DBS in the baso-lateral Amygdala improves symptoms of autism and related self-injurious behavior: A case report and hypothesis on the pathogenesis of the disorder

Frontiers in Human Neuroscience

Volumn , Issue DEC, 2012, Pages

  Sturm, V ^a   Fricke, O ^a   Buhrle C P ^a   Lenartz, D ^a   Maarouf, M ^a   Treuer, H ^a   Mai, J K ^b   Lehmkuhl, G ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Amygdala; Autism; Deep brain stimulation; Self injurious behavior

Indexed keywords

ARIPIPRAZOLE; LORAZEPAM; RISPERIDONE; TOPIRAMATE;

ADOLESCENT; ARTICLE; AUTISM; AUTOMUTILATION; BASOLATERAL AMYGDALA; BRAIN DEPTH STIMULATION; CASE REPORT; CLINICAL FEATURE; COGNITION; DISEASE SEVERITY; DRUG WITHDRAWAL; ELECTRODE; EMOTION; FOLLOW UP; HEMISPHERE; HUMAN; MALE; PATHOGENESIS; SOCIAL BEHAVIOR; SYMPTOM; TREATMENT RESPONSE;

EID: 84933678639     PISSN: 16625161     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnhum.2012.00341     Document Type: Article

References (59)

1. Akert K (1961): Diencephalon. In: Sheer (ed.): Electrical Stimulation of the Brain. Austin (Texas), 288-310.
2. Alheid GF, Heimer L (1988): New perspectives in basal forebrain organization of special relevance for neuropsychiatric disorders: the striatopallidal, amygdaloid, and corticopetal components of substantia innominata. Neuroscience 27 (1): 1-39 39
3. Amaral DG, Bauman MD, Schumann CM (2003): The amygdala and autism: implications from non-human primate studies. Genes Brain Behav 2(5): 295-302
4. Baird HW 3rd, Spiegel EA, Wycis (1960): Confin Neurol 20: 26-36
5. Bachevalier J (1994): Medial temporal lobe structures and autism: a review of clinical and experimental findings. Neuropsychologia. 32(6):627-648
6. Bachevalier J (2006): The amygdala, social cognition and autism. In: Aggleton JP (ed.)., The Amygdala, second edition, a functional analysis. Oxford University Press
7. Baron-Cohen S, Ring HA, Bullmore ET, Wheelwright S, Ashwin C, Williams SC. (2000): The amygdala theory of autism. Neurosci Biobehav Rev. 24(3): 355-364
8. Benabid AL, Chabardes S, Mitrofanis J, Pollak P (2009): Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease. Lancet Neurol Jan; 8(1): 67-81
9. Benabid AL, Koudsie A, Benazzouz A, Vercueil L, Fraix V, Chabardes S, Lebas JF, Pollak P (2001); Deep brain stimulation of the corpus luysi (subthalamic nucleus) and other targets in Parkinson's disease. Extension to new indications such as dystonia and epilepsy. J Neurol Sep: 248 Suppl 3: III 37-47
10. Benabid AL, Pollak P, Gross C, Hoffmann D, Benazzouz A, Gao DM, Laurent A, Gentil M, Perret J (1994): Acute and long-term effects of subthalamic nucleus stimulation in Parkinson's disease. Stereotact Funct Neurosurg 62(1-4): 76-84
11. Borthwick-Duffy SA (1994): Epidemiology and prevalence of psychopathology in people with mental retardation. J Consult Clin Psychol. 1994 Feb; 62(1):17-27.
12. Brockhaus H. (1938): Zur normalen und pathologischen Anatomie des Mandelkerngebietes J Psychol Neurol 49. 1-136 (Pdf: http://www.thehumanbrain.info/database/literature.php)
13. Constantino J, Gruber, C (2005): The social responsiveness scale. Western Psychological Services
14. Davis M, Whalen PJ (2001): The amygdala: vigilance and emotion. Mol Psychiatry 6: 13-34
15. Derwinska K, Smyk M, Cooper ML, Bader P, Cheung SW, Stankiewicz P (2009): PTCH1 duplication in a family with microcephaly and mild developmental delay. Eur. J Hum Genet. Feb; 17 (2): 267-271. Epub 2008 Oct. 1
16. Falconer MA, Serafetinidis EA, Corsellis JAN (1964): Etiology and pathogenesis of temporal lobe epilepsy. Arch. Neurol. (Chic.) 10, 233-248
17. Fernandez de Molina A, Hunsperger RW (1959): Central representation of affective reactions in forebrain and brain stem: electrical stimulation of amygdale, stria terminalis and adjacent structures. J Physiol; 145(2): 251-65.
18. Freese JL and Amaral DG (2009): Neuroanatomy of the primate amygdala. In: The Human amygdala (Eds. Whalen PJ and Phelps EA). pp. 3-42. The Guilford Press, New York, London
