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Volumn 152, Issue , 2015, Pages 18-27

Idiopathic pulmonary fibrosis: Recent advances on pharmacological therapy

Author keywords

Clinical trials; Idiopathic pulmonary fibrosis; Nintedanib; Pirfenidone; Therapy; Treatment

Indexed keywords

ACETYLCYSTEINE; ANTIFIBROTIC AGENT; AZATHIOPRINE; NINTEDANIB; PIRFENIDONE; PREDNISONE; WARFARIN; INDOLE DERIVATIVE; NONSTEROID ANTIINFLAMMATORY AGENT; PYRIDONE DERIVATIVE;

EID: 84933675401     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2015.04.005     Document Type: Review
Times cited : (77)

References (69)
  • 1
    • 20944434994 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled trial of pirfenidone in patients with idiopathic pulmonary fibrosis
    • A. Azuma, T. Nukiwa, E. Tsuboi, M. Suga, S. Abe, and K. Nakata Double-blind, placebo-controlled trial of pirfenidone in patients with idiopathic pulmonary fibrosis Am J Respir Crit Care Med 171 2005 1040 1047
    • (2005) Am J Respir Crit Care Med , vol.171 , pp. 1040-1047
    • Azuma, A.1    Nukiwa, T.2    Tsuboi, E.3    Suga, M.4    Abe, S.5    Nakata, K.6
  • 2
    • 0031449645 scopus 로고    scopus 로고
    • Antioxidative and clinical effects of high-dose N-acetylcysteine in fibrosing alveolitis. Adjunctive therapy to maintenance immunosuppression
    • J. Behr, K. Maier, B. Degenkolb, F. Krombach, and C. Vogelmeier Antioxidative and clinical effects of high-dose N-acetylcysteine in fibrosing alveolitis. Adjunctive therapy to maintenance immunosuppression Am J Respir Crit Care Med 156 1997 1897 1901
    • (1997) Am J Respir Crit Care Med , vol.156 , pp. 1897-1901
    • Behr, J.1    Maier, K.2    Degenkolb, B.3    Krombach, F.4    Vogelmeier, C.5
  • 4
    • 0024578662 scopus 로고
    • Glutathione deficiency in the epithelial lining fluid of the lower respiratory tract in idiopathic pulmonary fibrosis
    • A.M. Cantin, R.C. Hubbard, and R.G. Crystal Glutathione deficiency in the epithelial lining fluid of the lower respiratory tract in idiopathic pulmonary fibrosis Am Rev Respir Dis 139 1989 370 372
    • (1989) Am Rev Respir Dis , vol.139 , pp. 370-372
    • Cantin, A.M.1    Hubbard, R.C.2    Crystal, R.G.3
  • 6
    • 77951171086 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis and pirfenidone
    • H.R. Collard Idiopathic pulmonary fibrosis and pirfenidone Eur Respir J 35 2010 728 729
    • (2010) Eur Respir J , vol.35 , pp. 728-729
    • Collard, H.R.1
  • 10
    • 84899830690 scopus 로고    scopus 로고
    • 6-minute walk test distance is an independent predictor of mortality in patients with idiopathic pulmonary fibrosis
    • R.M. du Bois, C. Albera, W.Z. Bradford, U. Costabel, J.A. Leff, and P.W. Noble 6-minute walk test distance is an independent predictor of mortality in patients with idiopathic pulmonary fibrosis Eur Respir J 43 2014 1421 1429
    • (2014) Eur Respir J , vol.43 , pp. 1421-1429
    • Du Bois, R.M.1    Albera, C.2    Bradford, W.Z.3    Costabel, U.4    Leff, J.A.5    Noble, P.W.6
  • 11
    • 84865112235 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis: Lung function is a clinically meaningful endpoint for phase III trials
    • R.M. du Bois, S.D. Nathan, L. Richeldi, M.I. Schwarz, and P.W. Noble Idiopathic pulmonary fibrosis: lung function is a clinically meaningful endpoint for phase III trials Am J Respir Crit Care Med 186 2012 712 715
    • (2012) Am J Respir Crit Care Med , vol.186 , pp. 712-715
