Evaluation of analgesic, anti-inflammatory, anti-depressant and anti-coagulant properties of Lactuca sativa (CV. Grand Rapids) plant tissues and cell suspension in rats

BMC Complementary and Alternative Medicine

Volumn 15, Issue 1, 2015, Pages

  Ismail, Hammad ^a   Mirza, Bushra ^a  

^a QUAID I AZAM UNIVERSITY   (Pakistan)

Author keywords

Analgesic; Anti Inflammatory; Anticoagulant; Antidepressant; Cell suspension; Lactuca sativa

Indexed keywords

ACETYLSALICYLIC ACID; ANALGESIC AGENT; ANTICOAGULANT AGENT; ANTIDEPRESSANT AGENT; ANTIINFLAMMATORY AGENT; LACTUCA SATIVA EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICOAGULATION; ANTIDEPRESSANT ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BEHAVIOR CHANGE; BLOOD CLOTTING TEST; BLOOD CLOTTING TIME; CELL SUSPENSION; CONTROLLED STUDY; DEPRESSION; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG RESPONSE; FORCED SWIM TEST; HOT PLATE TEST; LETTUCE; NONHUMAN; PAIN; PAW EDEMA; PLANT LEAF; PLANT SEED; PLANT TISSUE; RAT; ANALGESIA; ANIMAL; BLOOD CLOTTING; CHEMISTRY; DRUG EFFECTS; PROCEDURES;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTICOAGULANTS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; BLOOD COAGULATION; LETTUCE; PAIN MANAGEMENT; PLANT EXTRACTS; RATS;

EID: 84933503438     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/s12906-015-0742-0     Document Type: Article

References (27)

1. Nicolle C, Cardinault N, Gueux E, Jaffrelo L, Rock E, Mazur A, et al. Health effect of vegetable-based diet: lettuce consumption improves cholesterol metabolism and antioxidant status in the rat. Clin Nutr. 2004;23:605-14.
2. Araruna K, Carlos B. Anti-inflammatory activities of triterpene lactones from Lactuca sativa. Phytopharmacology. 2010;1:1-6.
3. Hefnawy TM, Ramadan MF. Protective effects of Lactuca sativa ethanolic extract on carbon tetrachloride induced oxidative damage in rats. Asian Pacific J Trop Dis. 2013;3:277-85.
4. Sayyah M, Hadidi N, Kamalinejad M. Analgesic and anti-inflammatory activity of Lactuca sativa seed extract in rats. J Ethnopharmacol. 2004;92:325-9.
5. Teng WL, Liu YJ, Soong TS. Rapid regeneration of lettuce from suspension culture. Hort Sci. 1992;27:1030-2.
6. Allen JW, Yaksh TL. Assessment of acute thermal nociception in laboratory animals. Methods Mol Med. 2004;99:11-23.
7. Ravi V, Saleem T, Patel S, Raamamurthy J, Gauthaman K. Anti-inflammatory effect of methanolic extract of Solanum nigrum Linn berries. Int J Appl Res Nat Prod. 2009;2:33-6.
8. Vane JR, Botting RM. Anti-inflammatory drugs and their mechanism of action. Inflamm Res. 1998;47:S78-87.
9. Porsolt RD, Pichon MLE, Jalfre M. Depression: a new animal model sensitive to antidepressant treatments. Nature. 1977;266:730-2.
10. Cryan JF, Valentino RJ, Lucki I. Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test. Neurosci Biobehav Rev. 2005;29:547-69.
11. Hirsh J, Donnell MO, Weitz JI. Review in translational hematology; New anticoagulants. Blood. 2005;105:453-63.
12. Okwu DE. Citrus fruits: A rich source of phytochemicals and their roles in human health. Int J Chem Sci. 2008;6:451-71.
13. Mohebodini M, Javaran MJ, Mahboudi F, Alizadeh H. Effects of genotype, explant age and growth regulators on callus induction and direct shoot regeneration of Lettuce (Lactuca sativa L.). Aust J Crop Sci. 2011;5:92-5.
14. Eddy NB, Leimbach D. Synthetic analgesic. II. dithienylbutenyl- and dithienylbutylamines. J Pharmacol Exp Ther. 1952;107:385-93.
15. Winter CA, Risley EA, Nuss GW. Carrageenin-induced edema in hind paw of the rat as an assay for antiinflammatory drugs. Exp Biol Med. 1962;111:544-7.
16. Slattery DA, Cryan JF. Using the rat forced swim test to assess antidepressant-like activity in rodents. Nat Protoc. 2012;7:1009-14.
17. Prasad SS, Kumar S, Patel K, Dumater C, Vajpeyee SK. To investigate the action of ginger-juice zingiber (zingiberaceae) on blood coagulation process. Int J Pharma Sci Res. 2012;3:407-15.
18. Sharma N, Aggarwal SG, Kala RP, Kumar A. Analgesic activity of Swertia chirayita. World J Pharm Sci. 2013;2:3667-75.
19. Hugar MH, Hosamani KM, Ahmed L. Phytochemical and pharmacological studies of ethanol extract of Dalbergia sissoo seeds : An approach for the in-vivo analgesic and antipyretic activities. Int J Pharma Bio Sci. 2010;1:272-80.
20. Khan I, Nisar M, Ebad F, Nadeem S, Saeed M, Khan H, et al. Anti-inflammatory activities of Sieboldogenin from Smilax china Linn.: experimental and computational studies. J Ethnopharmacol. 2009;121:175-7.
21. Suh N, Honda T, Finlay HJ, Barchowsky A, Williams C, Benoit NE, et al. Novel triterpenoids suppress inducible nitric oxide synthase (inos) and inducible cyclooxygenase (cox-2) in mouse macrophages. Cancer Res. 1998;58:717-23.
22. Glory JI, Elizabeth AA, Muniappan M, Muthiah M. Antidepressant activity of Foeniculum vulgare in forced swimming and tail suspension test. Res J Pharm Biol Chem Sci. 2014;5:448-54.
23. Detke MJ, Rickels M, Lucki I. Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants. Psychopharmacology (Berl). 1995;121:66-72.
24. Kirby LG, Lucki I. Interaction between the forced swimming test and fluoxetine treatment on extracellular 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in the rat. J Pharmacol Exp Ther. 1997;282:967-76.
25. Pietta PG. Flavonoids as antioxidants. J Nat Prod. 2000;63:1035-42.
26. Ridker PM. Cardiology Patient Page. C-reactive protein: a simple test to help predict risk of heart attack and stroke. Circulation. 2003;108:e81-5.
27. Ashour TH. Preventative effects of caffeic Acid phenyl ester on cadmium intoxication induced hematological and blood coagulation disturbances and hepatorenal damage in rats. ISRN Hematol. 2014;2014:764754.