19. Guy W (1976): ECDEU Assessment Manual for Psychopharmacology Revised (DHEW Publ. No. ADM 76-338). Rockville, MD, U.S. Department of Health, Education and Welfare, Public Health Service, Alcohol, Drug Abuse and Mental Health Administration, NIMH Psychopharmacology Research Branch, Division of Extramural Research Programs: 218-222
20. Harkin LA, Bowser DN, Dibbens LM, Singh R, Phillips F, Wallace RH, Richards MC, Williams DA, Mulley JC, Hensch TK, Fagiolini M, Mataga N, Stryker MP, Baekkeskov S, Kash SF (1998): Local GABA circuit control of experience dependent plasticity in developing visual cortex. Science 282: 1504-1508
21. Hensch TK, Mataga N, Stryker MP, Baekkeskov S, Kash SF (1998): Local GABA circuit control of experience-dependent plasticity in developing visual cortex. Science 20; 282(5393): 1504-1508.
22. Hussman, JP (2001): Suppressed GABAergic inhibition as a common factor in suspected etiologies of autism. J Autism Dev Disord 2: 247-248
23. Jamain S, Betancur C, Quach H, Philippe A, Fellous M, Giros B, Gillberg C, Leboyer M, Bourgeron T; Paris Autism Research International Sibpair (PARIS) Study (2002). Linkage and association of the glutamate receptor 6 gene with autism. Mol Psychiatry; 7(3): 302-310.
24. Lang EJ, Pare D (1997): Similar inhibitory processes dominate the responses of cat lateral amygdaloid projection neurons to their various afferents. J Neurophysiol 77: 341-352
25. Lang EJ, Pare D (1998): Synaptic responsiveness of interneurons of the cat lateral amygdaloid nucleus. Neuroscience 83: 877-889
26. LeDoux, JE (2003): The Emotional Brain, Fear, and the amygdala. Cellular and Molecular Neurobiology 23: 727-738
27. Le Jeune F, Péron J, Grandjean D, Drapier S, Haegelen C, Garin E, Millet B, Vérin M (2010): Subthalamic nucleus stimulation affects limbic and associative circuits: a PET study. Eur J Nucl Med Mol Imaging 37: 1512-1520
28. Löchel D (2007): Morphologische multimodale Bildanpassung. Diplomarbeit, Mathematisches Institut, Universität Düsseldorf
29. Lord C, Rutter M, Le Couteur A (1994): Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord; 24(5): 659-85.
30. Lord C, Cook EH, Leventhal BL, Amaral DG (2000): Autism spectrum disorders. Neuron; 28(2): 355-63.
31. Lucywek E, Mempel E: Stereotactic amygdalotomy in the light of neurophysiological investigations. Acta Neurochir (Wien) Suppl. 23: 221-223
32. Mai JK, Paxinos G, Voss T (2008): Atlas of the Human Brain. 3rd Ed. Academic Press/Elsevier, San Diego
33. Markram K, Rinaldi T, La Mendola D, Sandi C, Markram H (2008): Abnormal Fear Conditioning and amygdala Processing in an Animal Model of Autism. Neuropsychopharmacology 33, 901-912
34. Markram K, Markram H (2010): The intense world theory - a unifying theory of the neurobiology of autism. Front Hum Neurosci 4 (224): 1-29
35. McIntyre RS (2011): Striving towards euthymia with a novel mechanism of action. J Affect Disord; 128 Suppl 1: S1-2.
36. Mempel E, Witkiewicz B, Stadnicki R, Luczywek E, Kucinsky L, Pawlowski G, Jurkiewicz J, Nowak J (1979): The effect of amygdalotomy and anterior hippocampotomy on behaviour and seizures in epileptic patients. 4th meeting of the European Society for Stereotactic and Functional Neurosurgery, Book of Abstracts, Paris
37. Morozov A, Sukato D, Wataro I (2011): Selective Suppression of Plasticity in amygdale Inputs from Temporal Association Cortex by the External Capsule. J Neurosci 30; ePub ahead of print
38. Narabayashi H, Nagao T, Saito G, Yoshida M, Nagahata M (1963): Stereotaxic amygdalotomy for behavior disorders. Arch Neurol (Chir.) 9, 11-26
39. Narabayashi H, Uno M (1966): Long range results of Stereotaxic amygdalotomy for behavior disorders. Confin Neurol 27(1): 168-171
40. Narabayashi H (1970) Amygdaloid surgery in epileptic seizures. In: Umbach W (ed.). Special topics in stereotaxis-Epilepsy, disorders of behaviour and autonomic balance. Hippokrates, Stuttgart, 65-68