    • Du Bois, R.M.1    Nathan, S.D.2    Richeldi, L.3    Schwarz, M.I.4    Noble, P.W.5
  • 12
    • 84455168726 scopus 로고    scopus 로고
    • Forced vital capacity in patients with idiopathic pulmonary fibrosis: Test properties and minimal clinically important difference
    • R.M. du Bois, D. Weycker, C. Albera, W.Z. Bradford, U. Costabel, and A. Kartashov Forced vital capacity in patients with idiopathic pulmonary fibrosis: test properties and minimal clinically important difference Am J Respir Crit Care Med 184 2011 1382 1389
    • (2011) Am J Respir Crit Care Med , vol.184 , pp. 1382-1389
    • Du Bois, R.M.1    Weycker, D.2    Albera, C.3    Bradford, W.Z.4    Costabel, U.5    Kartashov, A.6
  • 13
    • 79955520497 scopus 로고    scopus 로고
    • Six-minute-walk test in idiopathic pulmonary fibrosis: Test validation and minimal clinically important difference
    • R.M. du Bois, D. Weycker, C. Albera, W.Z. Bradford, U. Costabel, and A. Kartashov Six-minute-walk test in idiopathic pulmonary fibrosis: test validation and minimal clinically important difference Am J Respir Crit Care Med 183 2011 1231 1237
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 1231-1237
    • Du Bois, R.M.1    Weycker, D.2    Albera, C.3    Bradford, W.Z.4    Costabel, U.5    Kartashov, A.6
  • 14
    • 84857433316 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis: Phenotypes and comorbidities
    • C.D. Fell Idiopathic pulmonary fibrosis: phenotypes and comorbidities Clin Chest Med 33 2012 51 57
    • (2012) Clin Chest Med , vol.33 , pp. 51-57
    • Fell, C.D.1
  • 16
    • 49649123154 scopus 로고    scopus 로고
    • BIBF 1120: Triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy
    • F. Hilberg, G.J. Roth, M. Krssak, S. Kautschitsch, W. Sommergruber, and U. Tontsch-Grunt BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy Cancer Res 68 2008 4774 4782
    • (2008) Cancer Res , vol.68 , pp. 4774-4782
    • Hilberg, F.1    Roth, G.J.2    Krssak, M.3    Kautschitsch, S.4    Sommergruber, W.5    Tontsch-Grunt, U.6
  • 17
    • 84928655120 scopus 로고    scopus 로고
    • Anti-fibrotic effects of nintedanib in lung fibroblasts derived from patients with idiopathic pulmonary fibrosis
    • (Epub ahead of print)
    • K.E. Hostettler, J. Zhong, E. Papakonstantinou, G. Karakiulakis, M. Tamm, and P. Seidel Anti-fibrotic effects of nintedanib in lung fibroblasts derived from patients with idiopathic pulmonary fibrosis Respir Res 15 2014 157 (Epub ahead of print)
    • (2014) Respir Res , vol.15 , pp. 157
    • Hostettler, K.E.1    Zhong, J.2    Papakonstantinou, E.3    Karakiulakis, G.4    Tamm, M.5    Seidel, P.6
  • 18
    • 0014145811 scopus 로고
    • Laboratory and clinical evaluation of the mucolytic properties of acetylcysteine
    • G.A. Hurst, P.B. Shaw, and C.A. LeMaistre Laboratory and clinical evaluation of the mucolytic properties of acetylcysteine Am Rev Respir Dis 96 1967 962 970
    • (1967) Am Rev Respir Dis , vol.96 , pp. 962-970
    • Hurst, G.A.1    Shaw, P.B.2    Lemaistre, C.A.3
  • 19
    • 84861394764 scopus 로고    scopus 로고
    • Prednisone, azathioprine, and N-acetylcysteine for pulmonary fibrosis
    • Idiopathic Pulmonary Fibrosis Clinical Research Network
    • Idiopathic Pulmonary Fibrosis Clinical Research Network, F.J. Martinez, J.A. de Andrade, K.J. Anstrom, T.E. King Jr., and G. Raghu Prednisone, azathioprine, and N-acetylcysteine for pulmonary fibrosis N Engl J Med 366 2012 1968 1977
