A novel method to analyze hepatotoxic components in Polygonum multiflorum using ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry

Journal of Hazardous Materials

Volumn 299, Issue , 2015, Pages 249-259

  Lin, Longfei ^a   Lin, Hongmei ^a   Zhang, Miao ^a   Ni, Boran ^a   Yin, Xingbin ^a   Qu, Changhai ^a   Ni, Jian ^a  

^a BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Hepatotoxicity; Polygonum multiflorum; Polygonum multiflorum Praeparata; Toxicity; UPLC Q TOF MS

Indexed keywords

AMINO ACIDS; ASSAYS; CHROMATOGRAPHY; ENZYMES; ETHANOL; KETONES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MEDICINE; PHYSIOLOGY; PLANTS (BOTANY); RESEARCH AIRCRAFT; TOXICITY;

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; HEPATOTOXICITY; LACTATE DEHYDROGENASE; POLYGONUM MULTIFLORUM; TRADITIONAL CHINESE MEDICINE; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY QUADRUPOLE TIME OF FLIGHT MASS SPECTROMETRIES; UPLC-Q-TOF/MS;

EXTRACTION;

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CATECHIN; CIS 2,3,5,4' TETRAHYDROXYSTILBENE 2 O GLC; CIS RHAPONITIN; CITRIC ACID; EMODIN; EMODIN 0 (MALONYL) HEX; EMODIN 0 HEX SULPHATE; EMODIN O (ACETYL) HEX; EMODIN O GLC; EPICATECHIN; GALLIC ACID; GLUCOSYL GALLATE; GULONIC ACID; HEPTADECANOIC ACID ESTER; LACTATE DEHYDROGENASE; MALIC ACID; MONO O GALLOYLPROCYANIDIN; N ACRYLOYL GLYCINE; N TRANS FERULOYL TYRAMINE; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; POLYGONUM MULTIFLORUM EXTRACT; TETRAHYDROXYSTILBENE O (ACETYL) HEX; TETRAHYDROXYSTILBENE O DI HEX; TETRAHYDROXYSTILBENE O HEX; TETRAHYDROXYSTILBENEO (GALLOYL) HEX; TORACHRYSONE 8 O GLC; TREHALULOSE; UNCLASSIFIED DRUG;

BIOASSAY; ENZYME ACTIVITY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MEDICINE; PAH; SECRETION; SOFTWARE; TOXIC SUBSTANCE; TOXICITY; TOXICITY TEST;

ARTICLE; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME RELEASE; FALLOPIA MULTIFLORA; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL; LIVER FUNCTION; LIVER TOXICITY; QUADRUPOLE MASS SPECTROMETRY; TIME OF FLIGHT MASS SPECTROMETRY; TOXICITY TESTING; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; CELL LINE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; LIQUID CHROMATOGRAPHY; LIVER; MASS SPECTROMETRY; PROCEDURES;

POLYGONUM MULTIFLORUM;

CELL LINE; CHROMATOGRAPHY, LIQUID; FALLOPIA MULTIFLORA; HUMANS; LIVER; MASS SPECTROMETRY; PLANT EXTRACTS;

EID: 84933532024     PISSN: 03043894     EISSN: 18733336     Source Type: Journal    
DOI: 10.1016/j.jhazmat.2015.06.014     Document Type: Article

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