41. Narabayashi H (1979): From experiences of amygdalotomy on epileptics. 4th meeting of the European Society for Stereotactic and Functional Neurosurgery, Book of Abstracts, Paris
42. Nuttin B, Cosyns P, Demeulemeester H, Gybels J, Meyerson B (1999): Electrical Stimulation in anterior limbs of internal capsule in patients wit obsessive-compulsive disorder. Lancet, Oct. 30, (354) 9189: 1526
43. Oya, H, Kawasaki, H, Dahdaleh, NS, Wemmie, JA, Howard III, MA (2009): Stereotactic Atlas-Based Depth Electrode Localization in the Human amygdala. Stereotactic and Functional Neurosurgery 87(4): 219-228.
44. Péron J, Le Jeune F, Haegelen C, Dondaine T, Drapier D, Sauleau P, Reymann JM, Drapier S, Rouaud T, Millet B, Vérin M (2010): Subthalamic Nucleus Stimulation Affects Theory of Mind Network. A PET study in Parkinson's Disease. PloS one, 5(3), e9919: 1-9
45. Pessoa L, Adolphs R (2010): Emotion processing and the amygdala: from a 'low road' to 'many roads' of evaluating biological significance. Nat Rev Neurosci; 11(11): 773-83.
46. Phelps, EA (2006): Emotion and cognition: Insights from studies of the human amygdala. Annual Review of Psychology 24 (57): 27-53
47. Popescu AT, Popa D, Paré D (2009): Coherent gamma oscillations couple the amygdala and striatum during learning. Nat Neurosci 12(6): 801-807
48. Racine R (1978): Kindling, the first decade. Neurosurg. 3, No. 2, 234-252
49. Rubenstein JLR, Merzenich MM (2003): Model of autism: increased ratio of excitation/inhibition in key neural systems. Genes, Brain and Behavior 2: 255-267
50. Rutter M, LeCouteur A, Lord C (2006): Autism Diagnostic Interview-Revised (ADI-R). Translated Version by Bölte S, Rühl D, Schmötzer G, Poustka F. Hogreve, Verlag Hans Huber, Bern, Schweiz
51. Sander D, Grafman J, Zalla T (2003): The human amygdala: an evolved system for relevance detection. Rev. Neurosci. 14(4):303-316
52. Santos A, Mier D, Kirsch P, Meyer-Lindenberg A (2011): Evidence for a general face salience in human amygdala. Neuroimage 14; 54(4): 3111-3116. Epub 2010 Nov 21
53. Schroeder S, Oster-Granite M, Berkson G, Bodfish J, Breese G, Cataldo M, Cook G, Crnic L, DeLeon I, Fisher W, Harris J, Horner R, Iwata B, Jinnah H, King B Lauder J, Lewis M, Newell K, Nyhan W, Rojahn J, Sackett G, Sandman C, Symons F, Tessel R, Thompson T, Wong D (2001): Self-injurious behavior: gene-brain-behavior relationships. Ment Retard Dev Disabil Res Rev 17:3-12
54. Schuler, V, Luscher, C, Blanchet, C, Klix, N, Sansig, G, Klebs, K, Schmutz, M, Heid, J, Gentry, C, Urban, L, Fox, A, Spooren, W, Jaton, AL, Vigouret, J, Pozza, M, Kelly, PH, Mosbacher, J, Froestl, W, Kaslin, E, Korn, R, Bischoff, S, Kaupmann, K, van der Putten, H, Bettler, B (2001): Epilepsy, hyperalgesia, impaired memory, and loss of pre-and postsynaptic GABA (B) responses in mice lacking GABA (B (1)). Neuron 31: 47-58
55. Schumann CM, Baumann MD, Machado CJ, Amaral DG (2006): The social brain, amygdala and autism. In Moldin SO, Rubenstein JLR (eds.) Understanding autism, CRC Press, Taylor and Francis Group, Boca Raton, FL.
56. State MW (2010): The genetics of child psychiatric disorders: focus on autism and Tourette syndrome. Neuron 68 (2): 254-69
57. Voges J, Volkmann J, Allert N, Lehrke R, Koulousakis A, Freund HJ, Sturm V (2002): Bilateral high-frequency stimulation in the subthalamic nucleus fort the treatment of Parkinson disease: correlation of the therapeutic effect with anatomical electrode position. J. Neurosurg 96(2): 269- 279
58. Yilmazer-Hanke DM, Faber-Zumschratter H, Blümcke I, Bickel M, Becker A, Mawrin C, Schramm J (2007): Axo-somatic inhibition of projection neurons in the lateral nucleus of amygdala in human temporal lobe epilepsy: an ultrastructural study. Exp Brain Res. 177: 384-99
59. Yilmazer-Hanke DM: amygdala. In: JK Mai and G Paxinos (Eds.) The Human Nervous System. 3rd ed.; Elsevier (in press)