    • (2012) N Engl J Med , vol.366 , pp. 1968-1977
    • Martinez, F.J.1    De Andrade, J.A.2    Anstrom, K.J.3    King, Jr.T.E.4    Raghu, G.5
  • 20
    • 84901746607 scopus 로고    scopus 로고
    • Randomized trial of acetylcysteine in idiopathic pulmonary fibrosis
    • Idiopathic Pulmonary Fibrosis Clinical Research Network
    • Idiopathic Pulmonary Fibrosis Clinical Research Network, F.J. Martinez, J.A. de Andrade, K.J. Anstrom, T.E. King Jr., and G. Raghu Randomized trial of acetylcysteine in idiopathic pulmonary fibrosis N Engl J Med 370 2014 2093 2101
    • (2014) N Engl J Med , vol.370 , pp. 2093-2101
    • Martinez, F.J.1    De Andrade, J.A.2    Anstrom, K.J.3    King, Jr.T.E.4    Raghu, G.5
  • 21
    • 77956640423 scopus 로고    scopus 로고
    • A controlled trial of sildenafil in advanced idiopathic pulmonary fibrosis
    • Idiopathic Pulmonary Fibrosis Clinical Research Network, D.A. Zisman, M. Schwarz, K.J. Anstrom, H.R. Collard, and K.R. Flaherty A controlled trial of sildenafil in advanced idiopathic pulmonary fibrosis N Engl J Med 363 2010 620 628
    • (2010) N Engl J Med , vol.363 , pp. 620-628
    • Zisman, D.A.1    Schwarz, M.2    Anstrom, K.J.3    Collard, H.R.4    Flaherty, K.R.5
  • 22
    • 0032842405 scopus 로고    scopus 로고
    • Effects of pirfenidone on transforming growth factor-b gene expression at the transcriptional level in bleomycin hamster model of lung fibrosis
    • S.N. Iyer, G. Gurujeyalakshmi, and S.N. Giri Effects of pirfenidone on transforming growth factor-b gene expression at the transcriptional level in bleomycin hamster model of lung fibrosis J Pharmacol Exp Ther 291 1999 367 373
    • (1999) J Pharmacol Exp Ther , vol.291 , pp. 367-373
    • Iyer, S.N.1    Gurujeyalakshmi, G.2    Giri, S.N.3
  • 23
    • 3543071795 scopus 로고    scopus 로고
    • Pirfenidone attenuates expression of HSP47 in murine bleomycin-induced pulmonary fibrosis
    • T. Kakugawa, H. Mukae, T. Hayashi, H. Ishii, K. Abe, and T. Fujii Pirfenidone attenuates expression of HSP47 in murine bleomycin-induced pulmonary fibrosis Eur Respir J 24 2004 57 65
    • (2004) Eur Respir J , vol.24 , pp. 57-65
    • Kakugawa, T.1    Mukae, H.2    Hayashi, T.3    Ishii, H.4    Abe, K.5    Fujii, T.6
  • 24
    • 74549213651 scopus 로고    scopus 로고
    • Trial and error: How to avoid commonly encountered limitations of published clinical trials
    • S. Kaul, and G.A. Diamond Trial and error: how to avoid commonly encountered limitations of published clinical trials J Am Coll Cardiol 55 2010 415 427
    • (2010) J Am Coll Cardiol , vol.55 , pp. 415-427
    • Kaul, S.1    Diamond, G.A.2
  • 25
    • 84897459884 scopus 로고    scopus 로고
    • All-cause mortality rate in patients with idiopathic pulmonary fibrosis. Implications for the design and execution of clinical trials
    • T.E. King, C. Albera, W.Z. Bradford, U. Costabel, R.M. du Bois, and J.A. Leff All-cause mortality rate in patients with idiopathic pulmonary fibrosis. Implications for the design and execution of clinical trials Am J Respir Crit Care Med 189 2014 825 831
    • (2014) Am J Respir Crit Care Med , vol.189 , pp. 825-831
    • King, T.E.1    Albera, C.2    Bradford, W.Z.3    Costabel, U.4    Du Bois, R.M.5    Leff, J.A.6
  • 26
    • 67650349068 scopus 로고    scopus 로고
    • Effect of interferon gamma-1b on survival in patients with idiopathic pulmonary fibrosis (INSPIRE): A multicentre, randomised, placebo-controlled trial
