol 254, 1395-1400.