Pseudopterosin biosynthesis: Aromatization of the diterpene cyclase product, elisabethatriene

Marine Drugs

Volumn 1, Issue 1, 2003, Pages 54-65

  Kohl, Amber C ^a   Kerr, Russell G ^a  

^a FLORIDA ATLANTIC UNIVERSITY   (United States)

Author keywords

Biosynthesis; Diterpene; Elisabethatriene; Pseudopterogorgia elisabethae; Pseudopterosin

Indexed keywords

EID: 25144445795     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md101054     Document Type: Article

References (12)

1. Look, S.; Fenical, W.; Matsumoto, G.; Clardy, J. The pseudopterosins: a new class of anti-inflammatory and analgesic diterpene pentosides from the marine sea whip Pseudopterogorgia elisabethae (Octocorallia). J. Org. Chem. 1986, 51, 5140-5145.
2. Roussis, V.; Wu Z.; Fenical, W. New antiinflammatory pseudopterosins from the marine octocoral Pseudopterogorgia elisabethae. J. Org. Chem. 1990, 55, 4916-4922.
3. Ata, A.; Kerr, R.; Moya, C; Jacobs, R. Identification of anti-inflammatory diterpenes from the marine gorgonian Pseudopterogorgia elisabethae. Tetrahedron 2003, 59, 4215-4222.
4. Look, S.; Fenical, W. The seco-pseudopterosins, new anti-inflammatory diterpene-glycosides from a Caribbean gorgonian octocoral of the genus Pseudopterogorgia. Tetrahedron 1987, 43, 3363-3370.
5. Ettouati, W; Jacobs, R. Effect of pseudopterosin A on cell division, cell cycle progression, DNA, and protein synthesis in cultured sea urchin embryos. Mol. Pharmacol. 1987, 31, 500-505.
6. Look, S.; Fenical, W.; Jacobs, R.; Clardy, J. The pseudopterosins: anti-inflammatory and analgesic natural products from the sea whip Pseudopterogorgia elisabethae. Proc. Natl. Acad. Sci. USA 1986, 83, 6238-6240.
7. Mayer, A.; Jacobson, P.; Fenical, W.; Jacobs R. Pharmacological characterization of the pseudopterosins: novel anti-inflammatory natural products isolated from the Caribbean soft coral, Pseudopterogorgia elisabethae. Life Sci. 1998, 62, 401-407.
8. Coleman, A.; Kerr, R. Radioactivity-guided isolation and characterization of the bicyclic pseudopterosin diterpene cyclase product from Pseudopterogorgia elisabethae. Tetrahedron 2000, 56, 9569-9574.
9. Rodríguez, A.; Ramírez, C. Serrulatane diterpenes with antimycobacterial activity isolated from the west Indian sea whip Pseudopterogorgia elisabethae. J. Nat. Prod. 2001, 64, 100-102.
10. Ata, A. and Kerr, R. Unpublished results.
11. Lee, H.; Harvey, R. Synthesis of cyclopentanobenz[a]anthracene compounds related to carcinogenic benz[a]anthracene and cholanthrene hydrocarbons. J. Org. Chem. 1990, 55, 3787-3791.
12. Tsigdinos, G.; Hallada, C. Molybdovanadophosphoric acids and their salts. I. Investigation of methods of preparation and characterization. Inorg. Chem. 1968, 7, 437-441.