    • T.E. King Jr., C. Albera, W.Z. Bradford, U. Costabel, P. Hormel, and L. Lancaster Effect of interferon gamma-1b on survival in patients with idiopathic pulmonary fibrosis (INSPIRE): a multicentre, randomised, placebo-controlled trial Lancet 374 2009 222 228
    • (2009) Lancet , vol.374 , pp. 222-228
    • King, Jr.T.E.1    Albera, C.2    Bradford, W.Z.3    Costabel, U.4    Hormel, P.5    Lancaster, L.6
  • 30
    • 82755161052 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis
    • T.E. King Jr., A. Pardo, and M. Selman Idiopathic pulmonary fibrosis Lancet 378 2011 1949 1961
    • (2011) Lancet , vol.378 , pp. 1949-1961
    • King, Jr.T.E.1    Pardo, A.2    Selman, M.3
  • 34
    • 79951844263 scopus 로고    scopus 로고
    • Clinical course and prediction of survival in idiopathic pulmonary fibrosis
    • B. Ley, H.R. Collard, and T.E. King Jr. Clinical course and prediction of survival in idiopathic pulmonary fibrosis Am J Respir Crit Care Med 183 2011 431 440
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 431-440
    • Ley, B.1    Collard, H.R.2    King, Jr.T.E.3
  • 35
    • 77958165170 scopus 로고    scopus 로고
    • Pirfenidone in idiopathic pulmonary fibrosis
    • T.M. Maher Pirfenidone in idiopathic pulmonary fibrosis Drugs Today (Barc) 46 2010 473 482
    • (2010) Drugs Today (Barc) , vol.46 , pp. 473-482
    • Maher, T.M.1
  • 36
    • 84857433362 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis: Pathobiology and novel approaches to treatment
    • T.M. Maher Idiopathic pulmonary fibrosis: pathobiology and novel approaches to treatment Clin Chest Med 33 2012 69 83
    • (2012) Clin Chest Med , vol.33 , pp. 69-83
    • Maher, T.M.1
  • 37
    • 70049091181 scopus 로고    scopus 로고
    • Lost in translation; From animal models of pulmonary fibrosis to human disease
    • T.M. Maher, and A.U. Wells Lost in translation; from animal models of pulmonary fibrosis to human disease Respirology 14 2009 915 916
    • (2009) Respirology , vol.14 , pp. 915-916
    • Maher, T.M.1    Wells, A.U.2
  • 38
    • 38849178850 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis: Multiple causes and multiple mechanisms?
    • T.M. Maher, A.U. Wells, and G.J. Laurent Idiopathic pulmonary fibrosis: multiple causes and multiple mechanisms? Eur Respir J 30 2007 835 839
    • (2007) Eur Respir J , vol.30 , pp. 835-839
    • Maher, T.M.1    Wells, A.U.2    Laurent, G.J.3
  • 39
    • 79959886642 scopus 로고    scopus 로고
    • An investigator-driven study of everolimus in surgical lung biopsy confirmed idiopathic pulmonary fibrosis
    • M.A. Malouf, P. Hopkins, G. Snell, A.R. Glanville, and Everolimus in IPF Study Investigators An investigator-driven study of everolimus in surgical lung biopsy confirmed idiopathic pulmonary fibrosis Respirology 16 2011 776 783
    • (2011) Respirology , vol.16 , pp. 776-783
    • Malouf, M.A.1    Hopkins, P.2    Snell, G.3    Glanville, A.R.4
  • 41
    • 69149098551 scopus 로고    scopus 로고
    • N-acetylcysteine: Multiple clinical applications
    • P.J. Millea N-acetylcysteine: multiple clinical applications Am Fam Physician 80 2009 265 269
    • (2009) Am Fam Physician , vol.80 , pp. 265-269
    • Millea, P.J.1
  • 42
    • 39149103740 scopus 로고    scopus 로고
    • The bleomycin animal model: A useful tool to investigate treatment options for idiopathic pulmonary fibrosis?
