An autologous endothelial cell: Peripheral blood mononuclear cell assay that detects cytokine storm responses to biologics

FASEB Journal

Volumn 29, Issue 6, 2015, Pages 2595-2602

  Reed, Daniel M ^a   Paschalaki, Koralia E ^a   Starke, Richard D ^a   Mohamed, Nura A ^a,b   Sharp, Giles ^c   Fox, Bernard ^c   Eastwood, David ^c   Bristow, Adrian ^c   Ball, Christina ^c   Vessillier, Sandrine ^c   Hansel, Trevor T ^d   Thorpe, Susan J ^c   Randi, Anna M ^a   Stebbings, Richard ^e   Mitchell, Jane A ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b Qatar Foundation Research and Development Division   (Qatar)

^c NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

^d ST MARY S HOSPITAL   (United Kingdom)

^e MEDIMMUNE   (United States)

Author keywords

Coculture; Personalized medicine; Stem cells; TGN1412

Indexed keywords

ALEMTUZUMAB; BEVACIZUMAB; OFATUMUMAB; TRASTUZUMAB; BIOLOGICAL PRODUCT; CULTURE MEDIUM; CYTOKINE; INTERLEUKIN 2; INTERLEUKIN 6; INTERLEUKIN 8; MONOCLONAL ANTIBODY; TGN-1412 MONOCLONAL ANTIBODY; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BIOLOGICAL THERAPY; CELL ASSAY; COCULTURE; CYTOKINE RELEASE; CYTOKINE RELEASE SYNDROME; CYTOKINE STORM; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PERIPHERAL BLOOD STEM CELL; PERSONALIZED MEDICINE; PRIORITY JOURNAL; BIOASSAY; CELL PROLIFERATION; CHEMISTRY; CULTURE MEDIUM; CYTOLOGY; DRUG EFFECTS; ENZYME LINKED IMMUNOSORBENT ASSAY; METABOLISM; MONONUCLEAR CELL; PHARMACOLOGY; PROCEDURES; REPRODUCIBILITY; SERUM; UMBILICAL VEIN ENDOTHELIAL CELL;

ANTIBODIES, MONOCLONAL; ANTIBODIES, MONOCLONAL, HUMANIZED; BEVACIZUMAB; BIOLOGICAL ASSAY; BIOLOGICAL PRODUCTS; CELL PROLIFERATION; COCULTURE TECHNIQUES; CULTURE MEDIA; CYTOKINES; ENDOTHELIAL CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INTERLEUKIN-2; INTERLEUKIN-6; INTERLEUKIN-8; LEUKOCYTES, MONONUCLEAR; REPRODUCIBILITY OF RESULTS; SERUM; TRASTUZUMAB; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84933564550     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.14-268144     Document Type: Article

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