    • A. Moeller, K. Ask, D. Warburton, J. Gauldie, and M. Kolb The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis? Int J Biochem Cell Biol 40 2008 362 382
    • (2008) Int J Biochem Cell Biol , vol.40 , pp. 362-382
    • Moeller, A.1    Ask, K.2    Warburton, D.3    Gauldie, J.4    Kolb, M.5
  • 43
    • 79960426037 scopus 로고    scopus 로고
    • Long-term course and prognosis of idiopathic pulmonary fibrosis in the new millennium
    • S.D. Nathan, O.A. Shlobin, N. Weir, S. Ahmad, J.M. Kaldjob, and E. Battle Long-term course and prognosis of idiopathic pulmonary fibrosis in the new millennium Chest 140 2011 221 229
    • (2011) Chest , vol.140 , pp. 221-229
    • Nathan, S.D.1    Shlobin, O.A.2    Weir, N.3    Ahmad, S.4    Kaldjob, J.M.5    Battle, E.6
  • 45
    • 0034520079 scopus 로고    scopus 로고
    • The prognostic significance of the histologic pattern of interstitial pneumonia in patients presenting with the clinical entity of cryptogenic fibrosing alveolitis
    • A.G. Nicholson, T.V. Colby, R.M. du Bois, D.M. Hansell, and A.U. Wells The prognostic significance of the histologic pattern of interstitial pneumonia in patients presenting with the clinical entity of cryptogenic fibrosing alveolitis Am J Respir Crit Care Med 162 2000 2213 2217
    • (2000) Am J Respir Crit Care Med , vol.162 , pp. 2213-2217
    • Nicholson, A.G.1    Colby, T.V.2    Du Bois, R.M.3    Hansell, D.M.4    Wells, A.U.5
  • 46
    • 79956341531 scopus 로고    scopus 로고
    • Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): Two randomised trials
    • P.W. Noble, C. Albera, W.Z. Bradford, U. Costabel, M.K. Glassberg, and D. Kardatzke Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): two randomised trials Lancet 377 2011 1760 1769
    • (2011) Lancet , vol.377 , pp. 1760-1769
    • Noble, P.W.1    Albera, C.2    Bradford, W.Z.3    Costabel, U.4    Glassberg, M.K.5    Kardatzke, D.6
  • 48
    • 48149113955 scopus 로고    scopus 로고
    • Antifibrotic action of pirfenidone and prednisolone: Different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis
    • H. Oku, T. Shimizu, T. Kawabata, M. Nagira, I. Hikita, and A. Ueyama Antifibrotic action of pirfenidone and prednisolone: different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis Eur J Pharmacol 590 2008 400 408
    • (2008) Eur J Pharmacol , vol.590 , pp. 400-408
    • Oku, H.1    Shimizu, T.2    Kawabata, T.3    Nagira, M.4    Hikita, I.5    Ueyama, A.6
  • 49
    • 84877297353 scopus 로고    scopus 로고
    • Treatment of idiopathic pulmonary fibrosis with ambrisentan: A parallel, randomized trial
    • G. Raghu, J. Behr, K.K. Brown, J.J. Egan, S.M. Kawut, and K.R. Flaherty Treatment of idiopathic pulmonary fibrosis with ambrisentan: a parallel, randomized trial Ann Intern Med 158 2013 641 649
    • (2013) Ann Intern Med , vol.158 , pp. 641-649
    • Raghu, G.1    Behr, J.2    Brown, K.K.3    Egan, J.J.4    Kawut, S.M.5    Flaherty, K.R.6
  • 50
    • 0345824715 scopus 로고    scopus 로고
    • A placebo-controlled trial of interferon gamma-1b in patients with idiopathic pulmonary fibrosis
    • G. Raghu, K.K. Brown, W.Z. Bradford, K. Starko, P.W. Noble, and D.A. Schwartz A placebo-controlled trial of interferon gamma-1b in patients with idiopathic pulmonary fibrosis N Engl J Med 350 2004 125 133
    • (2004) N Engl J Med , vol.350 , pp. 125-133
    • Raghu, G.1    Brown, K.K.2    Bradford, W.Z.3    Starko, K.4    Noble, P.W.5    Schwartz, D.A.6
  • 51
    • 55549147184 scopus 로고    scopus 로고
    • Treatment of idiopathic pulmonary fibrosis with etanercept: An exploratory, placebo-controlled trial
    • G. Raghu, K.K. Brown, U. Costabel, V. Cottin, R.M. du Bois, and J.A. Lasky Treatment of idiopathic pulmonary fibrosis with etanercept: an exploratory, placebo-controlled trial Am J Respir Crit Care Med 178 2008 948 955
    • (2008) Am J Respir Crit Care Med , vol.178 , pp. 948-955
    • Raghu, G.1    Brown, K.K.2    Costabel, U.3    Cottin, V.4    Du Bois, R.M.5    Lasky, J.A.6
  • 52
    • 84904006129 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis in US Medicare beneficiaries aged 65 years and older: Incidence, prevalence and survival, 2001-11
    • G. Raghu, S.-Y. Chen, W.-S. Yeh, B. Maroni, Q. Li, and Y.C. Lee Idiopathic pulmonary fibrosis in US Medicare beneficiaries aged 65 years and older: incidence, prevalence and survival, 2001-11 Lancet Respir Med 2 2014 566 572
    • (2014) Lancet Respir Med , vol.2 , pp. 566-572
    • Raghu, G.1    Chen, S.-Y.2    Yeh, W.-S.3    Maroni, B.4    Li, Q.5    Lee, Y.C.6
  • 53
    • 79952717349 scopus 로고    scopus 로고
    • An official ATS/ERS/JRS/ALAT statement: Idiopathic pulmonary fibrosis: Evidence-based guidelines for diagnosis and management
    • G. Raghu, H.R. Collard, J.J. Egan, F.J. Martinez, J. Behr, and K.K. Brown An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management Am J Respir Crit Care Med 183 2011 788 824
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 788-824
    • Raghu, G.1    Collard, H.R.2    Egan, J.J.3    Martinez, F.J.4    Behr, J.5    Brown, K.K.6
  • 54
    • 0032926937 scopus 로고    scopus 로고
    • Treatment of idiopathic pulmonary fibrosis with a new antifibrotic agent, pirfenidone: Results of a prospective, open-label Phase II study
    • G. Raghu, W.C. Johnson, D. Lockhart, and Y. Mageto Treatment of idiopathic pulmonary fibrosis with a new antifibrotic agent, pirfenidone: results of a prospective, open-label Phase II study Am J Respir Crit Care Med 159 1999 1061 1069
    • (1999) Am J Respir Crit Care Med , vol.159 , pp. 1061-1069
    • Raghu, G.1    Johnson, W.C.2    Lockhart, D.3    Mageto, Y.4
  • 55
    • 84888166435 scopus 로고    scopus 로고
    • Macitentan for the treatment of idiopathic pulmonary fibrosis: The randomised controlled MUSIC trial
    • G. Raghu, R. Million-Rousseau, A. Morganti, L. Perchenet, J. Behr, and MUSIC Study Group Macitentan for the treatment of idiopathic pulmonary fibrosis: the randomised controlled MUSIC trial Eur Respir J 42 2013 1622 1632
    • (2013) Eur Respir J , vol.42 , pp. 1622-1632
    • Raghu, G.1    Million-Rousseau, R.2    Morganti, A.3    Perchenet, L.4    Behr, J.5
  • 56
    • 80053091084 scopus 로고    scopus 로고
    • Efficacy of a tyrosine kinase inhibitor in idiopathic pulmonary fibrosis
    • L. Richeldi, U. Costabel, and M. Selman Efficacy of a tyrosine kinase inhibitor in idiopathic pulmonary fibrosis N Engl J Med 365 2011 1079 1087
    • (2011) N Engl J Med , vol.365 , pp. 1079-1087
    • Richeldi, L.1    Costabel, U.2    Selman, M.3
  • 59
    • 81755173974 scopus 로고    scopus 로고
    • Living with idiopathic pulmonary fibrosis: An in-depth qualitative survey of European patients
    • G. Schoenheit, I. Becattelli, and A.H. Cohen Living with idiopathic pulmonary fibrosis: an in-depth qualitative survey of European patients Chron Respir Dis 8 2011 225 231
    • (2011) Chron Respir Dis , vol.8 , pp. 225-231
    • Schoenheit, G.1    Becattelli, I.2    Cohen, A.H.3
  • 60
    • 33748305617 scopus 로고    scopus 로고
    • An official ATS statement: Grading the quality of evidence and strength of recommendations in ATS guidelines and recommendations
    • H.J. Schunemann, R. Jaeschke, D.J. Cook, W.F. Bria, A.A. El-Solh, and A. Ernst An official ATS statement: grading the quality of evidence and strength of recommendations in ATS guidelines and recommendations Am J Respir Crit Care Med 174 2006 605 614
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 605-614
    • Schunemann, H.J.1    Jaeschke, R.2    Cook, D.J.3    Bria, W.F.4    El-Solh, A.A.5    Ernst, A.6
  • 61
    • 84901022861 scopus 로고    scopus 로고
    • Revealing the pathogenic and aging-related mechanisms of the enigmatic idiopathic pulmonary fibrosis. An integral model
    • M. Selman, and A. Pardo Revealing the pathogenic and aging-related mechanisms of the enigmatic idiopathic pulmonary fibrosis. An integral model Am J Respir Crit Care Med 189 2014 1161 1172
    • (2014) Am J Respir Crit Care Med , vol.189 , pp. 1161-1172
    • Selman, M.1    Pardo, A.2
  • 62
    • 84872677109 scopus 로고    scopus 로고
    • Treating idiopathic pulmonary fibrosis with the addition of co-trimoxazole: A randomised controlled trial
    • L. Shulgina, A.P. Cahn, E.R. Chilvers, H. Parfrey, A.B. Clark, and E.C. Wilson Treating idiopathic pulmonary fibrosis with the addition of co-trimoxazole: a randomised controlled trial Thorax 68 2013 155 162
    • (2013) Thorax , vol.68 , pp. 155-162
    • Shulgina, L.1    Cahn, A.P.2    Chilvers, E.R.3    Parfrey, H.4    Clark, A.B.5    Wilson, E.C.6
  • 63
  • 65
    • 84900328026 scopus 로고    scopus 로고
    • Genetic determinants of pulmonary fibrosis: Evolving concepts
    • P. Spagnolo, J. Grunewald, and R.M. du Bois Genetic determinants of pulmonary fibrosis: evolving concepts Lancet Respir Med 2 2014 416 428
    • (2014) Lancet Respir Med , vol.2 , pp. 416-428
    • Spagnolo, P.1    Grunewald, J.2    Du Bois, R.M.3
  • 67
    • 84881669432 scopus 로고    scopus 로고
    • An official American Thoracic Society/European Respiratory Society statement: Update of the international multidisciplinary classification of the idiopathic interstitial pneumonias
    • W.D. Travis, U. Costabel, D.M. Hansell, T.E. King Jr., D.A. Lynch, and A.G. Nicholson An official American Thoracic Society/European Respiratory Society statement: update of the international multidisciplinary classification of the idiopathic interstitial pneumonias Am J Respir Crit Care Med 188 2013 733 748
    • (2013) Am J Respir Crit Care Med , vol.188 , pp. 733-748
    • Travis, W.D.1    Costabel, U.2    Hansell, D.M.3    King, Jr.T.E.4    Lynch, D.A.5    Nicholson, A.G.6
  • 68
    • 84903166926 scopus 로고    scopus 로고
    • Comprehensive assessment of the long-term safety of pirfenidone in patients with idiopathic pulmonary fibrosis
    • D. Valeyre, C. Albera, W.Z. Bradford, U. Costabel, T.E. King Jr., and J.A. Leff Comprehensive assessment of the long-term safety of pirfenidone in patients with idiopathic pulmonary fibrosis Respirology 19 2014 740 747
    • (2014) Respirology , vol.19 , pp. 740-747
    • Valeyre, D.1    Albera, C.2    Bradford, W.Z.3    Costabel, U.4    King, Jr.T.E.5    Leff, J.A.6
  • 69
    • 84898792564 scopus 로고    scopus 로고
    • Antifibrotic and anti-inflammatory activity of the tyrosine kinase inhibitor nintedanib in experimental models of lung fibrosis
    • L. Wollin, I. Maillet, V. Quesniaux, A. Holweg, and B. Ryffel Antifibrotic and anti-inflammatory activity of the tyrosine kinase inhibitor nintedanib in experimental models of lung fibrosis J Pharmacol Exp Ther 349 2014 209 220
    • (2014) J Pharmacol Exp Ther , vol.349 , pp. 209-220
    • Wollin, L.1    Maillet, I.2    Quesniaux, V.3    Holweg, A.4    Ryffel, B.5


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